Subfertiltiy: Endometriosis Flashcards

1
Q

What is endometriosis ?

A

Endometriosis is the presence of tissue that normally grows inside the uterus i.e, endometriotic tissue, outside of it

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2
Q

Endometriosis is hormonally driven, i.e. by …. and so affects women of reproductive age that … ?

A

Endometriosis is hormonally driven, i.e. by oestrogen and so affects women of … reproductive age that … ?

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3
Q

What are the 3 theories behind endometriosis?

A
  1. Retrograde menstruation that implants, 2. Metaplasia of mesothelial cells, 3. Impaired immunity
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4
Q

There may be genetic susceptibility, is this true ?

A

Yes

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5
Q

What are the 3 common sites for endometriosis ?

A

Uterosacral ligaments, ovaries and Pouch of Douglas

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6
Q

What is the mnemonic for the symptoms of endometriosis?

A

CDS

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7
Q

What are the symptoms for endometriosis, including main and associated ? (7)

A

Cyclical pain prior to menstruation, chronic pelvic pain, dysmenorrhea and deep dyspaenuria; dyschezia with/without rectal pain or bleeding and dysuria; Subfertilty

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8
Q

What examination would you do in a patient suspected of endometriosis?

A

Bimanual vaginal examination

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9
Q

What is a classical sign found on examination in a patient with endometriosis?

A

A fixed and retroverted uterus is a classical sign of endometriosis

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10
Q

What will you find on palpation of uterosacral ligaments ? (2)

A

Adnexal tenderness or mass on palpation of uterosacral ligaments

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11
Q

What is the gold standard for diagnosis of endometriosis?

A

Laparoscopy with/without a biopsy for histological confirmation

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12
Q

What 2 other tests can you do in endometriosis ?

A

TVUSS and MRI

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13
Q

What is the purpose of performing a TVUS in a patient with endometriosis ?

A

TVUSS to exclude cancers (endometrial/cervical) and ovarian cysts/abscess

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14
Q

What is the purpose of performing an MRI in patient with endometriosis?

A

To detect extent of endometriosis

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15
Q

What chemical is increased in endometriosis but is not used as a screening tool ?

A

CA125

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16
Q

Treatment of endometriosis depends on 3 things, what are they ?

A

Severity, pain and subfertility

17
Q

Can you treat endometriosis empirically without a laparoscopic diagnosis if fertility is not the issue ?

A

Yes

18
Q

What can you treat endometriosis empirically without a laparoscopic diagnosis ?

A

COCP or Progestogens

19
Q

What is first line medical treatment for endometriosis (3) and (1) medical treatment can be used short-term (<6months) and must be followed with HRT ?

A

COCP, progestogens (oral, IM or SC), Mirena IUS and GnRH analogues used short term <6 months a must be followed with HRT

20
Q

What medical treatment is also used in subfertile couples but does not generally improve fertility?

A

GnRh analogues

21
Q

What is important to note about medical treatment for endometriosis after its cessation?

A

It will comeback

22
Q

When is surgical treatment used ?

A

If medical treatment fails

23
Q

What is the mnemonic for techniques that can be performed under laparoscopy ? (3)

A

ACE

24
Q

The common surgical procedures performed for endometriosis is laparoscopy. What techniques can be performed under laparoscopy ? (3)

A

ACE: Ablation, coagulation and excision

25
Q

Laparoscopy can be performed with/without what surgical produce?

A

Adenolysis

26
Q

What other surgical procedure can be performed and why is it performed ?

A

Ovarian cystectomy for excision of endometrial cysts (chocolate cysts)

27
Q

What surgical procedure is used as the last resort for endometriosis ?

A

Total hysterectomy and bilateral salpingo-oophrectomy

28
Q

What Surgery is performed for older women with severe endometriosis ?

A

Total hysterectomy and bilateral salpingo-oophrectomy

29
Q

What surgery can be used to improve fertility in endometriosis ?

A

Laparoscopic ablation with/without adenolysis

30
Q

Medical treatment does not generally improve what ?

A

Medical treatment does not generally improve fertility