Substance Abuse Flashcards
Difference between precipitated withdrawl and conditioned withdrawl
Precip – Pharmacologicaly-induced onset
Conditioned – Withdrawl brought on by environmental cues
Drugs involved in alcohol metabolism
Fomepizole – blocks alc. dehydrogenase (for methanol, ethylene glycol poisoning)
Disulfram – Ald. dehydrogenase (encourages abstin. in motivated quitters)
Important alcohol drug interactions
Synergy with CNS depresants (opoids, ADs, sedatives)
Inhibit metabolism (phenothiazines, TCAs)
Disulfram
Acetaminophen
Contraindications for Alcohol
None.
Just kidding – Liver disease, Peptic Ulcer, Epilepsy
Treatments for ethanol absitinence syndrome
Maintain K, Mg, Ph
Thiamine (for WK)
Sedative hypnotics (Benzo)
Antidepressants
Importance of Naltrexone
mu, kappa opioid antagonist
Inhibits the DA release from alcohol use
Importance of Acamprosate
GABA activator, NMDA antag.
Name two indogenous cannabinoids
2-AG
Anandamide
Active agent in Marijuana? the synthetic version?
delta9-tetrahydrocannabinol
Dronabinol
When to use dronabinol
Chemo nausea/vom
AIDS weight control
What is nabilone?
Nabilone - THC analog for chronic pain
Rimonabant - CB1 inv. aonist appe
5HT based Hallucinogens
LSD (5ht2a PA)
MDMA (Ecstasy) – (5HT, NE, DA release)
Mescaline - 5ht2a PA
Psilocybin (mushrooms) – NMDA, nACHR antag
Glu based Hallucinogens
Phencyclidine (PCP)
Ketamine
How do opioids increase dopamine transmission
MOR activation inhibits VGCC, reducing GABA and activating GIRK
What is morphine? Its use?
MOR Agonist
Analgesia
