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HIV Flashcards

1
Q

NRTI toxicity

A 
No cyp interactions 
Lactic acidosis
Hepatomegaly
RENAL DOSE (except abacavir)
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2
Q

Ziagen

A

Abacavir

NRTI

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3
Q

Epivir

A

Lamivudine

NRTI

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4
Q

Meds also used for hep b

A

Lamivudive (epivir hbv)
Entecavir- (empty stomach)
Tenofovir (viread (for both))

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5
Q

Emtriva

A

Emtricitabine

NRTI

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6
Q

Viread

A

Tenofovir disoprixil fumarate
Nephro osteo fanconi
NRTI

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7
Q

Tenofovir alafenamide

A

NRTI

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8
Q

Retrovir

A

Zidovudine
NRTI
Hematologist toxicity (macrocyclic anemia) and myopathy
IV for labor in preganancy

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9
Q

Stavudine

A

NRTI

Not recommended

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10
Q

Didanosine

A

NRTI
Not recommended
Empty stomach

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11
Q

NNRTI toxicity

A

NO RENAL DOSE
CYP3A4 inducers
Hepatotoxicity
Rash (most with nevirapine)

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12
Q

NNRTI food

A

With : etravirine, rilpivirine

W/o : efavirenz (also QHS)

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13
Q

Edurant

A

Rilpivirine
NNRTI
With food!!!
QTC, depression/suicide, insomnia

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14
Q

Sustiva

A 
Efavirenz
NNRTI
Without food!!
Bedtime! QTC!
Psychiatric symptoms
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15
Q

Doravirine

A

Pifeltro

NNRTI

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16
Q

Nevirapine

A

Viramune
NNRTI
More rash than others

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17
Q

Etravirine

A

Intelence
NNRTI
With food

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18
Q

Protease inhibitors

A 
Navir 
CYP3a4 inhibitors!
NO RENAL!!
Hepatotoxicity 
Always give with booster (ritonavir or cobicistat)
Metabolic: HLD lipohyperttrophy
Take with food! (GI upset)
CVD risk, bleeding, ECG changes
Rash
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19
Q

Prezista

A

Darunavir
Protease inhibitor
SULFA!!!

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20
Q

Reyetaz

A

Atazanavir
Protease inhibitor
Hyperbilirubinemia!! (Bananavir)
Needs acid!!

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21
Q

Lexiva

A

Fosamprenavir
Protease inhibitor
SULFA!!
Suspension- NO FOOD!

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22
Q

Crixivan

A 
Indinavir
Protease inhibitor 
Nephrolithiasis
Empty stomach
Water! Kidney stones!
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23
Q

Kaletra

A

Lopinavir/ritonavir
Protease inhibitor
HLD (esp. TG)
With food

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24
Q

Viracept

A

Nelfinavir
PI
Do not boost!

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25
Q

Invirase

A

Saquinavir
PI
Must give with ritonavir
QTc, nausea

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26
Q

Tipranavir

A

Aptivus
PI
GIVE WITH RITONAVIR
SULFA!!!

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27
Q

Tyboost

A

Cobicistat

Take with food

28
Q

Ritonivir

A

Novir
PI/ booster
Take with food

29
Q

Integrate inhibitor toxicity

A

Tegravir
NO renal except: stribild (don’t start if <70) and genvoya/biktarvi (don’t start if <30)

No cyp interactions
Increased CPK, HA, insomnia
SEPARATE FROM DIVALENT CATIONS

30
Q

Elvitegravir

A

Insti

With food

31
Q

Bictegravir

A

Insti

32
Q

Tivicay

A

Dolutegravir
Insti
Don’t use in pregnancy

33
Q

Isentress

A

Raltegravir
Insti
Myopathy/rhabdo

34
Q

Maraviroc

A 
CCR5 antagonist
Stage 1 (stops entering cell)
Blocks human cell receptor
Need CCR5 positive tropism test
Need negative CXCR4 or mixed
Hepatotoxicity
35
Q

Fuzeon

A

Enfuvirtide
Fusion inhibitor (stage 2)
SC

36
Q

Trogarzo

A

Ibalizumab

MDR HIV

37
Q

Megace

A

Megesterol

Anorexia with aids

38
Q

Marinol

A

Drinabinol

Anorexia with aids

39
Q

Prep

A

Truvada po QD
Assess hiv neg before starting and Q3 months
90 at a time max (60 if per RPH protocol)

40
Q

Pep

A

Truvada + raltegravir or dolutegravir within 72 hours

Test at baseline, 4-6 wk, 3 month and 6 month

41
Q

Biktarvy

A

Bictegravir, emtricitabine, TAF

Don’t start crcl<30

42
Q

Triumeq

A

Dolutegravir, abacavir, lamivudine

43
Q

Truvada

A

Emtricitabine, TDF

44
Q

Descovy

A

Emtricitabine, TAF

45
Q

Stribild

A

Elvitegravir, cobicistat, emtricitabine, TDF

Don’t start crcl<70

46
Q

Genvoya

A

Elvitegravir, cobicistat, emtricitabine, TAF

Don’t start crcl<30

47
Q

Atripila

A

Efavirenz, emtricitabine, TDF

NNRTI based so not first line

48
Q

Complera

A

Rilpivirine, emtricitabine, TDF

NNRTI based so not first line

49
Q

Odefsey

A

Rilpivirine, emtricitabine, TAF

NNRTI based so not first line

50
Q

First line

A

Triumeq, biktarvy

Or combos of Tivicay/isentress with truvada/descovy

INSTI based

51
Q

Epzicom

A

Abacavir/lamivudine

52
Q

Aptivus

A

Tipranavir
PI
Sulfa allergy

53
Q

Sulfa allergy

A

Lexiva (fosamprenavir)
Prezista (darunavir)
Aptivus (tipranavir)
*all protease inhibitors

54
Q

Paxlovid

A

Nirmatrelvir/ritonovir

Covid 19- mild-mod- at least 12 yrs and 40kg at risk of progression to severe

55
Q

Didanosine

A

Videx ec
NRTI
Empty stomach

56
Q

Selzentry

A

Maraviroc

Entry inhibitor

57
Q

Zidovudine ADR major

A

Normocytic anemia

58
Q

Vitekta

A

Elvitegravir

WITH FOOD!

59
Q

Entecavir v etravirine

A

Entecavir: NRTI

Etravirine: NNRTI

60
Q

Zepatier

A

Grazoprevir + elvasvir
No regard to food
Hep C

61
Q

Which PI needs empty stomach

A

Crixivan (indinavir)
Water though! Kidney stones

unles with ritonavir

And fosamprenavir Susp

62
Q

Viramune

A

Nevirapine
NNRTI
More rash

63
Q

Exviera

A

Dasabuvir

Hep c

64
Q

Evotaz

A

Atazanavir (reyetaz) + tybost (cobicistat)

65
Q

Prezcobix

A

Prezista (darunavir) + cobicistat

66
Q

Baraclude

A

Entecavir

Hep B

67
Q

Hepsera

A

Adefovir

NRTI hep B

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