HIV Flashcards
NRTI toxicity
No cyp interactions Lactic acidosis Hepatomegaly RENAL DOSE (except abacavir)
Ziagen
Abacavir
NRTI
Epivir
Lamivudine
NRTI
Meds also used for hep b
Lamivudive (epivir hbv)
Entecavir- (empty stomach)
Tenofovir (viread (for both))
Emtriva
Emtricitabine
NRTI
Viread
Tenofovir disoprixil fumarate
Nephro osteo fanconi
NRTI
Tenofovir alafenamide
NRTI
Retrovir
Zidovudine
NRTI
Hematologist toxicity (macrocyclic anemia) and myopathy
IV for labor in preganancy
Stavudine
NRTI
Not recommended
Didanosine
NRTI
Not recommended
Empty stomach
NNRTI toxicity
NO RENAL DOSE
CYP3A4 inducers
Hepatotoxicity
Rash (most with nevirapine)
NNRTI food
With : etravirine, rilpivirine
W/o : efavirenz (also QHS)
Edurant
Rilpivirine
NNRTI
With food!!!
QTC, depression/suicide, insomnia
Sustiva
Efavirenz NNRTI Without food!! Bedtime! QTC! Psychiatric symptoms
Doravirine
Pifeltro
NNRTI
Nevirapine
Viramune
NNRTI
More rash than others
Etravirine
Intelence
NNRTI
With food
Protease inhibitors
Navir CYP3a4 inhibitors! NO RENAL!! Hepatotoxicity Always give with booster (ritonavir or cobicistat) Metabolic: HLD lipohyperttrophy Take with food! (GI upset) CVD risk, bleeding, ECG changes Rash
Prezista
Darunavir
Protease inhibitor
SULFA!!!
Reyetaz
Atazanavir
Protease inhibitor
Hyperbilirubinemia!! (Bananavir)
Needs acid!!
Lexiva
Fosamprenavir
Protease inhibitor
SULFA!!
Suspension- NO FOOD!
Crixivan
Indinavir Protease inhibitor Nephrolithiasis Empty stomach Water! Kidney stones!
Kaletra
Lopinavir/ritonavir
Protease inhibitor
HLD (esp. TG)
With food
Viracept
Nelfinavir
PI
Do not boost!
Invirase
Saquinavir
PI
Must give with ritonavir
QTc, nausea
Tipranavir
Aptivus
PI
GIVE WITH RITONAVIR
SULFA!!!
Tyboost
Cobicistat
Take with food
Ritonivir
Novir
PI/ booster
Take with food
Integrate inhibitor toxicity
Tegravir
NO renal except: stribild (don’t start if <70) and genvoya/biktarvi (don’t start if <30)
No cyp interactions
Increased CPK, HA, insomnia
SEPARATE FROM DIVALENT CATIONS
Elvitegravir
Insti
With food
Bictegravir
Insti
Tivicay
Dolutegravir
Insti
Don’t use in pregnancy
Isentress
Raltegravir
Insti
Myopathy/rhabdo
Maraviroc
CCR5 antagonist Stage 1 (stops entering cell) Blocks human cell receptor Need CCR5 positive tropism test Need negative CXCR4 or mixed Hepatotoxicity
Fuzeon
Enfuvirtide
Fusion inhibitor (stage 2)
SC
Trogarzo
Ibalizumab
MDR HIV
Megace
Megesterol
Anorexia with aids
Marinol
Drinabinol
Anorexia with aids
Prep
Truvada po QD
Assess hiv neg before starting and Q3 months
90 at a time max (60 if per RPH protocol)
Pep
Truvada + raltegravir or dolutegravir within 72 hours
Test at baseline, 4-6 wk, 3 month and 6 month
Biktarvy
Bictegravir, emtricitabine, TAF
Don’t start crcl<30
Triumeq
Dolutegravir, abacavir, lamivudine
Truvada
Emtricitabine, TDF
Descovy
Emtricitabine, TAF
Stribild
Elvitegravir, cobicistat, emtricitabine, TDF
Don’t start crcl<70
Genvoya
Elvitegravir, cobicistat, emtricitabine, TAF
Don’t start crcl<30
Atripila
Efavirenz, emtricitabine, TDF
NNRTI based so not first line
Complera
Rilpivirine, emtricitabine, TDF
NNRTI based so not first line
Odefsey
Rilpivirine, emtricitabine, TAF
NNRTI based so not first line
First line
Triumeq, biktarvy
Or combos of Tivicay/isentress with truvada/descovy
INSTI based
Epzicom
Abacavir/lamivudine
Aptivus
Tipranavir
PI
Sulfa allergy
Sulfa allergy
Lexiva (fosamprenavir)
Prezista (darunavir)
Aptivus (tipranavir)
*all protease inhibitors
Paxlovid
Nirmatrelvir/ritonovir
Covid 19- mild-mod- at least 12 yrs and 40kg at risk of progression to severe
Didanosine
Videx ec
NRTI
Empty stomach
Selzentry
Maraviroc
Entry inhibitor
Zidovudine ADR major
Normocytic anemia
Vitekta
Elvitegravir
WITH FOOD!
Entecavir v etravirine
Entecavir: NRTI
Etravirine: NNRTI
Zepatier
Grazoprevir + elvasvir
No regard to food
Hep C
Which PI needs empty stomach
Crixivan (indinavir)
Water though! Kidney stones
unles with ritonavir
And fosamprenavir Susp
Viramune
Nevirapine
NNRTI
More rash
Exviera
Dasabuvir
Hep c
Evotaz
Atazanavir (reyetaz) + tybost (cobicistat)
Prezcobix
Prezista (darunavir) + cobicistat
Baraclude
Entecavir
Hep B
Hepsera
Adefovir
NRTI hep B