Medical Neuropharmacology Flashcards
1
Q
Dopamine secretion in concentrated where in brain
A
Ventral tegmental area
substantia nigra pars compacta
2
Q
NE neurons can be found…
A
inthe nucleus ceruleus
3
Q
GABA is modifified in diseases such as…
A
Epilepsy
Spasticity
Addiction/Alcoholism
4
Q
Glutamate is being studied in diseases such as..
A
Epilepsy
Schizophrenia
5
Q
IMportant details about Saturation Assay
A
Direct assessment of affinity of drug for receptor (Kd)
Requires both the drug and the receptor
6
Q
Bmax =
A
Total number of receptors in a preparation
7
Q
Important details abotu Competition assays
A
known labeled + unlabeled test drug
comparison of affinity to measured drug
rapid + cheaper than saturation assay
8
Q
Ki=
A
in competition assay, measure of concentration of drug where 50% radioligand is displaced
