Enzymes Catalysis Flashcards
1
Q
What are the four catalytic strategies?
A
Covalent Catalysis
Acid base catalysis
Approximation
Electrostatic catalysis
2
Q
Covalent catalysis?
A
Enzyme covalently binds the transition state and electrons are transferred
3
Q
Acid base catalysis?
A
Partial proton transfer to the substrate
Acids donate H and bases recieve
4
Q
Approximation?
A
Proper spatial orientation and close proximity of molecules to allow protons or electrons to be exchanged. Entropy reduction.
5
Q
Electrostatic catalysis?
A
stabilize unfavorable charges on transition state by polarizable side chains in the enzyme or metal ions
6
Q
Why do we need proteases?
A
Recycling Regulation and Defense
