Sugar Metabolism

Question 1

How is glycolysis regulated? By what?

Answer 1

High NADH signals
This signals high energy levels
–> low [NAD+]
inhibits step 6- G3P–>1,3 BPG

Question 2

Important Intermediates of Glycolysis

Answer 2

DHAP
produces Glycerol Phosphate (in adipose and liver)
needed for synthesis of TAG’s

1,3 BPG
produces 2,3 BPG
important regulator of O2 affinity in Hb
(forms cross links- converts t to T form)

Question 3

State reasons for increased lactate production

Answer 3

Increased production- (strenuous exercise, shock, CHD, alcohol metabolism produces NADH)

Decreased utilisation- (liver disease, thiamine deficiency)