Antihelminitcs: worms (Lec 19)

Question 1

Nematodes characteristics?

Answer 1

1) non-segmented
2) ingest thru contaminated food
3) live in blood, tissues

Question 2

Types of Nematodes? (4)

Answer 2

1) roundworm
2) pinworm
3) hookworm (live in lungs)
4) trichinosis (raw pork)

Question 3

Cestodes characteristics?

Answer 3

Tapeworms

1) segmented, flat w/ suckers
2) eggs passed in feces
3) live in eye, liver, mm, brain and intestines

Question 4

Trematodes characteristics?

Answer 4

Flukes

1) non-seg, flat w/ 2 suckers
2) worms thru food or penetrate skin
3) live in intestine, lung. liver

Question 5

Lung fluke sxs?

Answer 5

cough
hemoptysis
chest pain

Question 6

Liver fluke sxs?

Answer 6

bile duct blockage
liver enlargement
RUQ pain

Question 7

Shistosomes characteristics?

Answer 7

Blood Flukes

1) penetrate skin thru dirty water
2) to blood and liver
3) lay eggs and spread thru body

Question 8

Antihelminitics mechanism? (4)

Answer 8

interferes w/

1) energy metabolism
2) neuromuscular coord
3) microtubular fxn
4) cell permeability

Question 9

Pyrantel Pamoate mechanism?

Answer 9

neuromuscular blocker

Question 10

Pyrantel Pamoate active against?

Answer 10

Nematodes

Question 11

Pyrantel Pamoate administration?

Answer 11

oral

OTC

Question 12

Ivermectin mechanism?

Answer 12

paralysis

Question 13

Ivermectin active against?

Answer 13

Nematodes, threadworm, cutaneous larva

Question 14

Ivermectin DOC for?

Answer 14

filaria (type of nematode)

Question 15

Prazipuantel active against?

Answer 15

Cestodes and Trematodes

DOC for Shistosomes (blood flukes)

Question 16

Prazipuantel mechanism?

Answer 16

↑ worm’s permeability to Ca2+

Question 17

Biothinol mechanism?

Answer 17

uncouples oxidative phosphorylation

Question 18

Biothinol active against?

Answer 18

Trematodes

DOC for sheep liver fluke