Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm Penultimate Exam > Migraine > Flashcards

Migraine Flashcards

1
Q

Cortical Spreading Depression in a migraine elevates levels of extracellular…

A

K, H, NO, AA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

5HT receptor roles in the trigeminovascular system

A

1B – Vasoconstriction
1D – Inhibition of NT release
1F – inhibit release of nociceptive molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Drugs/Types used to abort migraines

A

Acetaminophen
Aspirin/NSAIDS
Serotonin Agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Drugs/Types used to prevent migraines

A

beta blockers
tricyclic antidepressants
anticonvulsants
botox

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Important Analgesic combinations used in Migraine treatment

A

Excedrin Migraine - Acet., Asp., Caffeine
Migralam - Acet., Caff., Isometheptene
Midran - Acet., Isometheptene, Dichlorophenazone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Migraine treatments to avoid whenever possible because they include opoids

A

Fiorinal, Fiorice
Butorphanol
Hydromorphone, Oxycodone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Antiemetics used as adjunct treatment in Migraine

A

Metoclopramide (inc. gastric emptying –> increase abs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Symptoms of Ergot poisoning

A

Nausea/Diarrhea/Vomiting
Gangrenous Limbs
Psychoses
Spontaneous Abortions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Ergot alkaloids used to abort migraine include…

A

Ergotamine

Dihydroergotamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Hoe do ergot alkaloids work

A

They are 5HT 2a/1b/1d/1f agonists + alpha 1 agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Absorption data on ergot alkaloids

A

Ergotamine – Sublingual tablets

DHE – IM Injection/Nasal Spray

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Important ergot alkaloid drug interactions to be aware of

A

HIV protease inhibitos, macrolides raise them

DHE decreases nitrate efficacy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Sumatriptan important details

A

Synthetic 5HT 1b/D/F agonist

Faster onset than DHEm but shorter half life, so it can allow for headache recurrence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Naratriptan important details

A

Slower onset, longer duration of action, lower recurrance than sumatriptan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Frovatriptan important details

A

Tricyclic Structure, orally active

2-4 hrs to onset, but 26 hour half life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Triptan contraindications

A
  • Precipitate angina – not for CAD patients
  • Sumatrip. – Not w/ MAOIs
  • Naratriptan – Not w/ Severe hepatic/renal impairment, PVD
17
Q

Zolmitriptan contraindication

A

WPW Syndrome

18
Q

Rizatriptan contraindication

A

not for PKU patients

19
Q

What is status migrainosus? first line treatmnet?

A

Headache over 72 hours w/ or w/out treatment

Treat w/ Triptans (subQ suma)

20
Q

First line agents to prevent migraines

A

beta blockers (propanolol, timilol)
Topiramate
Tricyclics
Valproic Acid

21
Q

How does botox prevent migraines?

A

Toxin light chains cleave SNAP25, inhibiting NT release

Axonal transport from periphery to meninges

22
Q

When is it appropriate to use Botox to treat migraine

A

Chronic migraine (15/month for 3 months)
Use other drugs at least 10 days/month
Headache worsening

Pharm Penultimate Exam (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions