OBGYN Flashcards
Day 1-14 of menstrual cycle is called____________
_________ hormone predominates
Follicular/Proliferative phase
Estrogen predominates
Occurs after ovulation typically day 14 called_________
Progesterone is produced by the ____________
Luteal/Secretory Phase
Corpus Luteum
Normal menstrual cycle begins no earlier than____ days, and no later than____ days
Menstrual cycles lasts
21-35 days
3-7 days
Hormone that stimulates follicle growth–> Estrogen production
FSH
Hormone that stimulates ovulation secondary to ______ surge
LH (secondary to Estrogen surge)
_________ concentration of > 200pg/ml for 50 hours is required for _______ ________ to occur
Estrogen
LH surge to occur
Maintains the corpus luteum –> continuous Estrogen/progesterone support of endometrium.
HCG
No fertilization–> CL degeneration –> Dec. Est/Prog–> Menses
Menorrhagia is defined as
heavy menses
Dysmenorrhea is defined as
Menses with cramping
Metrorrhagia is defined as
intermenstrual periods
Precocious puberty occurs at what age?
< 8 yoa
Delayed Puberty is defined as ?
No Thelarche by 13
No menarche by age 16
Type of Amenorrhea where the patient previously had a menses, but stops for six months?
Secondary Amenorrhea
Primary amenorrhea is defined as ?
MCC Genetic or anatomic
Absence of menses by 16 w 2ndary Sex development.
Absence of 2ndary Sex development by age 14
Primary Amenorrhea MCC “GENETIC”: XO karyotype
Webbed neck, broad chest,
Turner’s Syndrome XO
Secondary amenorrhea MCC and 2nd MCC?
Pregnancy and weight changes
Other: hypothyroidism, PCOS, Cushing’s
In primary amenorrhea if uterus is absent “Empty Pouch” you associate amenorrhea with what disorders?
Mullerien Agenesis (46XX) (Ovaries w Labial fusion)
Androgen Insensitivity (46 XY) (Male w internal Genitals)
Disruption of hypothalamic secretion of GnRH–> Dec. FSH/LH: MCC is anorexia, exercise, celiac disease.
(Secondary Amenorrhea) Tx:
Hypothalamic Dysfunction (35%)
Clomiphene (Clomid- Stimulates Gonadotropin H.)
Decreased FSH/LH with Incr. prolactin you associate Secondary Amenorrhea with ?
Pituitary Dysfunction (Adenoma)
Increased FSH/LH with decreased estradiol you associate secondary amenorrhea with ?
Insulin resistant, obesity, Incr. testosterone, LH:FSH 3:1
PCOS
PCOS patient presentation ?
Hirsutism/Hyperandrogenism
Obesity
Ovarian cysts
Amenorrhea/Oligomenorrhea
Definition for prolonged time without menstrual bleeding
Oligomenorrhea
Definition for frequent menstrual bleeding
Polymenorrhagia
Types of menstrual disorders
Chronic Ovulation (Irregular: extreme ages young/old) "Unopposed estrogen"
Ovulatory (Regular cycles: “Prolonged progesterone”)
Tx: for both Menstrual disorders?
Tx: for severe bleeding?
OBC 1st Line (Thins endometrium: Regulates cycle)
Severe bleeding: High dose Estrogen or HD OBC
Sx= Definitive
Menorrhagia (heavy) common causes
Leiomyomas
Adenomyomas
Bleeding D/O
Hyperplasia/Carcinoma
Tender boggy enlarged uterus: Accompanied by dysmenorrhea and pelvic pain.
Tx:
Adenomyomas
Tx: Hysterectomy
Palpable irregular mass on uterine BM exam. Usually develops >30 y/o: Benign tumor (Non-tender)
Tx:
Leiomyoma (Uterine Fibroid)
Tx: Pre-menopause (Leuprolide) Definitive Hysterectomy
Menorrhagia cause by bleeding disorders such as ?
Von Willebrand, Thrombocytopenia, or platelet dysfx
Dysmenorrhea due to pelvic pathology: endometriosis or adenomyosis, leiomyomas..
Secondary Dysmenorrhea
Primary dysmenorrhea (not due to pathology) is MCC by increased_______–> increased muscle activity
usually starts when?
Prostaglandins
1-2 years post menarche in young females
Treatment for dysmenorrhea?
NSAIDS
OBC
Laparoscopy if all fail
Cluster of physical, behavioral, and mood changes during the luteal phase (1-2 weeks before menses).
Bloating, breast pain, headache, BM changes, fatigue, muscle aches, depression, hostility, Dec. Libido. TX:?
Premenstrual syndrome “Relieved 2-3 days onset of Per”
Tx: SSRIs or OBC (Drosperinone containing)
PCOS Dx: Tx:
Progesterone challenge 10mg Medroxyprog. X 10 days
(No withdrawal bleeding= Hypothalamus/Pituitary failure
or imperforated hymen)
Tx: 1.OBC 2.Spironolactone (Hirsutism)
3. Clomiphene (Ovulation) Metformin- Abn. FSH:LH
4. Weight-loss 5. Sx-restores ovulation
term for disorder of acquired scarring of the uterine cavity?
Asherman’s Disorder
Ectopic endometrial tissue that responds to cyclical hormones. Usually <35 yoa and nulliparity:
Ovaries MC site: –> infertility 25% Tx: X5 options
Endometriosis
Tx- Combined OCPS/NSAIDS
Progesterone- suppresses ovulation
Leuprolide- Suppreses FSH/LH
Danazol- Test induces pseudo-menopause
Laparoscopy ablation/Hysterectomy
C- section is biggest RF: post-partum/abortal:
“Foul smelling Lochia”, tachycardia, abdominal pain:
Tx:
Endometritis
Tx: Clindamycin + Gentamycin
Endometriosis Triad?
Dyspareunia, Dyschezia, Dysmenorrhea
MC Gynecologic malignancy U.S: MC post- menopausal. Estrogen dependent: combination OBC protective.
Menorrhagia/ Metrorrhagia: post-menopause bleeding:
Dx- Tx-
Endometrial Cancer
Dx: Endometrial Bx or TVUS E. Stripe > 4mm
Tx: Hysterectomy (Stage I), LAD excision (III), Chemo IV
Endometrial gland proliferation: Chronic hyperplasia 2T unopposed estrogen: pre-cancerous
Menorrhagia/ Metrorrhagia: post-menopause bleeding:
Dx- Tx-
Endometrial Hyperplasia
Dx- TVUS E. Stripe > 4mm Tx: Atypia- Hysterectomy
no Atypia- Progestin
MC type of cancer found in Endometrium
Adenocarcinoma 80%
Second MC gynecologic cancer w highest mortality: RF FmHX, nulliparity, infertility, BRCA-1/2, >50 YOA.
OCPs and high parity are protective. rarely s/sx ntil late in disease. Palpable ovary, ascites*, node (sister MJ)
Dx: Tx:
Ovarian Cancer
Dx: Biopsy Tx: Early: LAD-ectomy
Sx- CA-125 to monitor progress
Chemo
MC cancer in Ovaries?
Epithelial 90%
Most are asymptomatic: Common in reproductive years: usually unilateral, LLQ/RLQ pain, may rupture or torsion.
Mobile-adnexal mass,Abnormal bleeding, dyspareunia:
Dx: Tx:
Functional Ovarian Cyst (CL cyst fails to degenerate)
Dx: Pelvic US Tx: Supportive <8cm resolve
(US repeat in 6 weeks)
> 8cm= Laparoscopy
MC benign Ovarian neoplasm: removed to prevent Torsion or malignant transformation. calcified in Xray
Dermoid Cystic Teratoma
3rd MC gynecologic cancer that METS locally. RF incr. sexual activity, multiple partners.
Post coital bleeding/spotting MC sx, pelvic pain, watery DC, metrorrhagia. Dx: Tx
Cervical Carcinoma
Dx: Colposcopy w biopsy/PAP/cytology Tx: Dep. Stage
MC cervical cancer?
Squamous 90% (Adenocarcinoma-10%)
Cervical cancer MCC?
Prevention?
HPV- 16 and 18 (31-33)
Prevention- Gardasil and Gardasil 9 <15 YOA X2 doses
>15 YOA X3 doses
Cervical screening cancer guidelines
Start: 21 YOA DC: 65
21-29 YOA: Every 3 years
> 30 YOA: Co-Test Q 5 years
PAP smear cervical cytology results
HPV positive and
Negative for intraepithelial malignancy (no neoplasia)
if >25 YOA- Cytology and HPV testing in 12 months
or Genotype for HPV 16 and 18
PAP smear cervical cytology results
Squamous cell Abn.- ASC-US (Undetermined sig.)
HPV Negative? HPV Positive
> 25 YOA- HPV Negative- repeat PAP/Co test in 3years
Positive- colposcopy w Bx
Or repeat PAP in 1 year
PAP smear cervical cytology results
ASC-H (cant exclude high intraepithelial lesion) HSIL
Colposcopy (Acetic acid accentuation of lesion)
PAP smear cervical cytology results Dx: Tx:
LSIL (Low grade intraepithelial lesion) CIN I
> 30 YOA HPV neg/positive?
25-29 YOA- Colposcopy w biopsy
> /= 30 YOA- HPV negative=repeat cytology x1 year
positive= colposcopy w biopsy
Tx: LEEP or Cold Knife conization
PAP smear cervical cytology results Dx: Tx:
HSIL (CIN II, III, carcinoma in situ)
Colposcopy w biopsy in all ages
Tx: Tx: LEEP or Ablation (cautery)
inability to maintain pregnancy 2T premature cervical dilation. Vaginal bleeding/DC in 2 trimester. painless
Tx:
Cervical Insufficiency (Incompetent cervix
Tx: Cerclage (suture of cervical OS) and bedrest
tender gland enlargement, unilateral vulvar mass (Inferior vulva) may be to E. Coli, staph or gonorrhea.
Non-tender in non-infected
Bartholin Cyst/Abcess
MC cancer of the vulva?
MC presentation
Squamous 95%
Pruritus (Red-white ulcerative crusted lesions)
Vaginal dryness, dyspareunia, vaginal inflammation, infection, recurrent UTI.
Tx
Vulvovaginal Atrophy
Tx: Vaginal Estrogens
Ospemifene- estrogen agonist in vagina and bone
Increased FSH/LH with decreased estrogen–> cessation of menses for > 1year. Dx Tx?
Hot flashes, menses alterations, mood changes, hyperlipidemia, osteoporosis, dyspareunia, incontinence
Menopause
Dx- FSH essay most sensitive test > 30 IU/ml
Increased FSH/LH w decreased Estrogen
Tx- Estrogen + Progesterone, Ca2+ vit. D, Hysterectomy
Palpable mass on ovary: associated with endometriosis.
“Chocolate cysts”
Endometrioma
MC breast D/O: Tender, BL, multiple, mobile. Fluid filled 2T exaggerated response to hormones. 30-50 YOA
Dx: TX:
Fibrocystic Breast D/O
DX: US or FNA Tx; Self resolve or FNA
2nd MC benign breast D/O: non-tender, mobile, rubbery lump. may enlarge w pregnancy. Gradual growth
Teens to early 20s Dx: Tx:
Fibroadenoma of breast
Dx: None Tx: Self resorb (No Sx needed)
Inflammation of the breast. Mostly in lactating women. S. Aureus MC. UL breast pain. tender warm + nipple DC
induration and fluctuance. Dx: Tx:
Mastitis/ Breast Abscess
Dx: Clinical Tx: Warm compress, nurse, Diclox/Nafcillin
Breast Abscess DC feeding and I/D
Breast cancer types
Ductal Carcinoma-
Lobular carcinoma-
Medullary, Tubular, Metastatic, Mucinoid
Does not penetrate the basement membrane. Associated with lymphatic METS esp. axillary MC 75-80%
Ductal Carcinoma In Si Tu
may not progress but associated with risk of invasive breast cancer.
Lobular Carcinoma
Breast cancer clinical manifestations
Breast mass- painless, hard, fixed
skin changes- redness, skin retraction, inverted nipple
itchiness, peau de orange
MC location of breast cancer?
Upper outer quadrant
Diagnosis initial SOC < 40?
DX if highly suspicious of malignancy?
Initial-US (Best <40 YOA)
Mammogram (High suspicion) and Bx
Breast cancer staging
Stage 0: DCIS, LCIS, precancerous
Stage I-III: w/I breast/regional lymph node
Stage IV: Metastatic BC
Neoadjuvent Hormone therapy
Anti-estrogen
Aromatase inhibitor (Decr. Estrogen production)
Monoclonal Ab Tx- HER2 G-factor (+)
Adjuvent therapy
Lumpectomy-
Mastectomy-
SLND (Sentinel Lymph node dissection)
Lower abdominal pain, dyspareunia, fever, purulent DC, Adnexal tenderness, WBC> 10K, (+) chandelier’s
(+) Cervical motion tenderness: Ascending infx of reproductive tract. Dx: Tx:
Pelvic nflammatory disease
Dx: HcG R/O Ecto Prego
Tx: OP- Doxy, Ceftr, Metro
IP- IV doxy, Cefotetan, vanc/Gent
What is Fitz-Hugh Curtis Syndrome ?
RUQ pain associated with hepatic fibrosis and peritoneal involvement of PID. Normal LFTs
“peri-hepatitis”
Exotoxin producing S. Aureus. seen with tampon use or diaphragm sponge > 24 hours. Tx:
Sudden onset high fever: diffuse erythematous macular rash, fever 102.2, tachycardia, desquamation. HYTN
Toxic Shock Syndrome
Tx: Vancomycin + Gentamycin
Frothy yellow green DC: Strawberry cervix: pH > 5
Mobile protozoa;
Dx: Tx:
Trichomoniasis
Dx: Wet mount Mobile Tx: Metronidazole 2 G X1
500 mg BID X 7days
(Tinidazole next line)
Thin watery Grey white DC: Fishy odor rotten smell: Clue cells bacteria covered: pH >4.5: (____ criteria)
Dx: Tx:
Bacterial Vaginosis (Amsel Criteria)
Dx: KOH prep Tx: Metronidazole I-vag X 7days
Vancomycin next line
Vaginal vulvar erythema, swelling, itchiness, burning when urine touches. Dysuria/dyspareunia. pH <4. 5
Dx: Tx:
Candidiasis
Dx: Yeast/spores KOH Tx: I- vag Clotri/Mico or nystatin
Long Acting progestins that last 3 years: least failure rate: –>osteoporosis;
Etonogestrel (Implanon)
Long Acting progestins that last 3 months: least failure rate: –>osteoporosis; Infertility up to 2 years
Medroxyprogesterone (Depo-Provera) Injectable
applied every week X3 weeks not used x1 week. Better compliance. less effective is patient is underweight
Ethinyl Estradiol/ Norelgestromin (Ortho-Evra Patch)
applied X3 weeks with 1 week off; removed during intercourse but must be replaced within 3 hours
Etonogestrel /Estradiol (Nuva-ring)
Progestin only: safe during lactation: Decreases endometrial cancer: less PID. Incr ectopic prego
“Mini-Pill”
Most effective form of contraception: 5 year duration: increased risk of PID
Levonorgestrel (Mirena) IUD
10 year duration of action. no hormonal use: Increased risk of PID
Copper (Paragard)
Beneficial if taken w/I 72 hours of unprotected sex
Levonorgestrel X2 0.75mg 12 hours apart or
Levonorgestrel X1 1.5mg dose
Emergency contraception of up to 120 hrs within intercourse?
Ulipristal Acetate (Ella)
Emergency contraception within 5 days of intercourse?
Copper IUD ( Paragard)
In obstetrics, what is Ladin’s sign?
Uterus softening after 6 weeks
What is Hegar’s sign ?
uterus isthmus softening after 6-8 weeks
What is Goodell’s sign
Cervical softening due to incr. vascularization 4-5 weeks gestation
what is chadwick’s sign ?
bluish coloration of the cervix and vulva 8-12 weeks
Fetal hart tones will be heard at how many weeks ?
What is the normal rate?
10-12 weeks EGA
120-160
At what EGA will the patient feel fetal movements?
16-20 weeks
heart beat with US can be seen at what EGA?
5-6 weeks
Rhogam testing is conducted when?
@ 28 weeks and within 72 hours of birth
Highest risk factors for Ectopic pregnancy?
History of prior ectopic pregnancy
Previous Abdominal/ Tubal surgery or PID (adhesions)
Ectopic Pregnancy triad?
- Unilateral pelv/abd pain
- Vaginal bleeding
- Amenorrhea
severe abdominal pain, dizziness, NV, signs of shock, syncope, tachycardia, and hypotension are assoc. with?
Ectopic Pregnancy Rupture
How is the diagnosis and what is the treatment of Ectopic pregnancy?
Dx: 1. Serial HcGs q 2-3 days
2. TVUS- empty Gestational sac, Non- IUP, HcG > 2K
Tx: Unruptured: Methotrexate: Stable, <4cm, HcG < 5K
(+ leucovorin= Multi dose)
Rutured: Salpingostomy 1st choice
Type of abortion where- Some Products of conception expelled, some retained and presence of Dilation?
Incomplete Spontaneous Abortion
Dilation and Evacuation with all retained abortions
(Also- Rhogam if mom is Rh - )
Type of abortion where- NO Products of conception expelled, some retained and presence of progressive Dilation?
Inevitable Spontaneous Abortion
Type of abortion where- NO Products of conception expelled and the cervical OS is closed?
Threatened Spontaneous Abortion
Type of abortion where- All Products of conception expelled and cervical OS is closed?
Complete Spontaneous Abortion
Type of abortion where- NO Products of conception expelled and cervical OS is closed?
Missed Spontaneous Abortion
Foul brownish discharge, fevers, chills. Some POC retained Cervical OS closed with cervical motion T.?
Septic Spontaneous Abortion (BS ABX)
defined as HTN without proteinuria after 20 weeks EGA resolving w/I 12 weeks PP?
Transitional (Gestational) HTN
defined as HTN + proteinuria +/- edema >20 wks EGA. Thrombocytopenia
Proteinuria >300mg (> 5G=severe): BP >140/90 twice 6 hours apart but not over week. Tx: ?
Pre-eclampsia
Tx: Mild- Delivery >/= 37 weeks: < 34= bed rest daily BP
Severe- Prompt Delivery only cure
HTN + Thrombocytopenia + Proteinuria + Seizures or Coma
Tx:?
Eclampsia
Tx:Magnesium Sulfate
Lorazepam (2nd Line) “Delivery once stable”
Treatment of HTN for Pre-eclampsia/Eclampsia?
Hydralazine, Labetalol ( or Nifedipine for Pre-)
Treatment of HTN for pregnancy with BP 150/100?
Methyldopa (TOC)
Labetalol ( Hydralazine or Nifedipine)
3rd trimester sudden onset of painless bright red bleeding. No abd. pain or uterine tenderness.
No fetal distress: Dx: Tx?
Placenta Previa
Dx: US localizes placenta
Tx: Admit 1. Mag Sulfate inhibits contractions
2. CS given between 24-34 weeks (Lungs)
3. Delivery when stable
3rd trimester sudden onset of painful dark red bleeding. Severe abd. pain or uterine tenderness/ rigidity:
Fetal distress (Bradycardia) Dx: TX:
Abruptio Placenta
Dx: US ( NO pelvic exam)
Tx: Stabilize (hemodynamically) Immediate Delivery
What is the MCC of Abruptio Placenta ?
Maternal HTN
how do you diagnose Gestational Diabetes?
How do you confirm Gestational Diabetes?
50 G Oral Glucose challenge test @ 24-28 EGA Confirm: 100G 3 hours Oral GTT (GS) fasting @ a.m (>140 in 1 hour)–>
1 hour= >180 3 hours> 140 fasting> 95
What is the treatment of choice for Gestational Diabetes?
Insulin (0.8 IU/kg 1st Tri.) then 1.0, then 1.2 IU
Labor induction @ 38 weeks
Post-Partum depression occurs within______ PP?
2 weeks-2months PP
Post-Partum blues occurs within _______ PP?
2-4 days PP
Major-Depression occurs > ______ PP?
2 months (2 weeks- 12 months)
Painless vaginal bleeding, uterine size/date mismatch, Hyperemesis gravidarum.
B-HcG markedly elevated > 100K: US- snowstorm “Cluster of grapes” Tx:
Gestational Trophoblastic Disease (Molar Pregnancy)
Tx: Surgical Uterine evacuation (Suction Curettage)
METS- Chemotherapy (Methotrexate)
“No pregnancy for a year”
Neoplasm due to abnormal placental development with trophoblastic tissue from gestational tissue? 80% benign
Hydatidiform Mole
What are the two types of Hydatidiform Mole?
Complete- 46 XX all paternal
Incomplete- Eggs fertilized by 2 sperm
What does Dizygotic gestation mean?
Fertilization of two Ova by 2 different sperm (Fraternal)
What does Monozygotic gestation mean?
Fertilization of one ovum (Identical)
Hemolytic anemia, jaundice, kernicterus, hepatosplenomegaly that can lead to Hydrops Fetalis?
Rh alloimmunization
Preventive management of Rh alloimmunization?
- Rhogam @ 28 weeks EGA
- Rhogam within 72 hours of delivery
- Rhogam if any potential cross mix blood (Trauma)
Severe, excessive morning sickness (with NV) associated with weight loss or electrolyte imbalance
Persists >16 weeks EGA Tx:
Hyperemesis Gravidarum
Tx: High protein foods: small frequent meals: Parenteral nutrition if severe: Pyridoxine (B6)+ Doxylamine 1st
(Promethazine dimenhydrinate)
Stages of Labor
Stage I- Cervix dilation (Latent-effacement Active- 3-4cm dilation)
Stage II- Cervical dilation to delivery of fetus
Stage III- Delivery of placenta and after birth
Stages of Delivery
Delivery of Fetus
Passive phase- complete dilation to mother expulse efforts
Active phase- Mother expulse efforts to fetal delivery
Three signs of placental separation? (0-30 minutes)
- Gush of blood
- Lengthening of Umbilicus
- Firm Fundus
MCC of post-partum hemorrhage >500ml
Tx:
Uterine Atony (Non contracting- soft boggy uterus)
Tx: Uterine massage: Oxytocin: Misoprostol: Methylergonovine
Premature Rupture of membranes Diagnosis?
- Nitrazine (Blue paper test)- pH >6.5
- Fern Test: Crystallization of Estrogen/Amniotic fluid
- US
- Fetal Fibronectin present (pre-term)
Causes of Premature Rupture of membranes
prior preterm delivery, STDs, smoking
Premature labor is defined as ?
What dilation and effacement?
Regular contractions (>4-6 hours) w progressive cercival changes before 37 weeks.
> 3cm dilation > 80 effacement
Tocolytics that suppress uterine contractions?
- Indomethacin
- Nifedipine (CCBs)
- Magnesium sulfate
- Beta2 agonist Terbutaline
Group B strep ABX prophylaxis?
Ampicillin –> then Amoxicillin and Azytrhomycin
PCN- Cephazolin –> cephalexin and Azytrhomycin
Dystocia causes 3 Ps
Power- weak/absent contraction
Passenger- size/position
Passage- uterus/ soft tissue abnormalities
Nonmanipulative management that increases pelvic opening with hyperflexion
Mc Robert’s maneuver
Manipulative management that requires fetal 180 shoulder rotation
Corkscrew maneuver
Induction of labor management? (Early and late)
Early- Cervidil- Prostaglandin Gel: Balloon (Laminaria)– cervical ripening
Late- <1 cm : IV Oxytocin: Amniotomy (Rupture) cervix partially dilated
Daily recommended Vitamin D and calcium
Calcium: 1000 mg/day for women up to 50 and men up to 70, (1200 mg/day for older adult)
Vit. D: Adults: 800-2000 IU/day (400 kids/adolescent)
Dexa scan normal limits? Osteoporosis Dexa scan?
- Normal – T score of +1.0 to -1.0
- Osteopenia – T score of -1.0 to -2.5
-Osteoporosis – T score of
End Due Date Nagele’s ?
add 7 days and subtract 3 months to 1st day of LMP
Thought to be a form of severe pre-eclampsia that occurs in 10% of pre-eclamptic patients
can occur in the absence of elevated BP
HELLP Syndrome
What does HELLP syndrome stand for?
Hemolysis, Elevated Liver enzymes and Low Platelets
summation of the largest cord-free vertical pockets in each of the four quadrants of an equally divided uterus
Amniotic Fluid Index
Greatest Breast cancer RFs?
Age: BRCA1/2 1st relative: Nulliparity: Menarchy <12:
USPTF recommendations for Breast cancer screening?
> 50-74 : Biennial Mammography
BRCA1/2: @ 25 Annual