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Oncology Flashcards

1
Q

Bleomycin risk and max dose

A

Pulmonary

400 unit lifetime dose

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2
Q

Doxorubicin risk and max dose

A

Cardio toxicity

450-550 mg/m2 lifetime dose

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3
Q

Cisplatin risk and max dose

A

Nephrotoxicity

100 mg/m2 per cycle

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4
Q

Vincristine risk and max dose

A

Neuropathy

2 mg max single dose

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5
Q

Myelosupression

A

All except: asparginase, bleomycin, vincristine, monoclonals and TKIs

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6
Q

N/V most common

A

Cisplatin, cyclophosphamide, ifosfamide

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7
Q

Mucositis

A

5-FU, MTX

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8
Q

Diarrhea

A

Irinotecan, capecitabine, 5-FU, MTX

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9
Q

Constipation

A

Vincristine

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10
Q

QTC

A

Droperidol, arsenic, TKIs

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11
Q

Pulmonary toxicity

A

Bleomycin, busulfan, carmustine, lomustine

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12
Q

Hepatotoxicity

A

Antiandrogens (bicalutamide, flutamide, nilutamide )

MTX

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13
Q

Nephrotoxic

A

Cisplatin, MTX

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14
Q

Hemorrhagic cystitis

A

Ifosfamide, cyclophosphamide

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15
Q

Peripheral neuropathy

A

Vinca alkaloids, platinums, taxanes

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16
Q

Totect

A

Dexrazoxane

Extravasation from doxorubicin

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17
Q

Zinecard

A

Dexrazoxane

Cardio protection from doxorubicin

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18
Q

Ethyol

A

Amifostine

Give with cisplatin to prevent nephrotoxicity

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19
Q

Uridine triacetate

A

5-FU and capecitabine antidote

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20
Q

Mesnex

A

Mesna

Give with ifosfamide to prevent hemorrhagic cystitis

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21
Q

What to give with MTX to reduce toxicity

A

Leucovorin (fusilev)

Glucarpidase (voraxaze)

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22
Q

When does nadir occur

A

7-14 days after chemo

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23
Q

High emetic risk regimen

A

Dex + 5HT3 + NK-1RA

*can add or substitute with olanzapine

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24
Q

Aprepitant alone?

A

No, always add on

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25
Can 5HT3 antagonists cause seratonin syndrome
Yes
26
Does cesamet require refrigeration?
No *drinabinol does
27
TLS
Allopurinol (400-800 mg/d) Or rasburicase Start both IV
28
Hypercalcemia of malignancy tx
Mild: hydration w/ NS and loop diuretics Mod-severe; - calcitonin (miacalcin) - iv bisphosphonates (zometa, pamidronate) * zometa is 4 mg while reclast is 5 mg iv yearly - xgeva 120 mg sc (prolia is 60 mg Q6 months)
29
Dimethyl sulfoxide
For anthracycline extravasation | Can also use dexrazoxane (Toltect)
30
Hyaluronidase
Vinca alkaloid or etoposide extravasation
31
How to prepare vincristine
Don’t make in syringe! To avoid accidental intrathecal administration
32
Vaccine and chemo timing
Vaccines should precede chemo by 2+ weeks | -live at least 3 months after chemo
33
Who gets aromatase inhibitors for breast CA?
Only post menopausal! (Or no uterus) *doesn’t affect ovarian estrogen production
34
Who gets tamoxifen for breast cancer?
Premenopausal! Can give in post menopausal if did not tolerate AI
35
Herceptin
Traztuzumab Her-2 positive breast CA
36
Tamoxifen
SERM
37
Fulvrstrant
SERM | IM injection
38
Toremifene
SERM
39
Arimidex
Anastrazole | AI
40
Femara
Letrozole | AI
41
Exemestane
AI
42
Tx of tamoxifen induced hot flashes and night sweats
Venlafaxine *Not estrogen!!
43
Evista
Raloxifene SERM For breast CA ppx not tx!! Osteoporosis and in post menopausal women
44
Gnrh agonist info
Prostate CA - ADRs: decreases BMD, impotence, gynecomastia - Give with antiandrogen to prevent tumor flare! - works by negative feedback!
45
Zoladex
Goserelin | Gnrh agonist
46
Lupron
Leuprolide | Gnrh agonist
47
Casodex
Bicalutamide | Antiandrogen- given with gnrh agonist to prevent tumor flare
48
Flutamide
Antiandrogen- given with gnrh agonist
49
Cytoxan
Cyclophosphamide Alkylating agent Give mesnex Hemorrhagic cystitis
50
Ifex
Ifosfamide Alkylating agent -give Mesnex -hemorrhagic cystitis
51
Busulfan
Alkylating agent Hemorrhagic cystitis Pulmonary toxicity
52
Carmustine
Alkylating agent Hemorrhagic cystitis Pulmonary toxicity
53
Lomustine
Alkylating agent Hemorrhagic cystitis Pulmonary toxicity
54
Mitomycin
Alkylating agent Vesicant DMSO is antidote
55
Cisplatin toxicity
Nephrotoxic, ototoxic, highly emetigenic, | peripheral neuropathy
56
Doxorubicin
``` Anthracycline Cardiotoxic- max 450-550mg/m2 Vesicant Myelosuppression N/V ```
57
Daunorubicin
Anthracycline | Cardio toxicity
58
Mitoxantrone
Anthracycline Cardio toxicity Blue urine
59
Vinca alkaloids toxicity
IV only!!! - neuropathy - vesicants- use WARM compress and hyaluronidase - constipation - bone marrow suppression- more with vinBlastine
60
Taxanes toxicity
- hepatic metabolism - give BEFORE platinums - hypersensitivity-premeditate - non-PVC!!!
61
Abraxane
Paclitaxel | Albumin bound
62
Camptosar
Irinotecan Topo-1 inhibitor Cholinergic ADRs
63
Etoposide
Topo-2 inhibitor
64
Bleomycin
Topo-2 inhibitor | Pulmonary tox- 400units/life
65
Adrucil
Fluorouracil Hand-foot, diarrhea, mucositis -give with leucovorin -antimetabolite
66
Xeloda
Capecitabine Prodrug if fluorouracil Diarrhea, mucositis, hand and foot -antimetabolite
67
Cytarabine
Antimetabolite
68
Gemcitabine
Antimetabolite
69
Arsenic trioxide
Qtc prolongation
70
Afinitor
Everolimus - mtor inhibitor - mouth ulcers, rash, interstitial lung dx
71
HER-2 toxicity
Cardio toxicity- don’t give with anthracycline
72
Avastin
Bevacizumab VEGF -impair wound healing-don’t give within 28 d of surgery
73
Herceptin
Traztuzumab HER-2 inhibitor -watch echo for HF
74
Cetuximab
EGFR inhibitor Must be KRAS wild type, NOT kras mutation -rash correlates with response!
75
Rituxan
Rituxumab Premeditate with diphen, APAP, steroid Hep B reactivation PML
76
Gleevec
Imatinib TKI Take with food!! Must be Philadelphia chromosome positive to use BCR-ABL
77
Capecitabine food?
With food
78
TKI toxicity
Qtc, hypothyroidism, rash, HTN, hand-foot syndrome, diarrhea, hepatotoxicity
79
SERMs vs AI
SERMs: tamoxifen, toremifene Evista (raloxifene), fulvestrant (faslodex) AI: femara (letrozole), arimidex (anastrizole), exenastane (aromasin)
80
zytiga
Abiraterone | Prostate cancer
81
Zoladex
Goserelin | Prostate cancer
82
Casodex
Bicalutamide | Prostate cancer
83
Eulexin
Flutamide | Prostate cancer
84
Lupron
Leuprolide | Prostate cancer
85
Velcade
Bortezomib
86
Nexavar
Sorafenib | TKI
87
Sutent
Sunitinib | TKI
88
Tasigna
Nilotinib | TKI
89
Sprycel
Dasatinib | TKI
90
Tarceva
Erlitinib | TKI
91
Gleecev, glivec
Imatinib | TKI
92
Yervoy
Ipilimumab | Cancer

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