Subfertility Flashcards
what is the WHO definition of infertility?
failure to achieve clinical pregnancy after 12 months or more of regular unprotected sexual intercourse (in absence of known reason) in a couple who have never conceived a child
where are sertoli cells found?
in the seminiferous tubules of the testes
which cell creates the blood testes barrier and what do this barrier do?
sertoli cells
protects the spermatozoa from antibodies and ensures the fluid composition within the testes is suitable for development of the sperm
what do the sertoli cells provide for the developing cells?
nutrients, destory defective sperm and remove excess cytoplasm from the seminiferous tubules
what do sertoli cells secrete?
seminiferous tubule fluid
androgen binding globulin
inhibin hormone
activin hormone
what does seminiferous tubule fluid do?
essential for carrying spermatozoa to epididymis
what does androgen binding globulin do?
essential for sperm production (binds testosterone)
what do inhibin and activin hormones do?
essential for regulation of FSH secretion and contorl of spermatogenesis
where does spermatogensis occur?
inside the seminiferous tubules
where are developing sperm stored?
epididymis
what is the vas deferens?
a muscular tube that transports te spermatozoe from the epididymis through the spermatic cord, through the inguinal canal, past the bladder and to join the seminal vesicle and forms the ejaculatory duct
what is the function of the bulbourethral gland (cowper’s gland)?
produces and releases fluid which lubricates urethra and neutralises any acidity, prior to ejaculation
what is the function of the seminal vesicle?
produces and releases majority of seminal fluid containing
- fructose (nourishes sperm cells)
- prostaglandins (triggers contraction of vaginal muscles for sperm motility)
- fibrinogens (clot precursors)
what is the function of the prostate gland?
produces and releases
- acid phosphatase
- citric acid
- inositol
- calcium, zinc and magnesium
what is the hormonal control of spermatogensis?
- GnRH is released in bursts every 2-3 hours from the hypothalamus
- GnRH stimulates the Ant Pit to release LH and FSH
- LH stimulations testosterone secretion from leydig cells
- testosterone and FSH surges stimulate spermatogenesis with seminiferous tubules
- inhibin released from sertoli cells decreases secretion of FSH and testosterone released from the Leydig cells decreases the release of GnRH adn therefore, decreases LH, providing negative feedback, inhibiting spermatogenesis