Studies Flashcards
NHAN ES 2
why A1C target is 7
Detect
retinopathy outcomes reduced if A1C =6.5
DCCT
intensive insulin regimen increased glycemic control but increased hypo by 3 fold. slowed progression of microvascular
EDIC
Showed that macro and micro complications are improved with intensive therapy
accord
if you treat >1.5% in pre-existing patient aim for reduction in 1 year not 6 months
ascend
Need to use more asprin in diabetic patients
UKPDS
BP control is more effective than glycemic control for outcomes + metformin decreases Glucose but no effect on complications
SAVOR
saxagliptin found to lead to HF, but is not a class effect
Canvas
Amputation risk in candaglifloxin
Carolina
GLP-1 vs sulf to show hypo improvement on GLP-1
ADOPT
rosiglitazone compared to metformin + glyberide, rosi was more effective but HF
Origin
insulin works but no help to cardio outcomes
Look ahead and Da Qing
exercise works
Advance + VADT
decrease A1C you decrease macrovascular effects