Stuff Flashcards
Statins with interactions
Lovastatin, simvastatin
Bile acid sequestrants can increase what?
TG
Fibrate lipid effects
Decrease TG, can increase ldl
Colchicine interaction
Fibrates and statins
Which fish oil does not increase ldl?
Vascepa (icosapent ethyl)
Cholesterol meds that cause liver damage
Statins, fibrates, zetia, niacin
Not bile acid sequestrants
When are fish oil products used ?
TG > 500
Lipid drugs
Clevidipine 2 kcal/ mL
Propofol 1.1 kcal/ mL
Olmesartan unique adr
Sprue like enteropathy - severe chronic diarrhea- can happen anytime after starting
What can’t be used with ace/arb
Neprilysin inhibitor (sacubitril)- do not confuse with aloskiren (tekturna)- can use with tekturna in patients with diabetes
Lithium interaction
diuretics and ace/ arb- reduced lithium clearance
Spiromolactone vs eplerenone
Spir is non selective aldosterone blocker and blocks androgen
Where do aldosterone blockers work
Collecting ducts and distal tubule
Beta blockers with intristic sympathomimetics activity - not recommended in post MI
Ace, pin, pen
Methyldopa fun facts
CI liver dx, and mao inhibitors
Hemolytic anemia
Lupus
Nitrate /pde5I separation
Avanafil- 12 h
Sildenafil/vardenafil- 24 h
Tadalafil- 48 h
Clopidigrel ADR
Thrombotic Thrombocytopenic purpura
How long to DC antiplatelet before surgery
5 days
Preferred anticoagulant for stemi
Bibalirudin
Is AC required after ACS
No- warfarin if Afib though
Don’t confuse with stroke recs
Weird cardio meds that trip me up
Ranolazine (ranexa)- late na channel inhibitor- angina. QTc, no effect on HR/BP
Ivravidine (corlanor)-funny channel- HF. QTc, decrease HR and increase BP
Vorapaxar (zontivity)- PAR- ACS. More of an antiplatelet- no worry of QTc, HR/ BP
Washout from ARB to neprilysin inhibitor (entresto)
None!
36 hours for AceI
Which form of isosorbide is preferred in HF?
Dinitrate- only one studied
What causes digoxin toxicity?
HypoK, hypoMG, hyperCa2+
Hypothyroidism, p-gp inhibitor
dehydration!!!!
Potassium strength: KCl 10%
20 meq/15 mL
Which azole does NOT prolong QTc ?
Isavuconazole
Which SSRI preferred in cardiac pts?
Sertraline (less risk QTc)
When are mexilitene and lidocaine used ?
Ventricular arrithmias only
Procainamine vs propafenone
Procainamide is 1a propafenone is 1c (not used)
When are non-DHPs CI?
Reduced ejection fraction HF
Amiodarone
It’s an antiarrythmic that is safer in HF (probably why used more than other)
Dig is used for both!
Amiodarone less known drug interaction
Sofosbuvir- bradycardia
DNE simvastatin 20 mg or lovastatin 40 mg
All CCBs are..?
Cyp 3A4 substrates
Verap and dilt are p-gp substrates too
Non-DHP drug interactions
They inhibit CYP3A4- lower simvastatin and lovastatin
Also substrates of 3A4 and pg-p
Amiodarone vs multaq (dronedarone)
Dronedarone has no iodine so no thyroid problems, but it’s much more liver toxic
Dig organ concerns
Renal NOT liver
Crcl <50 decrease!
Amiodarone organ concerns
Liver NOT renal
*also lung/thyroid
ASA for stoke
Give 24-48 h after but NOT within 24 h of tPa
DAPT duration
ACS- at least 12 months
Stroke- 21 days (risk hemorrhage)
Cardioembolic vs non cardioembolic stroke
Cardio- anticoagulation
Non-cardio- antiplatelet
Aggrenox indication
Stroke but probably not ACS (does not contain enough ASA)
SE: HA (vasodilation)
Which is the only oral direct thrombin inhibitor?
Dabigatran (pradaxa)
IVs: argatroban, bivalirudin
Xarelto dosing
20 with dinner (ppx)
15 for crcl<50
Tx: 15 bid x 21 d then 20 qd
Dabigatran dosing
150 bid for both ppx and tx
Ppx: Dose reduce for crcl< 30 (75 bid)
Tx: CI crcl<30 (like Xarelto)
2c9 imhibitors
Metro/macrolides
Amiodarone/azoles
TMP/SMX, tamoxifen
Natural products increase bleed risk
Ginger, ginkgo, garlic, ginseng, glucosamine
Dong quai, vit E, willow tree bark, wintergreen oil, fish oil
Protamine dosing
1 mg: 100 unit hep given in last 3h
(1, 0.5, 0.25)
1 mg: 100 anti Xa units of dalt
1 mg: 1 mg enoxaparin in last 8 hrs (0.5/1 if >8 h to <12h)
Preferred AC in cancer
LMWH
G6PD deficiency drugs
Chloroquine, primaquine, dapsone, BACTRIM/nitrofurantoin, methylene blue,
Probenecid, rasburicase
ABX to avoid if G6PD deficiency
Bactrim, nitrofurantoin
Missed glp-1 dose
Trulicity - not if within 72h of next
Ozempic- skip if >5 d since dose was due
Tricky diabetic meds
Meglitinides: secretagogues- repaglinide (prandin) and nateglinide (starlix)
A-glucosidase inhibitor: miglitol (glyset), acarbose (precose)
Amylin analog: pramlintide (symlin)
Which insulins are cloudy?
NPH, and mixed (protamine)
*when mixing remember clear before cloudy
Concentrated insulins
Humalog 200/ml
Humulin R 500/ml
Tresiba 200/ml
Toujeo 300/ml (only comes like this)
Insulin conversion exceptions
- NPH to basal (80%)
2. Toujeo to lantus or basaglar (80%)
Insulin BUDs
Mostly 28 days
Toujeo/levemir 42
Tresiba/ ozempic 56
Which meds have risk of bladder cancer?
Pioglitazone and dapagliflozin
Thiazidenediones risk
Hepatotoxicity
Also with alogliptan
Counseling point for protease inhibitors
Take with food (except zepatier and fosamprenavir oral susp)
“Previr “
Genetic test for abacavir
HLA-B5701
HIV drug to avoid in pregnancy
Dolutegravir (Tivicay)
Depression drug interaction on exam
Look for St. John’s wort and transplant or birth control
Depression in pregnancy
No paxil
SSRI- ok but still has risks
Depression breastfeeding
SSRI or TCA- but no doxepin
Preferred SSRI if cardiac risk
Sertraline
Unique SSRI adrs
Siadh, hyponatremia, bleeding
Converting antidepressants to or from maoi
2 week washout
Except from Prozac (5 wks)
Tamoxifen antidepressant
Tam is prodrug and needs 2D6
Use venlafaxine
Why use bupropion?
Wt loss, smoking, no sexual adrs
Tyramine rich foods
Aged cheese, beer, pickled stuff, yeast extract, air dried meats, sauerkraut, soy sauce, fava beans, some red wine
Aged, fermented, pickled, smoked
NT issued with PD, schizo, and Alzheimer’s
PD: not enough DA/too much Ach
Schizo: too much DA
Alzheimer’s: not enough Ach
Olz + bzd
Interaction: orthostasis
Typical vs atypical antipsychotics
Typical: more eps, less metabolic
Atypical: less eps, more metabolic
Lowest risk eps
Seroquel
Best for PD
*also clozapine
Highest risk eps
Risperidone, paliperidone, lurasidone
Highest metabolic adr
Clozapine, OLZ, quetiapine
Lowest metabolic risk
FGA, abilify, ziprazidone, lurasidone, asenapine
Antipsych worst QTC
Thioridazine, haldol, ziprasidone
Antipsych risk of CVA
Risperidone
Antipsych risk of increase prolactin
Risperidone, paliperidone
Clozapine
3rd line *start 12.5 mg QD-BID **dangerous constipation*** Siallorhea High metabolic Low eps ANC >1500 to start- check weekly x 6 months, q2wks x 6 months, then monthly D/c if ANC<1000 -neutropenia and agranulocytosis - myocarditis and cardiomyopathy -seizures
Bipolar depression
Lamotrigine
Bipolar mania
Equetro (CMZ) or valproate
Bipolar mania or bipolar depression
Lithium
Bipolar in pregnancy
Lamotrigine
Or lurasidone ir bipolar depression
Lithium level
0.6-1.2 meq/L
Hand tremor, nausea, confusion, diarrhea if high
Lithium
Hypothyroid!!, teratogenic!!- no pregnancy!!, tremor, GI ADRs, hypercalcemia!, 100% renal cleared, no cyp interactions, low sodium=high lithium (ACE decrease salt and increase lithium
Serotonergic
Don’t use with nsaids (increase lithium)
Dehydration
Valproate + lamotrigine
Valproate inhibits metabolism- start lamictal at lower dose (blue box) 25 mg QOD
When to use meglitinides
Alternative to SFU for elderly or renal dysfunction
Which insulin is preferred in pregnancy
Regular
Humulin R, novolin R
Which insulins are cloudy?
NPH, lente, mixes
Is a medguide required for stimulants?
Yes
Separation of stimulants from MAOI
2 weeks (same as SSRI except Prozac)
Stimulant warnings
Mania- caution w/ psych hx
Seizures
Seratonin syndrome
Anticholinergic
Daytrana
Methylphenidate patch
Hips- 2 hrs before desired effect
Remove after 9 hrs
Daily
Straterra separation for maoi
14 days
Straterra warnings
Suicide, hepatotoxicity
Don’t open capsule
Medguide
Levothyroxine unique ADR
Anxiety
St John’s wort warnings
Photosensitivity, serotonergic
Inducer
Hepatotoxic herbals
Kava, valerian, black cohosh
Anxiety SSRI dosing
Half dose for depression
How long until buspar works?
2-4 wks
Is buspirone serotonergic ?
Yes
Which BZDs are safer in elderly and liver impairment?
Why?
LOT- Lorax, oxaz, temaz
Inactive metabolites
Which SSRI is most stimulating?
Fluoxetine
Sedating SSRIs
Fluvoxamine
Paroxetine
Falling asleep
Eszopiclone, zolpidem
Ramelteon, zaleplon
Staying asleep
Eszopiclone, zaleplon
Doxepin, suvorexant
Intermezzo and edular formulation
SL zolpidem
Zopimist
Zolpidem spray
Possible severe adr with modafinil or armodafinil
SJS
Preferred antipsychotic in parkinsons
Seroquel
Or clozapine maybe or nuplazid (pimavanserin)
Sinemet separation for maoi
2 weeks
Sinemet adrs
Dark urine,saliva,sweat Hemolysis (positive Coombs) Sexual urges Orthostasis Separate from iron and protein
Dopamine agonist adrs
Hypotension, hallucinations, sleep attacks, movement stuff
Pramipexole (mirapex) starting dose
0.125 TID
Decrease 50% if crcl<50
Ropinerole (requip) staring dose
0.25 mg TID
Apokyn ADRs
Apomorphine
Severe hypotension and N/V, QTc
Test dose in office
No 5ht3 blocker bc worsens Hypotension-give Tigan (trimethobenzamide) 3 days before initial dose
Huge issue with PD and drugs used to treat PD
Orthostasis
Calcitonin indication
Hypercalcemia or osteoporosis or pagets
DonepeZil ADRs
Nausea- take QHS
Insomnia- take in morning if this happens
Bradycardia
Start 5 mg increase to 10 after 4-6 weeks
ODT has less adrs
Acetylcholinesterase ADR
For AD
BRADYCARDIA
nausea, insomnia
Drugs that cause seizures
Bupropion, clozapine, varenacline, carbipenems, lithium, meperidine, tramadol, quinolones, pcns, reglan, acyclovir, cephalosporins, valacyclovir, theophylline
Lamotrigine dosing
Lower dose (blue box): 25 QODvalproate Higher dose (green): inducers, estrogen containing contraceptives: 50 QD
Keppra iv to po
1:1
Epilepsy drug big concerns
Rash, bone loss, suicide, CNS, interactions
Carbamazepine oxcarb, eslicarbazepine
Hyponatremia, rash, enzyme inducer
Topiramate, zonisamide
Weight loss, metabolic acidosis, nephrolithiasis and oligohidrosis
Topiramate ADR
Metabolic acidosis, nephrolithiasis, glaucoma, hyperanmonemia, vision issues, fetal harm, weight loss, concentration
Only antiepileptic that’s an inhibitor
Divalproex
Depakote ADR
Hepatic failure , fetal harm, hyperammonemia (give carnatine), thrombocytopenia, DRESS, weight gain
Range: 50-100
Carbamazepine genetic test
HLA-B 1502
Risk of serious skin reactions
Asian
Carbamazepine
SJS/TEN
Aplastic anemia, agranulocytosis, myelosuppression, hyponatremia (siadh), fetal harm
Range: 4-12
Vimpat (lacosamide) adr
Prolongs PR interval, DRESS
CV
Oxcarbazepine genetic test
HLA-B 1502
SJS/TEN
Asian
Oxcarbamazepine ADRs
SJS/TEN, DRESS, hyponatremia
Oxcarb/carb autoinducer
Carb: autoinducer
Oxcarb: not autoinducer
Phenobarbital ADR
Hypotension if IV, SJS/TEN, respiratory depression, fetal harm
Range: 20-40
Phenytoin max rate
50 mg/min
Hypotension and cardiac arrhythmia
Fosphenytoin max rate
150 PE/ minute
1.5 mg= 1 mg PE
Phenytoin equivalent
1.5 mg fospehny= 1 mg PE
Phenytoin genetic
Avoid in HLA-B 1502
Phenytoin range
10-20 total
1-2.5 free
Phenytoin ADRs
Extravasation (leads to purple glove), DRESS, fetal harm, bradycardia, SJS/TEN, blood dyscarsias, hepatoroxiy, gingival hyperplasia, hair Growth, nystagmus, ataxia, diplopia, respiratory depression
Phenytoin admin reqs
DNE 50 mg/min Filter (if continuous infusion) NS only Do not refrigerate When adjusting dose do by 30-50% at a time
Enteral feeding and phenytoin
Decreases phenytoin absorption so hold feeding 1-2 hrs before and after
Phenytoin PPB
High- can displace other drugs and increase levels
Oral contraceptive drug interactions
Enzyme inducers!!
Corrected phenytoin
Total/(0.2x albumin) +0.1
For albumin <3.5
Free level doesn’t need it
Epilepsy drugs in pregnancy
- AEDs bad! Valproate/ carb worst
- AED decrease BC (use IUD)
- give folate, ca2+, vit d (baby needs)
- AED levels decline in preganancy (increase dose)
- seizure can harm babies
Which AEDs can lack of sweating?
Topiramate, Zonisamide
Which population has greatest risk of lamotrigine rash?
Children
Which epilepsy drugs are best for kids?
Lamotrigine and Keppra because available as ODT and liquid/chewable
Supplementation needed if taking seizure med
Vitamin d and calcium
Bone loss
Drugs that cause hypothyroidism
I TALc
Interferon, TKI, amiodarone,
Lithium, carbamazepine,
(Amio and interferon can also cause hyper)
Condition that causes hypothyroidism
Hashimotos
Normal TSH
0.3-3
Levithyroxine administration
With water 60 mins before breakfast or 3 hours after dinner
separate from food
Levithyroxine starting dose
1.6 mcg/kg/day IBW
If CAD 12.5-25
Thyroid dessicated info
NP thyroid or armour thyroid
Not recommended bc inconsistent dose
Dosed in grains
Goiter
From iodine deficiency (hypothyroid)
Levithyroxine iv to po
1:2
Levothyroxine colors
25-orange, 50-white, 75-violet, 88-olive, 100-yellow, 112-rose, 125-brown, 137-turquoise, 150-blue, 175-lilac, 200-pink, 300-green
Orangutans will vomit on you right before they become large proud giants
Cause of hyperthyroidism
Graves dx
Thyroid bone and heart effects
Hyper- osteoporosis and arrhythmia
Thyroid storm
PTU (preferred) + SSKI or lugols 1 hr after PTU + propranolol + dex + aggressive cooling (APAP and cooling blankets) NOT NSAIDS
PTU and methimazole ADRs
DILE, gi-upset, hepatitis, agranulocytosis
Severe liver toxicity from PTU
Hyperthyroid in preganancy
PTU trimester 1
Methimazole trimester 2-3
Iodine
Lugols
SSKI
Temporarily blocks secretion of iodine
Levothyroxine in pregnancy
30-50% increased dose
Who steroid mimics aldosterone?
Fludrocortison
Mineralcorticoid activity- maintains balance of water and electrolytes
-use for addisons and orthostatic hypotension
Glucocorticoid difference from mineralcorticoid
Gluco better for anti inflammatory
Addisons
Not enough steroids- can occurs if steroids stopped suddenly (hpa suppression)
Steroid immune suppression dose
> 2 mg/kg/day or >20 prednisone equivalent for >2 weeks
- no live vaccines
- taper! 10-20%/day
Immunosupression risks
- reactivation of TB/hep B/C
- live vaccines
- lymphomas and skin cancers
- infections
Lab tests for RA
RF, ACPA
MTX dosing
RA- weekly
Cancer- daily
MTX toxicity
Hepatotoxicity, myelosuppression, no pregnancy!, mucositis/bleeding
Pneumocystits pneumonia
DMARD (non-biologic)
Hydroxychloroquine ADR
Irreversible retinopathy
Caution G6PD deficiency
-less liver risk that MTX
*non-biological DMARD
SulfasalaZine ADRs
- Sulfa allergy
- salycilate allergy
- liver, rash, G6PD deficiency, blood dyscrasias
- yellow/orange skin and urine
- non- biological DMARD
DMARD rule
Never use two biological together
Arava toxicity
Leflunamide
- fetal/embryo- 2 years after to get pregnant or accelerated via cholestyramine or activated charcoals x11 days
- Hepatotoxicity
Xeljanz risk
Tofacitinib
PE, malignancy (lymphomas )
Non-bio DMARD
*DONT USE WITH BIOLOGIC
Olumiant risks
Barcitinib
Non biologic DMARD
PE
Don’t use with biologic
MTX with etoh?
NO! Liver toxicity
MTX renal
Yes- still a consideration
MTX drug interaction
NSAIDs
Bleeding
TNF biologic DMARD warnings
Infections (TB/HEP), malignancy
HF, lupus like, hepatotoxicity
No live vaccine- no two biologics
Eteracept and adalimumab storage
14 days at room temp
Biologic admin
Allow to warm first!
Don’t shake
Non TNF DMARD toxicity
Basically the same as TNF
DILE drugs
Methimazole, PTU, methyldopa, minocycline, procainamide, hydralazine, anti-TNF agents, terbinafine, isoniazid, quinidine
My pretty malar marking probably has a transIent quality
Benlysta
Belimumab
Biologic DMARD
For SLE
Drugs for SLE
Hydroxychloroquine, cyclophosphamide, azathioprine, mycophenolate, cyclosporine
Preferred MS drug in pregnancy
Glatiramer acetate
Nope…actually glatiramer…
Copaxone
Interferon beta toxicity
Psychiatric (depression/suicide) Injection site necrosis Myelosuppression LFTs Hyper/hypo thyroid Flu like symptoms Infections
Reynauds treatments
Nifedipine or other non-DHP CCB
Drugs that worsen reynauds
BB, bleomycin, cisplatin , sympathomimetics
Avoid in celiac dx
Gluten is found in wheat, barely and rye
*starch may be wheat
Autoimmune disorders
Myasthenia gravis
MS , RA, SLE, reynauds, celiac dx, sjogrens
PAH Pulmonary arterial pressure
PAP >25
Warfarin goal on PAH
1.5-2.5
CCB for PAH
LA nifedipine, dilt, and amlodipine
*not verapamil (‘ore pronounce negative iontropic effects )
Drugs that cause pulmonary fibrosis
Amiodarone, bleomycin, dronedarone, methotrexate,
nitrofurantoin, sulfasalzine
When to avoid nicotine inhaler or nasal spray
Asthma/COPD/ respiratory dx
Nicotine patch dosing
> 10 cigs: 21 mcg
-21x6 wk, 14x2, 7x2
<10 cigs: 14 mcg
-14x6 wk, 7x2
Nicotine gum/lozenge dosing
<30 mins: 4 mg
>30 mins: 2 mg
Max gun: 24 pc
Max Loz: 20 pc
Nicotine patch MRI
Remove!
Zyban details
- start 1 wk before quit date
- serotonergic
- max 300 mg
- use up to 6 months
Chantix details
- start one week before quit date
- day1-3: 0.5 mg qd
- days 4-7: 0.5 mg BID
- day 8 on: 1 mg BID
- nausea, seizures, insomnia, dreams, headache
- only med not combined with NRT
- take with food
- use for 12 wks, can use for another 12 if needed
When not to treat smoking cessation with meds
Pregnancy, adolescence, light smokers (<10 cigs/day)
Nicotine patch details
Never cut
Wear for 24 hrs unless bad dreams
Nicotine lozenge detail
No acidic beverages
Indication that asthma is poorly controlled
Rescue inhaler >2 days per week
General asthma algorithm
Saba AND prn LD ICS/formoterol——> daily ICS—->LD ICS+laba——> MD ICS+laba—->HD ICS+laba
Basically ICS + laba and increase Add laba before increasing to HD ICS
Can you use laba alone?
Not for asthma
HFA
MDI
Respimat
MDI
Diskus
DPI
Ellipta
DPI
Pressair
DPI
Handihaler
DPI
Capsule for inhalation
Neohaler
DPI
Capsule for inhalation
Respiclick
DPI
Flexhaler
DPI
MDI details
- slow/deep breath
- Shake (except: alcesco, respimats, and qvar redihaler
- can use spacer
DPI details
- quick/forceful breath
- no spacers
- do not shake
- no priming needed
Theophylline range
5-15 mcg/mL
Aminophylline to theophylline
Multiply by 0.8 (ATM)
Drugs that can increase theophylline
Cipro, zafirlukast, zileuton
Asthma pregnancy
SABA
Budesonide
How long should proair last
12 months
How long should ventolin last
15 weeks
How long to wait in between inhaler inhalation’s
60 seconds
Order to use beta-2 agonist and ICS
Beta-2 (or laba/lama) the ICS
What can you mix montelukast with?
Formula or breast milk, applesauce, carrots, rice, ice cream
Take within 15 mins!
Which is reversible asthma or copd?
Asthma
Copd diagnosis
Post bronchodilator fev1/fvc<0.7
COPD scoring
CD
AB
Left: cat<10 mcrc 0-1
Right: cat>10 mcrc 2+
Down: 0-1 exacerbations
Up: 2 or 1 hospitalization
Only way to slow COPD progression
Stop smoking- drugs just help symptoms and reduce hospitalizations
First line tx copd
Bronchodilators
Copd treatment
A: sama or saba B: lama or laba C: lama D: lama or lama+laba *ics if eos>300
When to use ABX fir copd
Increase sputum, purulence, dyspnea,
Inc purulence + one other symptom
mech ventilation
Respimat directions
Twist open press (TOP)
Steroid equivalency
Beta: 0.6 /dex: 0.75 Methlypred/triamcin: 4 Pred/pred: 5 Hydrocortisone: 20 Cortisone: 25
Hep c meds not taken with food
Zepatier (no regard)
Fosamprenavir oral susp
Hep c drugs avoid acid suppressive therapy
HEV: harvoni, epclusa, vosevi
Pangenotypic hep c drugs
Mavyret and epclusa
Hep c salvage
Vosevi and mavyret
Hep c approved for 8 weeks
Mavyret
Hep c/ hiv co infection
MEH: mavyret, epclusa, harvoni
Hep c no mono therapy
Sofosbuvir and daclatasvir
Typical hep c treatment duration
12 weeks
Hemoglobin reqs for epogen
Start if <10
Stop if >11
Drugs that you wouldn’t think of that increase k+
Cangliflozin, drosperinone, bactrim, cyclosporin, everolimus, tacrolimus
Heparin, glycopyrrolate, nsaids, pentamidine
Does unasyn cover pseudomonas ?
No
PCNs that cover anaerobes
Beta lactamse inhibitor
Augmenting, unasyn, zosyn
Antistaph pcns
Dicloxicillin, nafcillin, oxacillin
No g (-), enterococcus, or anerobic coverage
No renal adjustment!
Why is PO ampicillin rarely used?
Poor BA- use amoxicillin for PO
Tx for strep throat (pharyngitis) and mild skin infection
Pen vk
First line tx otits media
Amoxicillin 80-90 mg/kg/d
*90 mg/kg/d (augmentin)
Infective endocarditis ppx
Amoxicillin 2g x1 30-60 min before
Which pcns don’t require renal adjustment ?
Naficllin, oxacillin, dicloxacillin
Syphilis tx
Bicillin LA (pen g benzathine)
No iv!!!
Drugs for enterococcus
PCNs not cephalosporins
Cephalosporins for Anarobes
Cefoxiten, cefotetan
Cephalosporins for MDR pseudomonas
Ceftaz/avibactam (avycaz)
Ceftolozane/tazobactam (zerbaxa)
Cefotetan weird ADR
Bleeding, disulfiram like rx
Due to side chain
Cephalexin common uses
Street throat, mssa skin infxn
Cefuroxime common use
Otitis media, CAP, sinus infxn
Cefdinir common uses
CAP, sinus infxn
Cefazolin common use
Surgical ppx
Cefotetan/cefoxitin common use
Anerobes, surgical ppx for colerectal procedure
Ceftriaxone/ cefotaxime common use
CAP, meningitis, SBP
Ertapenem does not cover
Pseudomonas, enterococcus, acintobacter
Carbapenem coverage
Yes: ESBL, pseudomonas (except invanz), anerobes
No: atypicals, MRSA, VRE, cdif, stenotrophomonas
Aztreonam coverage
Pseudomonas
No g (+) or anerobes
Benefit of extended interval dosing for AMGs
Cost and less nephrotoxicity
Not more effective
Gentamicin/tobra dosing
Traditional: 1-2.5 mg/kg/dose q8
Extended interval: 4-7 mg/kg/dose
Genta/tobra and amikacin peak and trough
Gent/tobra
- peak: 5-10
- trough: <2
Amikacin
- peak: 20-30
- trough: <5
Which FQ cover pseudomonas
Cipro and levo
Which FQ can NOT be used for uti?
Moxifloxacin
Which FQ covers mrsa ?
Delafloxacin
Cipro weird interaction
Don’t use with tizanidine
FQ highest QTc risk
Moxifloxacin
Cipro oral suspension rule
No NG tube!
Which is the only FQ not renally adjusted?
Moxifloxacin
Levofloxacin abd moxifloxacin iv to po ratio
1:1
Macrolide with most severe qt prolongation
Erythromycin
Are macrolides hepatotoxic?
Yes
Which macrolide required renal dose adjustment
Clarithromycin
Crcl<30
Which macrolide has fewer drug interactions ?
Azithromycin
Doxycycline and minocycline iv:po
1:1
Doxycycline renal adjustment
No
Yes for tetra and mino
What does bactrim not cover?
Pseudomonas, atypicals, anearobes, enterococcus
Bactrim strengths
Ss: 400/80
DS: 800/160
Bactrim uti dose
1 DS BID x 3 d
Crcl to decrease vanc dosing interval to q24
<50
MIC not to use vanc
> 2
1:1 ABX
Bactrim, metronidazole, levo/moxi, doxy/mino, linezolid, fluconazole,
isavu/posaconazole /vori
Televancin risks
Pregnancy, nephrotoxic, incompatible with heparin, red man, false increase ptt/ inr, QTc
Oritavancin and dalbavancin risks
No heparin with 5 d (false elevation in ptt)
Red man
Televancin increase QTc
*note: can use single dose regimen
Daptomycin tox
Myopathy/rhabdo
False increase ptt/inr
Increase cpk
No D5W
No pna
4mg/kg/d
Dose adjust for renal
Linezolid tox
Seratonin syndrome, myelosuppression, thrombocytopenia, hypoglycemia, , HTN, optic neuropathy
Does linezolid required renal adjustment?
No
Synercid details
Arthralgia/myalgias, infusion rxn, hyperbilirubinemia,
D5W only
Central line only (phlebitis)
Tigecycline details
No bloodstream infxns: lipophi
Risk of death
Should be yellow/orange
Colistimethate and polymyxin B tox
Nephro and neuro
Chloramphenicol tox
Gray syndrome
Clindamycin coverage
Anaerobes and g(+)
MRSA (positive D test means do NOT use!!)
*no dose adjustment for renal
Abx susp requiring refrigerator
Pen vk, ampicillin, augmentin
*amoxicillin tastes better
ABX don’t refrigerate
Cefdinir, azithromycin/clarith
Doxy, FQ, clinda, linezolid, bactrim, acyclovir, fluc/Posa/voriconazole, nystatin
Metronidazole, moxifloxacin
Weird nitrofurantoin adr
Pulmonary toxicity
When to start ppx ABX for surgery
Cefazolin/cefuroxime: 60 mins prior
FQ/ vanc: 120 min before
Meningitis tx
Ceftriaxone/cefotaxime + vanc
Add ampicillin if <1 mo, >50, immunocomprimised!!!!
No ceftriaxone or vanc in <1 mo
- Ampicillin is for listeria
- give steroid prior to or with first dose of ABX
Acute otitis media tx
Mild- 2-3 d observation
Amoxicillin 80-90 mg/kg/d (bid)
Augmentin 90 mg/kg/d (bid)
Cephalosporin in non-severe PCN allergy (2nd Ir 3rd gen)
Strept throat tx
PCN or amo
Sinusitis tx
Augmentin
> 10 d of symptoms
Copd exacerbation tx
Augmentin, azithromycin, doxycycline
Or FQ! I’d suspect pseudomonas
5-7 d
-ventilated, purulence sputum, dyspnea, increased sputum
CAP (outpatient)
Macrolide or doxycycline
-add beta Lactam or use mono therapy FQ (MGL) if immunocomproised, comirbidities, or recent ABX use (90 d)
5 days
*never beta lactam alone
Inpatient CAP
Never monotherapy with macrolide or doxy
Use FQ or add beta lactam
HAP/ VAP
7 d
> 48 h hospitalization or vent
Think MRSA and Pseudomonas
Double cover pseudomonas if risk for MDR (recent ABX, etc)
Follow up for TB skin test
48-72 hr
TB latent tx
INH x 9 month (HIV, pregnant, child) OR
Rifampin x 4 month OR
INH + rifapentine x 12 wk
Active TB tx
RIPE x 2 months
Then 2 drugs x 4 months (RI)
Don’t do 3x weekly dosing for pts w/ HIV
Latent:
-R for 4 months
-RI for 3 months
Rifampin toxicity
Hemolysis, interactions (use rifabutin), orange discoloration, LFTs, flu-like syndrome
*CI with PI
Isoniazid tox
INH
Peripheral neuropathy (use pyridoxine B6), fatal hepatitis!!!, DILE, hemolysis, inhibitor
Pyrazinamide tox
LFT, hyperuricemia
Ethambutol tox
Optic neuritis
-confusion and hallucinations!!
TB drugs empty stomach and hemolysis
RI: rifampin, INH
TB drugs: increase interval for renal impairment
PE: pyrizinamide, ethambutol
IE tx
Beta lactam +/- gent
Use gent and rifampin if prosthetic valve
If enterococcus NO cephalosporin
Vanc if MRSA or beta lactam allergy
IV x 4-6 weeks
Dental PPX PCN allergy
Clinda 600 or azithromycin 500
SBP tx
Ceftriaxone x 5-7d
Cipro or bactrim for ppx
Intraabdominal infxn
Cover anaerobes
4-7 d
Impetigo tx
Cephalexin 250 qid
Mupirocin
SSTI tx
- Cephalexin
- clinda if beta lactam allergy
- bactrim or doxy for MRSA, purulence, or abscess
For severe: iv MRSA ABX
Animal bite ABX
Unasyn or augmentin (covers pasturella and anerobes
Diabetic foot infection coverage
Mild: beta lactams
Anerobes- mod-sev
PSA and MRSA: if severe infection
MRSA, pseudomonas if at risk
Does zosyn cover anerobes ?
Yes
Pylonephritis tx
Cipro 500 bid x 7 d
Levo 750 QD x 5 d
Phenazopyridine
2 days!
With food or water!
UTI pregnancy
Beta lactam: amoxicillin, augmentin, oral cephalosporin
Nitrofurantoin and bactrim pregnancy
Ok in 1st trimester
Doxycycline pregnancy
No!!!
Direct acting antiviral (Hep C) tox
Reactivation of hep B
LFTs
Generally well tolerated
Travelers diarrhea
Azithromycin 1g x1 or 500 mg x 3
FQ or rifaximin ok if no dysentery
Loperamide if no dysentery or fever
Cdif tx
Vanc 125 qid x 10 d
Fdx 200 bid x 10 d (preferred)
Met 500 po TID x 10 d (not preferred)
No anti diarrheals
Syphilis tx
Bicillin LA 2.4 mil units IM x 1
-weekly x 3 if latent
-desensitize if pregnant!
Doxy (unless pregnancy) 100 bid x 14 d
Gonorrhea tx
Ceftriaxone 250 IM x 1 + (azithromycin OR doxycycline ) no monotherapy!
Chalmydia tx
Azithromycin 1 g x 1
Or doxy 100 bid x 7 (no pregnancy )
Bacterial vaginosis tx
Metro 500 bid x7 d or topical x5 d
Trichinoniasis tx
Metro 2 g po x 1
Must be PO!
Ok I’m preganancy! Must treat!
Genital warts tx
Imiquimod cream
Vaccinate with HPV to prevent
Rocky Mountain spotted fever
Doxy 100 bid x5-7 d
*even in kids!!!
When is the only time you can use doxy in kids?
Rocky Mountain
Lyme tx
Doxy 100 bid x 10-21 d
Alt: amoxicillin
Ribaverin v rifampin tox
Both: hemolysis
Ribaverin: no preganancy!
Rifampin: LFTs, interactions, orange, flu-like syndrome
*safe in preganancy
TB drugs (RIPE) in pregnancy
Safe
UFH VTE tx
Bolus: 80 u/kg
Infusion: 18 u/kg/hr
UFH stroke tx
Bolus: 60 u/kg
Infusion: 12 u/kg/hr
LMWH tx crcl<30
1 mg/kg Q24
Amophotericin B dose
0.1-1.5 mg/kg/day
Liposomal amphoterecin
Ambisome, amblicet
Less nephrotoxic, less infusion
rxn
Dose: 5
*filter
Amphoterecin tox
Nephrotoxic (give NS), infusion reaction (premedication APAP/Benadryl/hydrocortisone for conventional )
Thrombophlebitis (deoxycholate): dilute and slow infusion, add heparin, and central line!
Cardiopulmonary arrest if dose >1.5 mg/kg/d for conventional!
Rigors
-decrease K+ and mg+ (supplement)
Flucytosin indication and tox
- cryptococcal meningitis
- with ampho- NEVER ALONE!
- follow with fluconazole for consolidation phase
- causes myelosuppression
Azole toxicity
- hypoK+
- liver tox
- Qt (except isavu)
- 3a4 inhibition!!
Only azole that needs renal adjustment
Fluconazole
so this is the only one that can be used for UTI
Also voriconazole due to additive
Drug of choice for aspergillus
Voriconazole
*can also use posa and isavu
Itraconazole tox
-heart!
Qt, liver, low k, 3A4
Which azoles can penetrate CNS and treat meningitis?
Fluconazole and voriconazole
Voriconazole
Visual changes, phototoxic
- low k, liver, qt, 3A4
- good for aspergillus, c gal rats and c krusei
Posaconazole
Full meal
Suspension and tab are no equivalent
Which azole requires a filter ?
Isavuconasonium
Which azoles are separated from antacids ?
Itraconazole and ketoconazole, posaconazole suspension
*could give with diet cola
Micafungin and caspofungin
Echinocandins
- histamine mediated symptoms
- NO renal adjustment
- QD and IV only
- only for very resistant infxns
- good for glabrate or krusei and aspergillus
When to start neurominidase inhibitors (tamiflu and zanamivir)
Within 48 h of illness
Tamiflu dosing
Tx: 75 bid x 5 d
Ppx: 75 qd x 10 d
*adjust crcl<60
- neuropsychiatric ADRs
Varivax vs shingles
Kids take varivax (chickenpox) adults take shingrix
Acyclovir info
- renal adjust (also for valacyclovir and famciclovir )
- dose with IBW!!!
- available Iv for hsv encephalitis
Zovirax cream and abreva dosing
5 times per day
-Zovirax for 4 days
Hsv chronic suppression
Acyclovir 400 Bid
For hsv 2 can use valacyclovir or famciclovir as well
Hsv 1 tx
Valacyclovir 2 g x 1
Acyclovir: ~200-400 bid-tid x 5d
-or can be 5x daily
Hsv 2 tx
Acyclovir is the same as hsv1
Val: 1 g bid
Or famciclovir
Shingles tx
Acyclovir 800 5x for 7d
Val: 1 g tid x 7 d
Fam: 500 tid x 7 d
CMV tx
Valcyte, cytovene
Foscarnet or Cidofovir for refractory
*no primary ppx, secondary ppx can be stopped if cd4>100 x3-6 months
Ganciclovir and valcyte tox
Myelosuppression
-valcyte: eye issues
Cidofovir and foscarnet tox
Renal!
PCP ppx and tx
Ppx (CD4<200): bactrim DS daily
-or D.P.L, atovaquone
*can stop if >200 x3 months
Tx: bactrim x21 d + steroid
Toxoplasmosis tx and ppx
Ppx (CD4<100 and seripositive): bactrim
- or D.P.L, or atovaquone
*can stop if >100 or >200 (secondary ppx) x3-6 months (6 for secondary)
Tx: pyrithin, Lueco, sulfadia
-or bactrim, or atovaquone, or clinda
MAC tx and ppx
Ppx (cd4<50 AND not on ART): azithromycin 1200 weekly
**can stop secondary ppx after 12 months therapy and cd4>100 x6 months
Tx: (clarithro or azithro) + ethambutol x 12 months
Hormone replacement : estrogen alone v estrogen + progesterone
Alone: no uterus
Both: women with uterus
*risk for endometrial CA
Vivelle dot placement and timing
Twice weekly
Lower abdomen below waist
NOT breast
Xulane patch frequency
Weekly
E+P
First line tx of chronic allergic rhinitis
Intranasal steroids
What do oral antihistamines not help with?
Nasal congestion
Preferred antihistamines in pregnancy
Loratidine and Cetirizine
Less sedating antihistamines
Loratadine and fexofenadine
Zinc day limit
5-7 d max
Possibly effective for reduction in cold duration
Vitamin C ADR
Kidney stones
OTC products to separate from MAOI
DM, pseudophed, phenylephrine
DM side effects
Serotonergic , NMDA blocker at higher doses
Codeine CI
Children <12
Benzonotate max dose
600/ d
Diphenhydramine unique effect
Cough suppression
Cough and cold in children
Avoid in less than 6 y
Also avoid menthol in under 2 y
PE abbreviation
Phenyleprhine
AC abbreviation
Codeine
Ibuprofen strengths
Infant drops (50mg/ 1.25mL)
Children’s (100 mg/5mL)
APAP strengths
Infants AND children’s are both 160 mg/ 5mL
Children APAP dosing
10-15 mg/kg /dose q4-6h
*max 5 doses per day!
Ibuprofen children’s dosing
5-10 mg/kg/dose Q6-8h
*max 40 mg/kg/d
Eye and ear sigs
A- ear O- eye U-both D- right S- left
How many drops in an mL
20
1 drop= 0.05 ml
What can not be administered in rye with contact lenses
Eye ointments
Drugs that increase IOP
Anticholinergics, antihistamines, steroids (pred-forte), topiramate
Prostaglandin analog ADR
Iris darkening (brown) and eyelash thickening
Avoid in light eyed people
Most effective eye drop for decreasing IOP
PG analog
Note: use BB if only one eye
Which eye drops require removal on contact lenses?
PG analogs and others with BAK
Wait 15 mins to reinsert!
Benzalkonium chloride absorbs and discolored them ( not in travatan z or xelpros )
When are PG analogs given
Bedtime
Blurred vision
PG analog frequency
Once per day
Timeframe to wait between eye drop admin
Same med: 5 min
Different med: 5-10 min
Only selective BB eye drop
Betaxolol (Betoptic)
NSAID eye drop ending
“Fenac “
Or fluribiprofen
Dry eyes eye drops
Systane or refresh are both artificial tears
Red eye tx
Naphazoline
Visine (tetrahydrozoline)
Latisse
Bimataprost
PG analog
Cosmetic
Drugs that can cause eye issues
Hydroxy(chloroquine), amiodarone, ethambutol, linezolid, alpha blockers, digoxin, PDE-5 inh, voriconazole, isotretinoin, vigabatrin,
Debrox administration
Carbamide peroxide
5-10 drops bid x 4d
How to pul ear from ear drops
Up and back for adults
Down and back for kids <3
Drugs that cause discoloration
Entacapone, levodopa, methyldopa
Nitrofurantoin, sulfasalazine, propofol, phenazopyridine, rifampin, anthracycline, methylene blue, mitoxantrone, amiodarone, chloroquine
Retinoids
- Teratogenic
- 4-6 weeks to work
- acne may worsen initially
- photosensitivity!!
- pea sized amount
- bedtime
Alternative acne txs
Spironlactone, BPO, salicylic acid, ABX, BC
BPO
Acne first line
Can bleach clothing
I pledge
- 2 forms BC (NO P.O.P)
- no preganancy 1 month before and after
- fill within 7 d
- 1 month at a time
Drugs that cause hair loss
Chemo, valproate, spironolactone, heparin
Zinc/ vit D deficiency
Onychomycosis
Nail fungal infxn
Topical NOT enough
Oral terbinafine or itraconazole
20% potassium hydroxide (KOH) to diagnose
When to repeat lice treatment with permethrin or piperonyl butoxide
Day 9
Steroid vehicle potency
Ointment >cream>lotion>solution> gel>spray
Topical steroid potency
Clobetasol> fluocinonide >mometasone>triamcinolone> hydrocortisone
Who can not receive live vaccines ?
Pregnant, immunocompromised, < 12 months
PPD and live vaccine
- Give on same day
- PPD 4 weeks after vac
- Vac after PPD results
When are vaccines started in children?
Live: after 12 months
Inactivated: 2 months- except hep B which is given at birth
Live vaccine separation time
Give on same day- OR separate by 4 weeks
Can you shorten or extend vaccine intervals
You can extend (no need to restart series) but not shorten
Live vaccine separation from IVIG
Vac -wait 2 weeks- IVIG
IVIG - wait 3 months - vac
Loperamide dose
Max rx: 16 mg/d Max otc: 8 mg/d Chemo: 24 mg/d Up to 2 days -don’t use if dysentery!
Qvar
MDI
Don’t shake
Finasteride dose
Baldness: 1 mg QD
BPH: 5 mg QD
Which contraceptive method has delay in return to fertility
Medroxyprogesterone injection
When are progestin only pills preferred?
Breastfeeding (Estrogen decreases milk)
Migraine with aura (estrogens can cause stoke)
Window for progestin only pill
3 hours
How often is depo provera given
Q 3 months
Injectable medroxyprogesterone
Benefits of drosperinone
k+ sparing diuretic, less bloating, less pms, less wt gain, less acne
Yaz, yasmin
Drosperinone is a type of progesterone
Progesterone ADR
Decreases bone mineral density
Give with calcium/vit D
Drosperinone: clotting risk
Estrogen CI
Migraine w/ aura, breast/ovarian/liver CA, CV/DM/HTN, smoker, >35, postpartum
Beware: abd pain, CP, HA, eye problems, swelling of leg
More risk with xulane patch
Drosperinone has clot risk
Adjusting COC
Easily spotting: increase estrogen
Late spotting: increase progesterone
ADR: decrease estrogen or use drosperinone containing
BC choice if heavy menstrual bleeding
Natzia, Mirena (IUD)
BC choice: mood disorder
Monophasic, extended cycle, or drosperinone
BC choice: postpartum
POP- no estrogen!
BC choice: premenstual disphoric d/o
Yaz or antidepressant
BC choice: don’t want to bleed
Extended (91 d) or continuous
Which BC has no interactions?
Injection!
Back up Contraception needed for rifampin
Continue for 6 weeks after d/c rifampin
(Due to induction of birth control)
Technivie or viekira pak plus ethinyl estradiol BC
CI!!! Liver tox!
Back up for BC start
Start today: 7 d
Sunday: 7 d
If within 5 d of START of period: no backup
POP: start anytime- 48h
Late/ missed BC
Combo
-1 missed/<48 h: no backup- double up
-2 missed />48 h: back up x7 d
POP: 3 h need back up
Which EC requires RX
Ella
PCN food
Empty stomach
Doxycycline food
With food (except oracea) Minocycline with food
Tetracycline- empty stomach
Videx (didanosine) interactions
It is like a divalent cation
Synercid renal
No adjustment!
Metronidazole food
With food
Bactrim and nitrofurantoin food
With food
Voriconazole food
No! Empty stomach!
Itraconazole food
Caps: yes! Needs acid
Solution: not necessary
Carvedilol, labetolol, metoprolol- food
With food
HTN meds to avoid in pregnancy
ACE/ARB, diuretics
Women folate/vit d/ca requirements
Child bearing age: 400 mcg
Pregnant: 600 mcg folate
-D: 600 u
Ca2+: 1000 mg
Drugs not to use in pregnancy
Less obvious: quinolones, hormones/BC, raloxifene, ergots, megace, hydroxyurea, lithium, ribaverin, topiramate, paxil, amiodarone/ dronedarone, fluconazole/voriconazole, grisofulvin, lenolidomide, phenytoin, phenobarbital, atenolol, AMG, radioactive iodine,
Obvious: retinoids, statins,
, tetracyclines, warfarin, MTX, misoprostol, nsaids, thalidomide, valproate, CMZ, finasteride/dutasteride, ERAs, leflunamide, methimazole/PTU,RASS,
Pregnancy nausea
Pyridoxine (B6), doxylamine
Ginger
Pregnancy GERD
Calcium carbonate
Pregnancy flatulence
Simethicone
Pregnancy constipation
Fiber: psyllium, calcium polycarbophil
Docusate
Pregnancy: cough, cold, allergy
Chlorpheniramine (DOC), Benadryl,
ICS: budesonide, beclonethasone (B for baby)
No pseudo or oxymetazoline!!!
Pregnancy: pain
APAP
No nsaids or asa!!!
Pregnancy asthma
Budesonide, albuterol
Pregnancy DM
Insulin! Regular!
Sometime Metformin and glyburide
Pregnancy ABX
PCN, amox/amp, cephalosporin, erythromycin/azithromycin
No: clarithromycin, FQ, tetracyclines, fluconazole,
Nitrofurantoin and bactrim maybe in first trimester
Pregnancy VTE
LMWH > UFH
No warfarin, XA and thrombin-I not studied so no
Breastfeeding considerations
- No codeine/tramadol
- no HIV positive
- supplement baby w
- 400 unit vit D
- 1 mg/kg iron months 4-6
- no amohetamines, ergots, amiodarone, lithium, statins, phenobarbital, or metronidazole
Progesterone effect on bones
Decreases BMD
PPI effect on bones
Decreases BMD- increase ph will reduce ca2+ absorption
Steroid effect on bones
Decreases BMD
Calcium tips
- Saturable absorption- divide doses
- citrate better if higher PH (PPI)
- carbonate- take with food
- ADR- Constipatjon
Calcium strengths
Carbonate: 40% elemental
-1 g= 400 mg elemental
Citrate: 21% elemental
-1 g= 210 mg elemental
Bisphosphonates info
- Sit upright x 30 min (bonivia 60 mins)/ full glass of water
- EMPTY STOMACH
- NO DIVALENT CATIONS
- do dental work before
- ADR: hypocalcemia, osteonecrosis or jaw, dyspepsia, esophagitis
- separate 2 h divalent cations
- caution renal
- missed dose: don’t double up, take next day
Estrogen bone effects
Increased BMD
Weird estrogen ADR
Dementia
Menopause natural products
Black cohosh, evening primrose, red clover, soy
Paroxetine interactions
Warfarin- increased bleed risk
Tamoxifen- reduced efficacy
Meds that can lower testosterone
Methadone, cimetidine, spironolactone, chemo
Testosterone ADRs
CV/clotting, hepatotoxicity, baldness, acne, gynecomastia
- worsens BPH- don’t give if on finasteride
- secondary exposure to women and children
- remove androderm patch for MRI
- gels are flammable
Is lithium serotonergic?
Yes
Lithium food
Take with meals!
Cochcine major ADR
Diarrhea, N/V
*note: medguide needed
Which type of vit D is active?
Calcitriol
D3
Medroxyprogesterone pregnancy
Category X
Meds that cause ED
SSRI/SNRI, beta blockers, clonidine, typical AS, risperidone/paliperidone, finasteride, nicotine, chronic opioids (methadone)
Natural products for ED
Yohimbe, l-arginine, panax ginseng
What else is tadalafil used for?
BPH, PAH
ED dosing
Sildenafil: 50 mg Vardenafil (Levitra): 10 mg Cialis: 10 mg Avanafil (stendra): 100 mg *50% if elderly, alpha blocker, cyp3a4 inhibitor, renal or liver dx
PDE info
Impaired color, hearing loss, vision loss, hypotension, headache, dyspepsia, flushing
- sildenafil and vardenafil decreased efficacy with high fat/meal
- no etoh
When to take PDEs before sexual activity
Avanafil: 15 min
Tadalafil: 30
Sildenafil/vardenafil: 60 min
Which natural products are used for BPH (not recommended)
Saw palmetto, pygeum
Natural products for prostate CA prevention
Lycopene
When should 5-alpha reductase inhibitor NOT be used
BPH w/o prostate enlargement
*they reduce the size of prostate
Meds to worry about with cataract surgery
Alpha blockers
Floppy iris syndrome
Tadalafil weird ADR
Back pain
When to take tamsulosin
30 mins after a meal
When to take tamsulosin
30 mins after a meal
Which drug class worsens dementia?
Anticholinergics (obviously)
Reducing try mouth from anticholinergic for OAB
Oxybutynin Patch or gel or ER
Or mirabegron
Nocturia tx
Desmopressin
ADR: hyponatremia! Retains water!
Caution: fluid retention
Minimum MME for fentanyl patch
60 mme x 7 d
After applying fentanyl patch…
Decrease other opioids by 50% x 12 h before stopping
Takes 8-16 h for effect
Fentanyl and other opioid drug interactions
What for 3A4 inhibitors
Opioid 3A4 substrates
Fentanyl, methadone, hydrocodone, oxycodone
Natural products for migraine
Butterbur, feverfew, magnesium, riboflavin
Triptan concerns
CV, BP, serotonin , paresthesias
CI in pregnancy!!!
Long acting triptans
Frovatriptan, naratriptan
Triptan drug interaction
MAOI
Sumatriptan, rizatriptan, zolmitriptan
When not to use ODT triptans
Phenylketonuria
Rizatriptan/zolmitriptan MLT
Common joint effected by gout
Metatarsophalangeal (big toe)
Drugs that increase uric acid
Aspirin, diuretics, niacin, pyrazinamide
Pancreatic enzymes, calcineurin inhibitors,
Goal uric acid level
<6
Don’t treat unless a gout attack has occurred
Do you stop or continue Uric acid lowering therapy during gout attack
Continue
Colchicine tx dose
1.2 then 0.6 1 hour later
Max: 1.8/ hr; 2.4/ day
Don’t repeat sooner than 3 days
Colchicine ppx dose
0.6 QD or bid
Cochicine info
- Don’t use with cyp3a4 or pg-protein inhibitors!!!!
- N/D, myelosuppression, myopathy, neuropathy
- *wait 12 h after tx before resuming ppx**
PDA tx in fetus
Indomethacin, ibuprofen
Big colchicine interaction
Pg-protein or 3A4 inhibitors
How to start xanthine oxidase inhibitor
With colchicine or nsaids
can precipitate attack
Allopurinol allele
HLA-B*5801
Azathioprine/mercaptopurine + XOI
Don’t use febuxostat or allopurinol with azathioprine (increases conc of active metabolite Mercaptopurine)
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
How often is clonidine patch changed?
Weekly
Drugs that worsen gerd
Aspirin/NSAIds, iron, bisphosphonates, dabigatran, estrogens, fish oil, steroids, tetracyclines, nicotine
How long should initial trial of PPI be?
2 weeks
H2 blockers ADR
Confusion, B12 deficiency, renally adjust <50 (famitidine, ranitidine, nizatidine)
30-60 mins before eating
PPI meal timing
Before breakfast ESO, Omep, lans
W/o regard: dexilant, pantop, raber
PPI ADR
Cdif, B12 deficiency, decreased BMD
30-60 min before breakfast
No omep/ esomeprazole with clopidogrel
No crush: open and caps and mix with applesauce (no chewing)
PPI available as injection
Pantoprazole, esomeprazole
H2 blockers available as injection.
Famitidine, ranitidine
OTC PPI
Omeprazole, esomeprazole, lansoprazole
ODT PPI
Lansoprazole, omeprazole
OTC h2 blockers
Cimetidine, ranitidine, famitidine
Metoclopramide MOA
Dopamine antagonist + seratonin blocker in CTZ at higher doses
Drugs for peptic ulcer dx but not GERD
Misoprostol, metoclopramide, sucralfate
When to renally adjust reglan
Crcl<40, decrease by 50% (2.5-5 qid)
Drugs with decreases absorption if taken with antacids
Rilpivirine, atazanavir, ledipasvir, velpatasvir/sofosbuvir (epclusa, harvoni) (HEV), itraconazole m, ketoconazole, posaconazole suspension, cefpodoxime, cefuroxime, iron, mesalamine, atelvia (risendronate ER), TKI,
Drugs that bind antacids
INSTIs, bisphosphonates, isoniazid, mycophenolate, quinolones, soya lol, steroids (budesonide). Tetracyclines, thyroids products
H2 blocker- increased QTc
Famotidine
Bacteria causing peptic ulcers
H. Pylori- spiral shaped gram negative
Eating and ulcer pain
Duodenal (h pylori): worse on empty stomach
Gastric (nsaids): worse with eating
Urea breath test
Tests for h pylori ulcer
D/c PPI, bismuth, and ABX 2 weeks before
H pylori tx
Bismuth, metro, tetracycline, PPI
pylera QID + PPI BID
Alt: clarithromycin + amo + metro + PPI BID
CAM BID + PPI BID
These are both quadruple
Duration of therapy H pylori tx
10-14 d
If triple therapy: 14 d
Safer NSAIDs with risk for GI
Celecoxib, meloxicam, diclofenac, nabumetone, etodolac
Misoprostol issues
Abortifacient, diarrhea, abd pain
*200 mg qid
Sucralfate issues
Constipation, DI (2h before and 4 h after)
1 g QID before meals/bedtime
When to seek medical attention for GERD
Self tx > 14 d or twice weekly
Aluminum: constipation or diarrhea
Constipation
Prevacid solutab CI
Phenylketonuria (contains aspartame)
Drugs that increase lipids
PAST D
Protease inhibitors, atypicals AS, steroids, transplant, diuretics
Estrogens, tamoxifen, bile acid sequestrants, sglt2
Natural products for cholesterol
Red yeast rice
When statin is indicated
ASCVD risk >7.5%, DM, ldl >190, clinical ASCVD
Who gets high intensity statin
ASCVD (stoke/tia, PAD), ldl>190, age 40-75 ldl 70-189 and ASCVD >20%, age 40-75 DM and mx risk factors for ASCVD
Moderate intensity: ASCVD risk 5-19.9%, or age >75
Add on therapy if <50 ldl dec with high intensity or ldl still >70
Lipid lowering drug CI with statin
Gemfibrozil
Statin + colchicine
Interaction: increased risk myopathy
Hydrophilic statins
Pravastatin, rosivastatin
Less interaction and mypothay
Pitavastatin also less DI
Weird 3a4 inhibitors- reduce statin dose
Cyclosporin, nefazodone
*danazole (with simvastatin)
What time is niaspan taken
Bedtime
With low-fat snack
When to start BP med
Stage 2 or stage 1 plus CVD or ASCVD >10%
When to start two BP meds
> 150/90
When to start HTN therapy in pregnancy
> 160/105
Thiazides renal
Not effective below crcl<30 except metolazone
Only IV thiazide
Diuril (chlorthiazide )
Only IV thiazide
Diuril (chlorthiazide )
Safest CCB in HFrEF
Amlodipine, felodipine
BUD of clevidipine and propofol after opening vial
12 h
BUD of clevidipine after opening vial
12 h
Which k+ sparing diuretics better at lowering BP
Aldosterone antagonists (eplerenone and spironolactone)
Non selective BB
Nadolol (corgard), pindolol, prop, timolol
BB Effect in BG
Can increase or decrease
BB Effect in BG
Can increase or decrease
HTN emergency- how fast to decrease BP
Max 25% in 1 h
(>180/120)
If urgency use orals
Does stable angina count as clinical ASCVD
Yes
Tx of stable angina
ABCDE
Antiplatelet/antianginal, BP/BB, cholesterol (statins), DM, exercise
- It’s ASCVD so need statin + ASA
- BB first line
When to use DAPT
SIADH -bare metal stent x 1 mo -drug eluding stent x 6 mo -cabg x 12 mo Stroke: x 21 d
When to avoid BB in angina
Prinzametals (use DHP)
When to call 911 after nitrate
If angina still there after 1st dose
When to call 911 after nitrate
If angina still there after 1st dose
BUD nitro tabs in glass container
6 months after opening
BUD nitro tabs in glass container
6 months after opening
BUD nitro tabs in glass container
6 months after opening
BUD nitro tabs in glass container
6 months after opening
BUD nitro tabs in glass container
6 months after opening
NTG admin
SL- don’t chew or swallow!
Max 3 doses in 15 mins
May feel tingling or burning- not an indication of efficacy
HA- indication if efficacy
Preferred site for topical NTG
Chest
Not below knees or elbows
Ranolazine interaction
Cyp3a4 substrate
QTc
Dabigatran dosing
150 BID
Crcl<30: 75 BID
Converting dig PO to IV
Decrease by 25%
Time for referral diarrhea
2 d
Time for referral: constipation
7 d
Time for referral: constipation
7 d
Time for referral: constipation
7 d
Time for referral: constipation
7 d
Time for referral: GERD
14 d
Time for referral: GERD
14 d
Time for referral: GERD
14 d
Time for referral: GERD
14 d
Sodium phosphates risk
Fluid and electrolyte abnormalities
*don’t use in renal or cardiac dx
Sodium phosphates risk
Fluid and electrolyte abnormalities
*don’t use in renal or cardiac dx
Sodium phosphates risk
Fluid and electrolyte abnormalities
*don’t use in renal or cardiac dx
Laxatives/ antacids dangerous in CKD
Anything with mg if al
Laxative for post MI, post partum, or hemorrhoids
Docusate
What do you avoid with EC bisacodyl
Milk, dairy, antacids- within 1 hr
Laxative interaction
Mineral oil + docusate= increased absorption
Issue with mineral oil
Take with MV- reduced ADEK
Osmoprep boxed warning
Nephropathy
What can you eat day before colonoscopy
Clear liquid diet
No: pulp, red/blue/purple food coloring, milk, alcohol, semi/solid food
Amitiza
Lubiprostone
Constipation (cl channel)
Linzess
Constipation
Guanylate cyclase
Trulance
Plecanatide
Guanylate cyclase
Constipation
Drugs that cause diarrhea
Cochicine, quinidine, misoprostol
Reglan, ABX, chemo, magnesium, roflumilast
Symproic
Naldenedine
PAMORA
Loperamide risks
Torsades, <2 y/o
Don’t exceed 48 h
Lomotil max dose
20 mg/ d
CV
IBS v IBD
IBD more severe and associated with inflammation
chrones and UC
Ulcerative colitis
Superficial, Confined to rectum and colon
*proctotis if just rectum- can use topicals
Chrones
Deep, affects any part of GI tract
Nicotine weird use
Protective in Ulcerative colitis
Nicotine weird use
Protective in Ulcerative colitis
Nicotine weird use
Protective in Ulcerative colitis
Chrones tx
Mild:Oral budesonide, Mod: humira, remicade, cimzia -azathioprine/ mercaptopurine -stelara (ustekinumab) Refractory: vedolizumab, natizumab
Ulcerative colitis tx
Mild: mesalamine Mod: humira, remicade, simponia -azathioprine/mercaptopurine -cyclosporine -tofacitinib (xeljanz) Refractory: vedolizumab
Tx acute flares of UC and chrones
Steroids
Recital steroids indication
Ulcerative colitis only
Ghost tablets
Desvenlafaxine, nisoldipine (sular), adalat, covera, procardia, asacol, delzicol, glumetza/fortamet, invega, concerta, glucotrol XL, oxybutynin XL
Who should not receive promethazine
Children- respiratory depression
What is not effective for motion sickness
Reglan and 5HT-3 antagonists
Scopamaline risks
Increased IOP- no glaucoma (same with Dramamine and meclizine)
Allergy to belladonna
When to apply scopalamine
4 h before needed or night before surgery
Press x 30 seconds
No MRI
RA v MS tx
RA:
- non-bio: DMARD MTX, hydroxychloroquine, sulfasalazine, leflunamide, tofacitinib, baracitinib - TNF and non-TNF bio-DMARD
MS: interferon beta, glatiramer acetate,
-teriflunamide, fingolomid, dinethyl fumarate, simponimod, dalfamfridine, tysabri, alemtuzumab, ocrevus, cladrabine
RA v MS tx
RA:
- non-bio: DMARD MTX, hydroxychloroquine, sulfasalazine, leflunamide, tofacitinib, baracitinib - TNF and non-TNF bio-DMARD
MS: interferon beta, glatiramer acetate,
-teriflunamide, fingolomid, dinethyl fumarate, simponimod, dalfamfridine, tysabri, alemtuzumab, ocrevus, cladrabine
Metformin renal dosing
<30 CI
30-45: don’t start- may continue at half normal dose (500 BID)
PCI only
Abciximab, prasugrel
Brillinta dosing
LD: 180 mg
90 mg BID x12 mo then 60 BID
*don’t use ASA doses >100 mg
*ticagrelor
Plavix LD
Pre-pci after fibrinolytics
600 mg if >24 hrs of fibrinolytic
300 mg if within 24 hrs of fibrinolytic
Just pci
600 mg
When are fibrinolytics indicated?
Only stemi!!! Within 3 hr of symptom onset and 30 mins of arrival!
(60 mins for stroke- or 4.5h from symptom onset)
- if can’t do PCI within 90 mins of arrival or 120 mins of first medical contact
- CI if recent stroke!
When is ACE indicated after ACS
HFrEF <40%, DM, HTN
Aldosterone antagonist (eplerenone/spironolactone renal CI
Men: scr >2.5
Women: scr>2
Lowest CV risk NSAID
Naproxen
When is PPI indicated for antithrombotic therapy?
DAPT + AC
Which drug causes yellow-green halos
Digoxin
Additional affect of dipyridamole
Hypotension (causes HA)
Management of hemorrhagic stoke
- reverse AC
- reduce ICP: mannitol or hypertonic saline
- PPx anticonvulsants only for SAH
- nimodipine to prevent cerebral Vadospasm in SAH
Which CCB is more lipophillic
Nimodipine
Mannitol CI
Severe renal dx
IV bisphosphonates
Ibandronate (bonivia) Q mo
Zolendronate (zometa) yearly
Zolendronate formulations
Reclast: osteoporosis
Zometa: hypercalcemia of malignancy
What decreases lithium ?
Theophylline, caffeine, salt
What increase lithium ?
Ace/arb, thiazides, NSAIDs (except sulidac and ASA)
Meqs in lithium
8 MEQ= 300 mg carbonate or 5mL citrate solution
How fast can you correct sodium?
12 meq/L in 24 h
IV k+: max concentration and rate for peripheral
Conc: 10meq/100 mL
Rate: 10 meq/hr
IVIG and vaccines
Can impair response to vaccination
IVIG and vaccines
Can impair response to vaccination
IVIG and vaccines
Can impair response to vaccination
IVIG and vaccines
Can impair response to vaccination
Blue nitroprusside
DONT USE- degraded to cyanide
Vasopressor of choice for septic shock
Norepinephrine
Weird lorazepam ADR
Propylene glycol toxicity (AKI and metabolic acidosis)
Drugs that cause malignant hyperthermia
Succinylcholine
Inhaled anesthetics
Lysteda
Tranexamic acid (tab) Could use for heavy men’s that bleeding
Amicar
Aminocaproic acid
Ibuprofen strengths!!
Infant : 50/1.25 ml
Child: 100/5 ml
Age you can give motrin
6 months +
Age you can give motrin
6 months +
Neonatal meningitis (<30 d)
Ampicillin + (cefotaxime OR gentamicin)
RSV tx and ppx
Tx: virazole (inhaled ribaverin)
Ppx: synagis (palivizumab)-
-doses monthly in premature with heart or lung dx during RSV season
Order to CYstic fibrosis drugs
Bronchodilator > hypertonic saline (nebulized) > dornase Alfa > physiotherapy > inhaled ABX
Max pancreatic lipase dose
Lipase <2500u/kg/meal or 10,000u/kg/day
Pancreatic lipase facts
- can mix with acidic food but not dairy
- viokace needs PPI
- original container
- half mealtime dose for snacks
- MEDGUIDE*
Calcineurin inhibitor info (tacrolimus and cyclosporine)
HTN, renal tox!, hyperglycemia, neurotox, lipids, QTC!, hyperK+, hypomag, PHOTOSENSITIVITY
- Non-PVC for IV
- 3A4 and P-GP interactions!!!
- avoid sun- skin cancer risk with transplant patients
Mtor Inhibitors major ADR
Increased lipids
Monoclonal antibody major ADR
Severe reaction: premeditate with steroid, antihistamine, acetaminophen
Weight loss drug reqs
Must lose 5% in 12 weeks to continue
No preganancy
Weight loss drug reqs
Must lose 5% in 12 weeks to continue
No preganancy
Weight loss drug reqs
Must lose 5% in 12 weeks to continue
No preganancy
AC of choice it HIT
Argatroban
If pt on warfarin hey HIT
Stop warfarin- (even though high clot risk) and give vit K
*risk limb gangrene and necrosis with low plt and warfarin
AC of choice with prosthetic heart valve
Warfarin
Xarelto renal dosing
Afib -<50: 15 QD -<15: avoid Tx -<30: avoid
*for tx you take 20 either way- even if renal function 30-50
Dabigatran expiration
4 months after opening
- also: !!original container!!
- and no g-tube!~ dont open capsule!
- skip missed dose if within 6h of next dose!
Warfarin bridge with lmwh
Continue x 5 d and until INR > 2 for at least 24 h
How to give vit k for warfarin reversal
PO/IV NOT SubQ/IM
1 mg/min max!
*give PO if no bleed- give IV if bleed
Inr>10 or >4.5 if risk factors
When to use vit k
If not bleeding: INR> 10
-PO: 2.5-5
Bleeding: 5-10 mg slow IV
-give with PCC
When to stop warfarin before surgery
5 d
*bridge with LMWH if mechanical heart vale (d/c 24 h before or 4-6 h before if UFH)
Preferred tx for DVT or PE
DOAC> warfarin
Cancer: LMWH
CHA2 DS2 VASc
CHF, HTN, Age>75, Diabetes, stroke, vascular dx, age 64-74, sex
Male: 2 needs AC
Female: 3 needs AC
CHA2 DS2 VASc
CHF, HTN, Age>75, Diabetes, stroke, vascular dx, age 64-74, sex
Male: 2 needs AC
Female: 3 needs AC
CHA2 DS2 VASc
CHF, HTN, Age>75, Diabetes, stroke, vascular dx, age 64-74, sex
Male: 2 needs AC
Female: 3 needs AC
CHA2 DS2 VASc
CHF, HTN, Age>75, Diabetes, stroke, vascular dx, age 64-74, sex
Male: 2 needs AC
Female: 3 needs AC
CHA2 DS2 VASc
CHF, HTN, Age>75, Diabetes, stroke, vascular dx, age 64-74, sex
Male: 2 needs AC
Female: 3 needs AC
CHA2 DS2 VASc
CHF, HTN, Age>75, Diabetes, stroke, vascular dx, age 64-74, sex
Male: 2 needs AC
Female: 3 needs AC
Drugs that can cause hemolytic anemia
VALPROATE, dapsone, methylene blue, primaquine, rasburicase, pegloticase, bactrim, nitrofurantoin, levodopa, methyldopa, PCN, cephalosporin, quinine, quinidine, rifampin
Think G6PD deficiency
Drugs that can cause hemolytic anemia
VALPROATE, dapsone, methylene blue, primaquine, rasburicase, pegloticase, bactrim, nitrofurantoin, levodopa, methyldopa, PCN, cephalosporin, quinine, quinidine, rifampin
Think G6PD deficiency
Drugs that can cause hemolytic anemia
VALPROATE, dapsone, methylene blue, primaquine, rasburicase, pegloticase, bactrim, nitrofurantoin, levodopa, methyldopa, PCN, cephalosporin, quinine, quinidine, rifampin
Think G6PD deficiency
Hep B tx
Peg-INF or NRTI
Hep C tx
DAA combo
+/- RBV +/- PEG-INF
Drugs with boxes warnings for liver damage
APAP, isoniazid, ketoconazole, amiodarone, MTX, nevirapine, nefazodone, NRTIs, PTU, tipranavir, valproate,
Bosentan, felbamate, flutamide, leflunamide, teriflunamide, lomitapide, maraviroc, mipomersen, tolcapone
Antipsyches: high v low potency
Low: less EPS, more sedation, and CV (hypotension)
High: more EPS, less sedation
Typical antipsych less known ADRs
Hypotension (also atypical), seizures, sexual ADRs
How to people die from antipsyches (black box)
Stroke
Requirement for invega trinza
Only after Sustina monthly x4 months
Seroquel food?
No, or light meal (ER)
IR doesn’t matter
Seroquel food?
No, or light meal (ER)
IR doesn’t matter
Ziprasidone food
With food!
Asenapine food
No!
Note: tongue numbness
Antipsyches food reqs
With: lurasidone, ziprasidone
Without: seroquel, asenapine
Serious antipsych ADR
NMS
- more with first gen (d/t D2 blockade)
- seroquel/clozapine less
- BZDs, dantrolene, bromocriptine (dopamine agonist)
Preganancy bipolar
Lamotrigine or lurasidone
Lithium ADRs
GI, cognition/confusion, cogwheel rigidity, hand tremor, wt gain OR anorexia, polyuria/dipsia, hypothyroid, blue skin pigment, impotence, serotonergic
Toxicity: arrhythmias, seizures, coma
Amphetamine salts and acid
Don’t take with acid juice- decreases absorption
Stimulants suicidal ideation?
No!
Yes for straterra
Stimulant and straterra differences
ED, libido, hyperhidrosis, suicide, straterra but NOT stimulants
Tamoxifen interactions
Prodrug via 2D6 (no fluoxetine or paroxetine)
Cyp2C9 inhibitor- No warfarin!!!
Inhibitors
Pacman
PIs, azoles, cyclosporin, cimetitinde, cobicistat, macrolide (not azithromycin), amio/dronedarone, non-DHP
Pseudomonas abx
Zosyn, cefepime, ceftazadime, , ceftazolane-tazobactam, aztreonam, carbapenems (not ertapenem), levofloxacin, cipro, AG
Corrected calcium
(4-albumin) x 0.8 + calcium
Extravasation temp management
Cold: anthracyclines (and dimethyl sulfoxide, or dexrazozane “totect”)
Heat: vinca alkaloids (and hyaluronidase)
Which DPIs have slow inhalation
Ellipta
Also handihaler and neohaler aren’t as forceful
Emergency contraception times
Plan b: 120hr (labeled 72)
Ella (ullipristal): 120h- rx only
Copper iud- 5 day (better bmi>35)
Danazol
Androgenic hormone for endometriosis
Elagolix (orilissa)
GnRH antagonist
Endometriosis
Correlation tests
Pearson: continuous, normal distribution
Spearman: not normally distributed or ordinal
Regression vs correlation
Regression shows one variable is dependent on the other (cause and effect)
*regression used for prediction!
Survival analysis
Kaplan Meier- descriptive
Cox proportional hazards- continuous and test multiple
Log rank
Hyperthyroid in pregnancy
1st trimester use PTU- switch to methimazole in second trimester
Levothyroxine iv to po
75%
Thyroid drug pearls
Levothyroxine-T4
Liothyronine- T3
Liotrix- T3/T4
Dedicated thyroid 60 mg= levothyroxine 100 mg
Levothyroxine start: 1.6 mcg/kg IBW
Pasireotide
Cushing’s
Antiarrythmics to use in HF
Amiodarone or dofetilide
NOT dronedarone
Anticoag choice in primary pci
Bivalirudin or UFH
How long to continue AC after pci
Fibrinolytic?
48 hours, up to 8 days
Usually stop after pci
*48 hours after for fibrinolytic
ARNI lab issue
Use NT-proBNP not BNP
ADHF numbers
Wet: pcwp >18
Dry: pcwp 15-18
Cold: CI <2.2
Warm: CI >2.2
ADHF tx
Wet: diuretics (+- venodilator (NTG))
Cold: if SBP <90- inotrope
If SBO >90-arterial vasodilator (nitroprusside)
Cold and dry: Pcwp<15- start w/ IVF…if sbp<90 use inotrope, if sbp>90 use arterial vasodilator (nitroprusside)
Generally avoid pressers- use if SBP< 90 and need initrope
Milrinone v dobutamine
Milrinone: to avoid stopping BB. don’t bolus
Dobutamine: severe hypotension, bradycardia, renal impairment, thrombocytopenia
Tolvaptan
Vasopressin ANTAGONIST
makes you urinate
*opposite of desmopressin
DOC pulseless VT/VF
Amiodarone
Ventricular arrhythmia
Lidocaine or Mexilitine
Fenoldopam
Vasodilator for hypertensive crisis
DOC acute aortic dissection
Labetaolol, esmolol
HTN crisis: DOC pulmonary edema
Clevidipine, NTG, ntp
No BB
Code: v fib or pulseless vtach
Shock
Code non-shockable rhythms (PEA, asystole)
Epi asap
Which antipsychs have less QTc effect
Risperidone and olz
Stress ulcer ppx indication
Mech vent, inr>1.5, or plt<50
When to avoid D5W
Neurological injury (increases ICP) bc it’s “free to cross any membrane
Which fluid should 150 meq sodium bicarb go in
Sterile water or D5W (osmolarity issues)
Demeclocycline
ABX but also for siadh (reduces sensitivity to adh- opposite of desmopressin)
Calcium to use in PN
Gluconate
Chloride more likely to precipitate
Required concentration of AA, ca, and phos
AA: 2.5%+ (decreases ph) 4%for TpN
Ca: 6meq/L or less
Phos: 30-40 mmol/L or less
Tests for heterogeneity
Cochrane Q, X2, I2
P>0.1 means no heterogeneity
Postrenal Aki from drug precipitation. Drug examples
MTX, sulfonamide, acyclovir, ascorbic acid,
Indication for dialysis
Acidosis
Electrolyte abnormality
Intoxication
Overload (fluid)
Uremia
ESA reqs
Start Hgb <10
Stop:
-Hgb >11 (HD) or >10 (non-HD)
Increase 25% if <1 change in 4 wk
Decrease 25% if >1 change in 2 wk
ESA use with caution
Hx stroke or cancer, HTN
ESA SubQ to IV
SubQ is 30% less than iv
Iron formulation in dialysis patients
IV, NOT oral
PPI + IV MTX
Risk MTX toxicity
Bethanecol
Cholinergic AGONIST
For urinary retention
Motrin + ASA
Give Motrin 30 mins after or 8 hours before aspirin
Albumin dosing
Paracentesis: 6-8 g/L if >5 L removed
SBP: 1.5 g/kg d1, 1 g/kg d3
Ribaverin indication
Hep c
Mavyret
Glecaprevir/pibrentasvir
DAA interactions
3A4/ pgp, acid suppressive therapy, statins
Many can cause liver issues
Linaclotide (linzess)
Constipation
Prucalopride (motegrity)
Constipation
Seratonin agonist
Cardiac events and suicide
Lubiprostone (amitiza)
Constipation
No pregnancy
Tenapanor (ibsrela)
Constipation
Peppermint oil use
Nausea, IBS
Tegaserod
IBS-C
Eluxadoline
(Viberzi)
IBS-D (mu agonist)
Alosetron
IBS-D
Lotronex
IBW
50 or 45.5 + 2.3(inches over 5ft)
Adjusted: IBW + 0.4(act-IBW)
Which drugs used actual body wt in crcl calculation
Xarelto, dofetilide, dabigatran
Aducanumab
Alzheimer’s
RA DOC in preganancy
Sulfasalazine
Meningitis is child
0-1 month- amp + gent
1-3 month- amp or vanc + ceftriax
>3 month: vanc + ceftriax
Which vaccines have neomycin
Polio, varicella, mmr
Methylphenidate to dexmethylphenidate
50% reduction
Viloxazine
Like atomoxetine
Which common seizure meds don’t effect birth control
Valproate, levetiracetam, Zonisamide, lacosamide, ethosuxamide
Selegiline patch vs tab
Patch: depression
Tab: PD
Istradefylline
Nourianz
PD
Lumateperone
Atypical antipsych
No EPS
Antipsych movement disorder meds
Akathesia: BB, BZD
Dystonia: anticholinergic (po to prevent, iv to treat)
Pseudoparkinsonism: oral anticholinergic
Traduce dyskinesia: valbenazine, deutetrabenazine, tertabenazine…. DO NOT USE ANTICHOLINERGICS
Antipsyches highest risk seizure
Chlorpromazine, cariprazine, clozapine
If it starts with “c” it causes seizures
Seratonin syndrome treatment
Cyproheptadine, BZD, anticonvulsant, nifedipine
SSRIs with less sexual dysfunction
Vortioxetine, vilazodone
Also mirtazapine
TCA major ADR
Seizures
Half life
0.693/k
Gene that valproate CI in
Polg
Valproate ER to enteric coated
Increase by 8-20%
Valproate toxicity
Thrombocytopenia, hepatotoxicity, alopecia, pancreatitis, fetal harm,
Lamotrigine unique adr
Aseptic meningitis
Symbyax other use
Bipolar
Lemborexant
Insomnia
Sleep onset v sleep maintenance
Which can be used long term?
Both: zolpidem, eszopiclone, suvorexant, temezepam
Onset: ramelteon, zaleplon, triazolam
Maintenance: doxepin,
Note: ramelteon and z-drugs can be used long term
Who should never get anticholinergics? (If you think about it…)
Alzheimer’s pts! Duh!
Which is the T in LOT BZDs ?
Temazepam NOT triazolam
Which is given first thiamine or glucose?
Thiamine
Cofactor for glucose metabolism
Which is the only LAMA for asthma
Spiriva
Add to high dose ICS-LABA for very severe cases
Which LABAs are indicated in asthma
Salmeterol, formoterol, vilanterol
(Salamander for the villains)
** NEVER MONOTHERAPY FOR ASTHMA**
Combos: symbicort, Breo, dulera, advair
Indications for LAMA/LABA VS LAMA/ICS combos
LAMA/LABA: copd
LABA/ICS: asthma
Zileuton and zafirlukast adr
Hepatotoxicity
Not with mintelukast
Montelukast black box warning
Neuropsychiatric events
Monoclonals for asthma
When should they be used?
Omalizumab, dupilimumab, reslizumab, benralizumab, mepolizumab
These are best for allergy related asthma or high eosinophils!
Redihaler
MDI
Aerosphere
MDI
Preferred asthma meds in pregnancy
ICS: budesonide
LABA: salmeterol
Saba and montelukast okay
Is copd what is ICS combined with
LABA of LAMA/LABA (category D)
NOT LAMA alone
Adjusting COPD therapy
If LABA can add ICS
If LABA/ICS- add LAMA or change to LAMA/LABA
If LAMA/LABA- add ICS
If exacerbations if the issue- consider roflumilast, or azithromycin (former smoker)- both of these if eos <100
Note: ICS WHEN EOSINOPHILS >100 or >300
Copd exacerbation ABX
Augmentin, azithromycin, or doxy
Or FQ if suspect pseudomonas
Pneumococcal schedule
Pcv15 follow by pcv23 in 1 yr
Or just pcv20
*for qualifying 19-64 and everyone over 65if haven’t received before
Flu vaccine and egg allergy
Severe- RIV or ccIIV4 or vaccinate in medical setting
If hives only- any vaccine okay
Which FQs cover PSA?
Levo and cipro
Not moxi- important for tx of PNA
PNA duration
Cap 5 d
Hap/vap- 7 d
Baceterial v viral sinusitis
Bacterial: >10d, fever, double sickening
Augmentin first line
Pyleo or complicated uti
Bactrim of FQ, maybe beta lactams (especially ceftriaxone if inpatient )
CAUTI- levaquin
Preganancy uti
Augmentin, cephalexin, fosfomycin
Nitrofurantoin- avoid I. Trimester 1 and 3
Osteomyelitis with prosthetic joint
Add rifampin
Which FQ cover anaerobes ?
Moxifloxacin
*can use for GI infxns without metronidazole!
Gi infection
Anerobes, PSA if high risk
Treat for 4 days
Amphoteracins
Deoxycholate: regular
Liposomal ampho: safer
Cryptococus ppx
No primary (like cmv)
Secondary is fluconazole
Posaconazole vs itraconazole Cap v solution with food
Itra: solution empty, cap w/food
Posa: solution w/ food, cap no matter
Anion gap
(Na + k) - (cl + bicarb)
MAP equation
(Sbp + 2(dbp)) / 3
How many kcal per of per day needed for EN?
30 kcal/kg/day
K=
Cl/vd
Kcal and protein reqs
And fluid
Kcal= 25-30 kcal/kg/day
Protein= 1.3-1.4 g/kg/day
Fluid= 30 ml/kg/day
Meningitis ppx
Niseirria: (for close contacts and oral secretions exposure): rifampin x4 doses, or cipro or ceftriaxone x1 dose
H influenza: (close household contacts if unvaccinated if immunocomprimised): rifampin x4days
Rifampin+ bictegravir/ elvitegravir
Interaction
When are ABX needed for copd exacerbation
All three (increases sputum, purulence, and dyspnea)
OR purulence + one other
OR mech vent
Levothyroxine po to iv
Decrease by 25%
When is tdap given in pregnancy
Weeks 27-36
FENA
(Urine na/serum na)/(urine cr/scr) x100
<1% is prerenal
Inr to switch from warfarin to doac
Apixaban/dabigatran <2
Edoxaban <2.5
Rivarixaban <3
Hasbled
HTN (sbp>160), abnormal liver or renal(1 pt each), stoke, bleeding, labile inr, elderly, drugs or alcohol (1 pt each)
*renal- dialysis, transplant, scr>2.26
*liver- bili>2x, LFTs >3x
*drugs- antiplatelet/ nsaid
*etoh 8+/week
At which dose does fluconazole inhibit cyps
2c9: 100 mg
3a4: 400 mg
Warfarin alleles
2c92, vkorci2- increases metabolism
2c93, vkorci3- decreases metabolism
Hysteresis loops
Concentration late after dose produce different effect than same concentration early after a dose
Counterclockwise: Active metabolite, increased sensitivity, delay in concentration equilibrium. Ex digoxin
Clockwise: tolerance, inhibitor metabolite, pseudophed, cocaine
Pharmacodynamic equation
Hill equation
Drug levels
Phenobarbital: 15-40
Phenytoin: 10-20 (free 1-2)
Cyclosporin: 100-250
When to sample digoxin level
6-12h after dose- prolonged distribution period
*same for lithium but 12h after
When to collect aminoglycoside sample
30 mins after infusion
AC peri-cardio version
3 weeks before and 4 weeks after
Warfarin TIR goal
> 65-75%
Warfarin adjustment
If previously stable and inr +- 0.5- leave the same and recheck 1-2wk
If within 0.1 of goal leave alone
If inr >4.5 consider holding
Otherwise adjust by 5-20%
Dabigatran Bud
Other counseling
4 months after opening bottle
Don’t open caps- decreases BA
Converting between ACs
DOAC to warfarin- bridge til inr>2
(Dabigatran different- bridge with dabigatran not parenteral, edoxoban this is optional)
Doac to other AC- give with next doac dose would have been due
Warfarin to doac- give with inr below respective lvl (2, 2.5, or 3)
Other AC to doac- given doac when 0-2 hr (edoxaban 0hr) before next evening dose due ( if hep gtt stop and start doac at same time except edoxoban which is 4h later)
Edoxoban dosing
60 QD
Crcl<50: 30 QD
Avoid in crcl>95
**unique bc can use in crcl 15-30 for both ppx and tx- for dabig and Xarelto ppx okay but not for tx!
Main benefit of doacs over warfarin
All
-Less hemorrhagic stroke
-Non-inferior for stroke/VTE
Apixaban
-mortality benefit (significant)
-less major bleeding (also edoxaban)
When is warfarin preferred to doac
Mech heart valve and anti phospholipid syndrome
Can doacs be used in obesity?
Yes - xarelto better than Apixaban
Can doacs be used in advance renal disease
Apixiban and xarelto are preferred
Most are avoid in crcl<15
AC and antiplatelet in a pt with NVAF who had pci
Usually stop aspirin at discharge and continue p2y12 for 3-12 months
*takeaway is no AC + DAPT!
AC in bio prosthetic valves
Aspirin or warfarin if low bleed risk
I’d also afib and valve placement >3 months ago then doac is also ok
For mechanical valve always warfarin!
Fondaparinux ppx dose
Dalteparin?
Xarelto?
2.5 mg QD
Dalteparin: 5000 units qd
Xarelto: 10 mg
VTE ppx in trauma pts
Lovenox 30 q12 or Dalt 5000 qd
30 q12 also for spinal cord Injury and icu pts
When is warfarin better than doac for VTE (yes warfarin is ok for VTE)
Renal impairment crcl<30
Fondaparinux VTE dose
<50 kg: 5 QD
50-100 kg: 7.5 QD
>100kg: 10 QD
Note: ACS tx is 2.5 QD
Crcl<30 CI
Dabigatran and edoxaban in VTE
Only after 5-10 days of parenteral AC
Options for cancer related VTE
Lovenox (maybe Xarelto, edoxaban and maybe maybe Apixaban)
Protamine for UFH
1:100 for hr 1
0.5:100 for hr 2
0.25:100 for hr 3
How long to hold doac before surgery
1-2 days
Andexxa dose
Apix 5 mg or xarel 10 mg or >8 h: 400 mg then 4 mg/kg x2 hr
Apix 10 or xarel 15+ within 8 hr: 800 mg then 8 mg/kg x 2 hr
What consistories high grace or timi score (MI)
Timi: 3+
Grace: >140
Antiplatelet surgery hold time
Clop/tic: 5 days
Pras: 7 days
At least a day if emergency
*continue Asa for cabg
Ticafrelor + Asa caveat
Don’t uses Asa doses >100 mg
Gpiibiiia inhibitors- who gets them
Eptifibitide, tirofiban
Elevated bio markers, DM, undergoing revascularization, inadequate pretreatment with p2y12 inhibitors
Renally dosed
AC choice when fibrinolytixs are used for stemi
UFH, Lovenox, fondaparinux
Fibrinolytic CI
Hemorrhagic stoke, ischemic stroke in last 3 months, pregnancy, BP >180/110
How long to continue BB after acs
3 yrs if no HF
Start within 24 hrs if possible
Expected benefit from high intensity statin
50% decrease in ldl
If not can add non-statin
*ideally ldl<70
Life threatening bradycardia
Atropine 1 mg q3-5 mins (max 3 mg)
SVT, sinus tachycardia
Adenosine 6 mg
If fails: CCB or BB
Acute afib of flutter tx
Non-dhp CCB, BB, dig
Meds for cardio version
Ibutilide, amiodarone, propafenone (if within 7 days), dodetilide
I am professor dofus
Amio + dig
Amio + warf
Decrease dig 50%
Decreases warf 30-50%
Antiarrythmics preferred in HF
Amiodarone and doefetilide
Hypertensive emergency
In stroke?
Dec 25% in first hr, then to 160/100 in next 2-6hr, the normal in 1-2d
If ischemic stoke do no lower BP unless>220/120 unless tpa required and >185/110
In hemorrhagic stroke avoid hydralazine, NTG, NTP
NTG indications
Only ACS or pulmonary Edema
Which sglt2 inhibitors used in hf
Dapagliflozin and empagliflozin
Afib rhythm control agents
Class 1c and III
When to start BP med
Stage2 or Stage 1 HTN and ASCVD or 10 yr risk >10%
2 drugs if >150/90
When to use hypertonic saline
Traumatic brain injury
Symptomatic hyponatremia <120
Why is desmopressin given in hyponatremia
To counteract overcorrection of hypertonic saline
When to give calcium gluconate for hyperkalemia
K>6.5, extreme muscle weakness, or ecg changes
Head of bed elevation
30-45 degrees
When to use EN 2kcal/ml formulation instead of 1kcal/ml
Fluid restriction
Filter for 2:1 and 3:1
2: 0.22 micron
3: 1.2 micron
Hang time lipids
12 hours if separated from AA and carbs
TpN kcal/g
Fat 10
AA 4
Carbs 3.4
Asthma symptoms
Step 1: 2 or less days/wk-numbers look good
Step 2: >2d per wk- numbers looks good
Step 3: daily, numbers decreased
When is MRSA and PSA needed in PNA
Hap/vap: use PSA but and mssa not MRSA. Use 2 PSA if risk factors and MRSA if risk factors
PSA resistance >to mono-ABX>10%
MRSA incidence >10-20%
Hospitalization>5d, Ards, Rrt, (vap only)
Mortality risk: ventilator, septic shock
Iv ABX past 90 days
Hap/ vap definition
Hospitalization or vent for >48hs
Complicated uti or pyelo
Bactrim bid x14 d
Cipro bid x7 d
Levo QD x5d
Ceftriaxone or AG in hospital
Pregnant: augmentin, nitrofurantoin (not in trimester 1 or 3), keflex, cefpodoxime, fosfomycin
Meningitis tx duration
Niserieia and influenza: 7 days
Pneumonia: 10-14 days
Algacaae: 14-21d
Listeria : 21 days
HIV regimen in pregnancy
Dual nrti + (insti OR ritonavir booster PI)
IV zidovudine near term unless RNA<50
When to start ART in people with cryptococcus meningitis?
Crypto regimen?
Delay 2-10 wks d/t risk of iris
Note: tx is ampho + flucytosine x2 wk, fluconazole 800 mg x 8 wk then fluconazole 200 mg x 1 yr
Ppx: fluconazole 200 mg QD (for secondary only)- stop after 1 yr of maintenance if cd4>100 x 3 months
Candidemia
Fluconazole ONLY IF KNOWN SUSCEPTIBILITY (400 mg/day
Otherwise echinocandin or ampho
14 days from first neg blood cx
Drugs for cushing’s
Pasireotide, osilodrostat, ketoconazole, mitotane, etomidate, metyrapone, mifepristone (hyperglycemia)
Pregnancy DM goal
Fasting <95
Insulin rules
500/TDI= amount of grams of carbs covered by 1 unit of insulin
Correction: 1800/TDI= amount decrease in BG from 1 unit (use 1500 for regular insulin)
When to start Metformin plus a second agent ?
When A1c > 1.5% above goal
(A1c >8.5 for most people)
Which DM agents best if HF and/ or renal dx
Sglt2
Holding Metformin for constrast
Hold before and for 48h after
Big adr for dpp4 and glp1-
Pancreatitis
When to give bicarb in DKA
Other tx
Ph <6.9
Fluids- 0.45-0.9% nacl til bg<200 the change to D5W/1/2ns
Insulin gtt
K+
Which sglt2 have renal benefits
Dapagliflozin, cabagliflozin
Transplant induction v maintenance
Induction: basilixmab, antithymocyte globulin
Maintenance: tacro and mycophenolate first line
Azathioprine
Mtor: everolimus, sirolimus
Belatecept
Coefficient if variation calculation
SD/mean X 100
95% CI calculation
2x SEM in both directions
SEM= SD/ sqrt of n