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Abrupt RUQ/epigastric pain. Resolves slowly lasting 30-hours. Nausea precipitated by fatty foods or large meals
Dx? TX?
Cholelithiasis
Dx- US Tx- Elective cholecystectomy
Gallstones in the common bile duct assoc. w duct dilation.
Dx: Tx?
Choledocholithiasis
Dx- ERCP TX-ERCP stone extraction
Obstruction of the Biliary tract –> to biliary tract infection. MC 2T E. Coli or Klebsiella. Charcot’s/Reynold
Labs: Increased ALP, GGT, and Bilirubin
Dx- Tx-?
Acute Cholangitis
Dx- CT (GS-ERCP) Tx- ABX + ERCP
Inflammation/infection 2T gall bladder obstruction @ cystic duct. E.coli/Klebsiella MC.
(+) Murphy’s sign RUQ pain, precipitated by fatty/large meals. DX- Initial and GS Tx-
Cholecystitis
Dx- Initial=US “GS=HIDA scan” Tx- NPO, IV, ABX,Sx
SLE specific Diagnosis labs?
- (+) Anti double stranded DNA
- (+) Anti-smith
Scleroderma specific Lab Dx?
(+) Anti-centromere AB
+) Anti-SCL 70 (Diffuse disease
Rheumatoid Arthritis specific and initial lab Dx?
Anti-Cyclic citrullinated peptide ABs (specific)
RF (Initial test)
Polymyositis / Dermatomyositis specific lab dx?
(+) Anti-Jo 1 Ab
(+)Anti-SRP Ab (PM)
(+) Anti-Mi2 Ab (DM)
Sjogren’s Syndrome specific lab Dx?
ANA- Anti SS-A (RO)
Anti SS-B (La)
Schirmmer test
< 16 yo: Daily Arthritis, diurnal high fever, salmon color migratory rash?
Juvenile Idiopathic Arthritis (Still’s Disease)
< or > 5 joint involvement joint pain with iridocyclitis (Uveitis)
Juvenile Idiopathic Arthritis
Pauci-Articular (< 5)
Poly-Articular (>5)
Asymmetric Arthritis: dactylitis (Sausage digits), sacroiliitis, uveitis, pitting of nails (Pencil in cup), +
HLAB27
Psoriatric Arthritis
Sacroiliac joint inflammation with progressive stiffness: 15-30 yo: chronic LBP: Increased ESR/HLAB27
Ankylosing Spondylitis (Bamboo Spine)
Autoimmune response inflammation caused by “chlamydia”, gonorrhea, salmonella, campy, shigella
Arthritis, conjunctivitis, and urethritis.
Reactive Arthritis ( Reiter’s Syndrome)
spinal cord controls Voluntary motor activity: Terminates at anterior horn cell: ascends/descends same side
Corticospinal Tract
senses vibration, position and light touch:
Ascends same side, decussates @ medulla
Dorsal Columns tract
Senses pain and temperature and ascends at opposite sides crosses immediately
Spinothalamic Tract
Motor efferent pathway (Away) of spinal cord
Anterior (Ventral Root) (Feeling, fast, front)
Sensory Afferent pathway (Towards) pf spinal cord
Posterior (Dorsal Root)
Progressive motor degeneration 2T UMN/LMN necrosis: dysphagia, eventually respiratory: fatal 3-5 years
sensation, urinary sphincter, voluntary eye movement spared Tx:
Amyotrophic Lateral Sclerosis (ALS)
Tx: Riluzole
Autosomal dominant nuero-degenerative disease: Chromosome 4 mutation/Abnormal CAG transcription:
behavioral (irritability), chorea, and dementia (<50): Tx? Caudate nucleus (Putamen) Atrophy: Fatal 15-20 years
Huntington Disease
Tx: Chorea (Tetrabenzine Antidopaminorgics)
- Resting Tremor (MC lessened with voluntary m.)
- Bradykinesia (slow voluntary movement)
- Rigidity
- Flat Facis (Myerson’s nose tap=blink)
- Instability w posture
Parkinson’s disease clinical manifestations X5
Parkinson’s Disease Tx?
- Levodopa/Carbidopa- converted to dopamine (M.E Tx)
- Bromocriptine (D. Agonists)
- Benztropine (Anticholinergic)
Demyelinating polyradiculopathy of the peripheral nerves. Ascending symmetric weakness/paresthesia
Assoc. w Campylobacter. Tx:
Guillian Barre Syndrome
Autoimmune Inflammatory demyelinating degeneration of white matter. sensory pain/fatigue, cramping,
suspect w young and trigeminal neuralgia, optic neuritis episodic exacerbations; :Tx
Multiple Sclerosis
Tx: IVCS, plasmapheresis, Amantadine (Fatigue) Glatiramer acetate (Reduces relapse severity)
Autoimmune peripheral nerve disorder against Ach Receptors. Thymic hyperplasia/thymoma
General muscle weakness (Ocular, Resp., Bulbar): relieved w rest Tx:
Myasthenia Gravis
Tx: Pyridostigmine or Neostigmine 1st line
Plasmapheresis or IV Ig
Restless leg syndrome treatment?
- Pramipexole
- Ropinirole (Both domapine Agonists)
CSF: High protein (>400) with a normal WBC (Albumin cytological dissociation)
Electrophysiologic decreased motor nerve conduction: Diagnosis studies for?
Guillain Barre Syndrome
MRI with Gadollinium (TOC) confirms disorder showing white matter plaque hyper densities (Periventricular).
Multiple Sclerosis
Blood test shows Acetylcholine receptor Antibodies (+) Muscle specific Tyrosine Kinase (Musk)
Myasthenia Gravis
LP CSF shows increase IgG oligoclonal bands “Pleocytosis”
Multiple Sclerosis
Myasthenia gravis Test that includes a rapid response to short acting IV_______?
Edrophonium
Constant daily Headache: not worse with activity: BL tight-band/vise-like no phono/photo phobia
Tx: Prophylaxis and abortive
Tension Headache
Tx: A-NSAI/APAP Amitriptyline P- BBs
Headache 4-72 hour in duration: pulsatile, lateralized, throbbing. NV, Phono/Photo phobia, worse w activity
Tx: Abortive and Prophylaxis
Migraine Headache
Tx: A- Triptans/Ergotamines (5HT-1) vasoconstrictions
Metoclopramide, Promethazine, Prochlorperazine. (DBs)
P- BBs/CCBs/TCAs
UL Headache: Temporal, periorbital, lancinating, < 2hoursseveral times a day/6-8 weeks. worse night/Etoh
Horner’s syndrome, UL congestion/lacrimation:
Tx: A- P-
Cluster Headache
Tx: A- 100% O2: Triptan/Ergotamines (Sumatriptan nasal)
P- Verapamil
Motor and sensory deficits in upper extremities in a “shawl distribution.
Central cord syndrome
Ipsilateral motor vibratory and proprioception deficits and contralateral pain and temperature deficits
Brown Sequard syndrome
Loss of temperature and pain in lower extremities. TEE-Pee
Anterior Cord Syndrome
Damage Associated with voluminous meaningless impaired comprehension (Word Soup)
Wernicke’s Aphasia
Damage Associated with difficulty remembering words or speaking with relatively preserved
Broca’s Aphasia
MC type of stroke and what vessel?
Ischemic (Middle cerebral Artery)
MC Arterial bleed: Between skull and Dura: involves medial meningeal artery: Lens shape (Convex)
Epidural Hematoma (Hemorrhage)
MC Venous bleed: Between dura and arachnoid: involves tearing of bridging veins: Blunt Trauma “elderly”
Slow onset and crescent shape: “Midline shift”
Subdural Hematoma (Hemorrhage)
Bleed between arachnoid and pia: MC Berry Aneurysm rupture: Sudden thunderclap worse HA of life:
Subarachnoid Hemorrhage
Intraparenchymal hemorrhage: HTN, trauma or arteriovenous malformation: LP–> herniation
Intracerebral Hemorrhage
- Proteinuria
- Hypoalbuminemia
- Hyperlipidemia
Nephrotic syndrome manifestations
- Hematuria (RBC casts)
- HTN
- Edema /Azotemia (High nitrogen in blood
Acute Glomerulonephritis (Nephritic Syndrome)
Nephrotic syndrome includes what 3 etiologies?
Minimal Change
Focal Segmental Glomerulosclerosis
membranous nephropathy
MC Nephrotic syndrome etiology occurring in children: Effacement of podocytes: Tx is Prednisone
Minimal change Disease
Nephrotic syndrome etiology Involves AA, HTN and fibrosis of glomerulus: “Not Steroid responsive”
Focal Segmental Glomerulosclerosis
Nephrotic syndrome etiology Involves thickening of the glomerular basement membrane: 2T immune complex depositions
Membranous Nephropathy
Nephritic Syndrome (AGN) includes what etiologies?
- IgA Nephropathy (Berger’s Disease)
- Post infectious
- Rapidly Progressive GN
- Good Pasture’s
Nephritic Syndrome (AGN) MC after GABHS or Impetigo: Facial Edema: Post-Strep: coca cola urine
Post Infectious GN
Nephritic Syndrome (AGN): Linear IgG depositis, hemoptysis and kidney failure (Hematuria)
Good Pasture’s
Nephritic Syndrome (AGN) progresses to ESRD in weeks due to fibrin and protein deposition:
Crescent formation biopsy Tx:
Rapid Progression GN
CS and Cyclophosphamide
MC Nephritic Syndrome (AGN) in adults WW: post URI or GI infection; IgA mesangial deposits: Tx: ACE/ CS
IgA Nephropathy (Berger’s Disease)
Acute Kidney Injury Types
Prerenal (MC). Intrinsic, and post renal.
MCC of prerenal AKI is _______: which leads to_______? BUN:Cr is?
Hypovolemia (NSAID/IV contrast): ATN
B:Cr 20:1
Intrinsic types of AKI?
Acute Tubular necrosis (ATN MC type)
Acute tubulointerstitial nephritis (AIN)
Intrinsic AKI caused by hypo/ tension-volemia or aminoglycosides: UA= Muddy Brown casts/Epithelial cell
ATN
AIN is caused by a ________–> to ________ casts?
Hypersensitivity (PCN, NSAID Sulfa: WBC Casts
RBC casts are pathognomonic for ?
Acute Glomerulonephritis
FeNa >2 you think what AKI?
ATN
Low FeNa< 2 you think what type of AKI?
Prerenal
Incontinence marked by overactive bladder Detrusor muscle?
Tx:Urge incontinence
Urge incontinence
Tx: Oxybutynin or Tolterodine (Anticholinergics)
TCA-Mirabregon
Incontinence marked by increased abd. pressure, ;laxity of pelvic floor muscle: laughing, sneezing, coughing
Tx:
Stress Incontinence
Tx: Midodrine
Incontinence marked by urinary retention (incomplete emptying). underactive detrusor muscle:
Dx:
Overflow Incontinence
Dx: Post void residual .200 ml Tx: Tamsulosin (A-1 b)
Dx: PSA < 4
Tx: 5-A reductase Inh. (Finasteride Dutasteride) “Androgen Inhibitors” (suppresses growth)
A-1 blockers Tamsulosin, Terazosin, -zosin (m. relaxation)
“Only relieves symptoms”
Benign Prostatic Hyperplasia (BPH)
Asthma stages?
COPD Stages?
CHF Stages?
CKD Stages?
Asthma (FEV1 >80 normal decrease in 20s) X4 Stages
COPD (FEV1 > 80 normal decrease in 30s) X4
CHF (EF 55-70% normal decrease in 15s) X3
CKD (GFR >90 normal decrease in 30s) X4
Methotrexate is the DOC for ?
Rheumatoid Arthritis, Psoriatic Arthritis, Psoriasis, Juvenile Idiopathic Arthritis
Carbamazepine (Synthetic Benzo)
- Tic Dolorouxe
- Diabetes Insipidus
- Anticonvulsant/epileptic
MCC cancers are Adeno except for?
Ovarian- Epithelial
Vaginal- Squamous
Cervical- HPV
Bladder- Transitional cell
The common bleeding disorder where Desmopressin treatment will not work and will require_____ treatment/
Hemophilia B (Christmas) requires Factor IX