OBGYN Flashcards
Day 1-14 of menstrual cycle is called____________
_________ hormone predominates
Follicular/Proliferative phase
Estrogen predominates
Occurs after ovulation typically day 14 called_________
Progesterone is produced by the ____________
Luteal/Secretory Phase
Corpus Luteum
Normal menstrual cycle begins no earlier than____ days, and no later than____ days
Menstrual cycles lasts
21-35 days
3-7 days
Hormone that stimulates follicle growth–> Estrogen production
FSH
Hormone that stimulates ovulation secondary to ______ surge
LH (secondary to Estrogen surge)
_________ concentration of > 200pg/ml for 50 hours is required for _______ ________ to occur
Estrogen
LH surge to occur
Maintains the corpus luteum –> continuous Estrogen/progesterone support of endometrium.
HCG
No fertilization–> CL degeneration –> Dec. Est/Prog–> Menses
Menorrhagia is defined as
heavy menses
Dysmenorrhea is defined as
Menses with cramping
Metrorrhagia is defined as
intermenstrual periods
Precocious puberty occurs at what age?
< 8 yoa
Delayed Puberty is defined as ?
No Thelarche by 13
No menarche by age 16
Type of Amenorrhea where the patient previously had a menses, but stops for six months?
Secondary Amenorrhea
Primary amenorrhea is defined as ?
MCC Genetic or anatomic
Absence of menses by 16 w 2ndary Sex development.
Absence of 2ndary Sex development by age 14
Primary Amenorrhea MCC “GENETIC”: XO karyotype
Webbed neck, broad chest,
Turner’s Syndrome XO
Secondary amenorrhea MCC and 2nd MCC?
Pregnancy and weight changes
Other: hypothyroidism, PCOS, Cushing’s
In primary amenorrhea if uterus is absent “Empty Pouch” you associate amenorrhea with what disorders?
Mullerien Agenesis (46XX) (Ovaries w Labial fusion)
Androgen Insensitivity (46 XY) (Male w internal Genitals)
Disruption of hypothalamic secretion of GnRH–> Dec. FSH/LH: MCC is anorexia, exercise, celiac disease.
(Secondary Amenorrhea) Tx:
Hypothalamic Dysfunction (35%)
Clomiphene (Clomid- Stimulates Gonadotropin H.)
Decreased FSH/LH with Incr. prolactin you associate Secondary Amenorrhea with ?
Pituitary Dysfunction (Adenoma)
Increased FSH/LH with decreased estradiol you associate secondary amenorrhea with ?
Insulin resistant, obesity, Incr. testosterone, LH:FSH 3:1
PCOS
PCOS patient presentation ?
Hirsutism/Hyperandrogenism
Obesity
Ovarian cysts
Amenorrhea/Oligomenorrhea
Definition for prolonged time without menstrual bleeding
Oligomenorrhea
Definition for frequent menstrual bleeding
Polymenorrhagia
Types of menstrual disorders
Chronic Ovulation (Irregular: extreme ages young/old) "Unopposed estrogen"
Ovulatory (Regular cycles: “Prolonged progesterone”)
Tx: for both Menstrual disorders?
Tx: for severe bleeding?
OBC 1st Line (Thins endometrium: Regulates cycle)
Severe bleeding: High dose Estrogen or HD OBC
Sx= Definitive
Menorrhagia (heavy) common causes
Leiomyomas
Adenomyomas
Bleeding D/O
Hyperplasia/Carcinoma
Tender boggy enlarged uterus: Accompanied by dysmenorrhea and pelvic pain.
Tx:
Adenomyomas
Tx: Hysterectomy
Palpable irregular mass on uterine BM exam. Usually develops >30 y/o: Benign tumor (Non-tender)
Tx:
Leiomyoma (Uterine Fibroid)
Tx: Pre-menopause (Leuprolide) Definitive Hysterectomy
Menorrhagia cause by bleeding disorders such as ?
Von Willebrand, Thrombocytopenia, or platelet dysfx
Dysmenorrhea due to pelvic pathology: endometriosis or adenomyosis, leiomyomas..
Secondary Dysmenorrhea
Primary dysmenorrhea (not due to pathology) is MCC by increased_______–> increased muscle activity
usually starts when?
Prostaglandins
1-2 years post menarche in young females
Treatment for dysmenorrhea?
NSAIDS
OBC
Laparoscopy if all fail
Cluster of physical, behavioral, and mood changes during the luteal phase (1-2 weeks before menses).
Bloating, breast pain, headache, BM changes, fatigue, muscle aches, depression, hostility, Dec. Libido. TX:?
Premenstrual syndrome “Relieved 2-3 days onset of Per”
Tx: SSRIs or OBC (Drosperinone containing)
PCOS Dx: Tx:
Progesterone challenge 10mg Medroxyprog. X 10 days
(No withdrawal bleeding= Hypothalamus/Pituitary failure
or imperforated hymen)
Tx: 1.OBC 2.Spironolactone (Hirsutism)
3. Clomiphene (Ovulation) Metformin- Abn. FSH:LH
4. Weight-loss 5. Sx-restores ovulation
term for disorder of acquired scarring of the uterine cavity?
Asherman’s Disorder
Ectopic endometrial tissue that responds to cyclical hormones. Usually <35 yoa and nulliparity:
Ovaries MC site: –> infertility 25% Tx: X5 options
Endometriosis
Tx- Combined OCPS/NSAIDS
Progesterone- suppresses ovulation
Leuprolide- Suppreses FSH/LH
Danazol- Test induces pseudo-menopause
Laparoscopy ablation/Hysterectomy
C- section is biggest RF: post-partum/abortal:
“Foul smelling Lochia”, tachycardia, abdominal pain:
Tx:
Endometritis
Tx: Clindamycin + Gentamycin
Endometriosis Triad?
Dyspareunia, Dyschezia, Dysmenorrhea
MC Gynecologic malignancy U.S: MC post- menopausal. Estrogen dependent: combination OBC protective.
Menorrhagia/ Metrorrhagia: post-menopause bleeding:
Dx- Tx-
Endometrial Cancer
Dx: Endometrial Bx or TVUS E. Stripe > 4mm
Tx: Hysterectomy (Stage I), LAD excision (III), Chemo IV
Endometrial gland proliferation: Chronic hyperplasia 2T unopposed estrogen: pre-cancerous
Menorrhagia/ Metrorrhagia: post-menopause bleeding:
Dx- Tx-
Endometrial Hyperplasia
Dx- TVUS E. Stripe > 4mm Tx: Atypia- Hysterectomy
no Atypia- Progestin
MC type of cancer found in Endometrium
Adenocarcinoma 80%
Second MC gynecologic cancer w highest mortality: RF FmHX, nulliparity, infertility, BRCA-1/2, >50 YOA.
OCPs and high parity are protective. rarely s/sx ntil late in disease. Palpable ovary, ascites*, node (sister MJ)
Dx: Tx:
Ovarian Cancer
Dx: Biopsy Tx: Early: LAD-ectomy
Sx- CA-125 to monitor progress
Chemo
MC cancer in Ovaries?
Epithelial 90%
Most are asymptomatic: Common in reproductive years: usually unilateral, LLQ/RLQ pain, may rupture or torsion.
Mobile-adnexal mass,Abnormal bleeding, dyspareunia:
Dx: Tx:
Functional Ovarian Cyst (CL cyst fails to degenerate)
Dx: Pelvic US Tx: Supportive <8cm resolve
(US repeat in 6 weeks)
> 8cm= Laparoscopy
MC benign Ovarian neoplasm: removed to prevent Torsion or malignant transformation. calcified in Xray
Dermoid Cystic Teratoma
3rd MC gynecologic cancer that METS locally. RF incr. sexual activity, multiple partners.
Post coital bleeding/spotting MC sx, pelvic pain, watery DC, metrorrhagia. Dx: Tx
Cervical Carcinoma
Dx: Colposcopy w biopsy/PAP/cytology Tx: Dep. Stage
MC cervical cancer?
Squamous 90% (Adenocarcinoma-10%)
Cervical cancer MCC?
Prevention?
HPV- 16 and 18 (31-33)
Prevention- Gardasil and Gardasil 9 <15 YOA X2 doses
>15 YOA X3 doses
Cervical screening cancer guidelines
Start: 21 YOA DC: 65
21-29 YOA: Every 3 years
> 30 YOA: Co-Test Q 5 years
PAP smear cervical cytology results
HPV positive and
Negative for intraepithelial malignancy (no neoplasia)
if >25 YOA- Cytology and HPV testing in 12 months
or Genotype for HPV 16 and 18
PAP smear cervical cytology results
Squamous cell Abn.- ASC-US (Undetermined sig.)
HPV Negative? HPV Positive
> 25 YOA- HPV Negative- repeat PAP/Co test in 3years
Positive- colposcopy w Bx
Or repeat PAP in 1 year
PAP smear cervical cytology results
ASC-H (cant exclude high intraepithelial lesion) HSIL
Colposcopy (Acetic acid accentuation of lesion)
PAP smear cervical cytology results Dx: Tx:
LSIL (Low grade intraepithelial lesion) CIN I
> 30 YOA HPV neg/positive?
25-29 YOA- Colposcopy w biopsy
> /= 30 YOA- HPV negative=repeat cytology x1 year
positive= colposcopy w biopsy
Tx: LEEP or Cold Knife conization
PAP smear cervical cytology results Dx: Tx:
HSIL (CIN II, III, carcinoma in situ)
Colposcopy w biopsy in all ages
Tx: Tx: LEEP or Ablation (cautery)
inability to maintain pregnancy 2T premature cervical dilation. Vaginal bleeding/DC in 2 trimester. painless
Tx:
Cervical Insufficiency (Incompetent cervix
Tx: Cerclage (suture of cervical OS) and bedrest
tender gland enlargement, unilateral vulvar mass (Inferior vulva) may be to E. Coli, staph or gonorrhea.
Non-tender in non-infected
Bartholin Cyst/Abcess
MC cancer of the vulva?
MC presentation
Squamous 95%
Pruritus (Red-white ulcerative crusted lesions)
Vaginal dryness, dyspareunia, vaginal inflammation, infection, recurrent UTI.
Tx
Vulvovaginal Atrophy
Tx: Vaginal Estrogens
Ospemifene- estrogen agonist in vagina and bone
Increased FSH/LH with decreased estrogen–> cessation of menses for > 1year. Dx Tx?
Hot flashes, menses alterations, mood changes, hyperlipidemia, osteoporosis, dyspareunia, incontinence
Menopause
Dx- FSH essay most sensitive test > 30 IU/ml
Increased FSH/LH w decreased Estrogen
Tx- Estrogen + Progesterone, Ca2+ vit. D, Hysterectomy