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Biochemistry > Substrate Binding > Flashcards

Substrate Binding Flashcards

1
Q

What are the five metabolic reactions?

A
  1. Nucleophillic Substitution: swap functional group
  2. Nucleophilic addition: add function group
  3. Carbonyl Condensation: Change number of carbons
  4. Elimination: change bond order
  5. Oxidation-Reduction: move electrons
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2
Q

Oxidoreductase activated carriers and co enzymes and action of each.

A
  • NADH: carries a single electron
  • NADPH: carries single electron
  • FADH2: carry two electrons
  • FMNH2: carry two electrons
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3
Q

Building blocks of NADP?

A

Vitamin B3 and Adenine

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4
Q

Building blocks of FMNH and FADH?

A

Vitamin B2 and Adenine

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5
Q

What are the activated carriers for Transferases and what do they do?

A
  • ATP : move phosphate
  • Pyridoxal phosphate: move phosphate
  • SAM: move methyl
  • Tetrrahydrofolate: move methyl
  • 5’-deoxyadenosylcobalamin: move methyl
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6
Q

What are the building blocks of SAM?

A

Methionine and adenine

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7
Q

Building blocks of Tetrahydrofolate?

A

B9 and glutamate

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8
Q

Building blocks for 5’deoxyadenosylcobalamin?

A

B12 in a metabolically active state

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9
Q

What do hydrolases do?

A

Break a chemical bond with water

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10
Q

What do isomerases do?

A

Rearrange th eorder of atoms

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11
Q

What does a lyase do?

A

Break bonds without water

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12
Q

What does a ligase do and what are its activated carriers?

A

Make bonds using ATP

  • TPP: moving aldehydes
  • CoASH: moving acyl group
  • Lipoamine: moving acyl group
  • Biotin:moving a CO2 group
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13
Q

What makes up TPP?

A

B1 and 2 phosphates

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14
Q

What are the building blocks to CoASH ?

A

B5 and adenine

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15
Q

Building blocks to lipoamide?

A

Fatty acid and lysine

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16
Q

Building blocks to biotin?

A

Biotin is B7 and add a lysine

17
Q

Allosteric binding?

A

Doesn’t occur at the active site but follows same actions as an active site. Involves a second substrate that can activate or inhibit.

18
Q

What is Kd?

A
  • Equal to concentration of ligand where half the sites are available
19
Q

If Fractional Saturation (Y) is 1 what does that mean?

A

receptor is saturated

20
Q

If Fractional Saturation (Y) is 0.5 what does that mean?

A

receptor is half saturated

21
Q

What does it mean if Nh =1?

A

No cooperativity

22
Q

What does it mean if Nh>1?

A

Positive cooperatitivy, affinity increases

23
Q

What does it mean if Nh is greater than 0 but less than 1?

A

Negative cooperativity

Biochemistry (14 decks)

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