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Q2 Pharm ABX, Vomit > Sulfonamides (Lec 17) > Flashcards

Sulfonamides (Lec 17) Flashcards

1
Q

Sulfa drugs are derivatives of what?

A

benzene:

substitution at amino group

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2
Q

Sulfa drug mechanism of action?

A

all have same bacteriostatic action:
bind to free para amino group,
blocks PABA from binding,
stops formation of folic acid

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3
Q

Trimethoprim drug mechanism?

A

stop reduction of dihydrofolate to tetrahydrofolate

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4
Q

Co-trimoxazole and Bactrim are?

A

sulfamethoxazole + trimethoprim

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5
Q

Sulfa drug active against?

A

G+ and G- (bacteriostatic)

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6
Q

DOC for UTI?

A

Co-trimoxazole

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7
Q

Sulfa administration?

A

oral

IV

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8
Q

Sulfa absorption?

A

very high in urine

can cross placenta, blood-brain and mammary barriers

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9
Q

Sulfa side-effects?

A

Allergy
Steven-Johnson synd
Kernicterus (bind bilirubin)
All systems, esp liver/kidneys

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10
Q

Lipopeptide Abx are?

A

cyclic lipoproetins

Daptomycin

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11
Q

Daptomycin mechanism?

A

Binds membrane ->
rapid depolarizes memb potential ->
inhibits everything (cidal)

Does not penetrate bacteria cytoplasm

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12
Q

Daptomycin active against?

A

G+ aerob and anaerobe

including MRSA, MSSA

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13
Q

Daptomycin route of administration?

A

IV

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14
Q

Daptomycin suitable empiric tx for?

A

serious G+ infections

alternate to vancomycin

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15
Q

Mupirocin (Bactroban) made from?

A

pseudomonas fluorescens

structurally different from ALL other abx

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16
Q

Mupirocin mechanism?

A

inhibit protein and RNA synth

static or cidal depending on [drug]

17
Q

Mupirocin active against?

A

G+ and G-

little chance of cross-resistance to other abx cuz mechanism unique

18
Q

Mupirocin DOC for what infection?

A

impetigo:
s areus, strep pyognes

Also treats MRSA in nasal passages

19
Q

Polypeptide Abx: Polymyxin B

mechanism?

A

binds memb phospholipid A ->
↑ permeability ->
loses metabolites

20
Q

Polypeptide Abx: Polymyxin B

active against?

A

G- bacilli

EXCEPT proteus and neisseria

21
Q

Polypeptide Abx: Polymyxin B not effective against G+, why?

A

lacks endotoxins

22
Q

Polypeptide Abx: Polymyxin B administered?

A

topically

23
Q

Polypeptide Abx: Polymyxin B

side-effects?

A

nephrotoxicity if taken orally

Q2 Pharm ABX, Vomit (13 decks)

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