Endocrine and cardiac labs Flashcards

1
Q

Random blood glucose test

A

Taken during non fast
usually for insulin dose monitoring
Critical if <2.6 or >24.9

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2
Q

Fasting blood glucose test

A

no food for 8 hours before and done in the morning
should be <7mmol/L

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3
Q

Oral glucose tolerance test

A

2 hours after 75g glucose load
to test insulin response
<11.1 or 7.8

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4
Q

Hemoglobin A1C test

A

Looks at average glucose level for 3 months
<7% (differs for each patient)

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5
Q

TRH test

A

thyrotropin releasing hormone isn’t released systemically so can’t be measured

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6
Q

TSH test

A

checks circulating hormone 0.2-4 mU/L

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7
Q

T4 test

A

99.9% protein bound and only used for thyroid diagnosis not monitoring

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8
Q

T3 test

A

99.6% protein bound, used of monitoring of thyroid levels

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9
Q

Thyroid level interference

A

some drugs can effect function and levels (lithium, steroids, oral contraceptives, carbamazepine)

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10
Q

Cortisol issues

A

Hard to measure with diurnal increase and drop, also levels change per city and population. Stress or injury and also change levels

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11
Q

ACTH test

A

adrenocorticotropic hormone
should be 1.6-3.9 in Edmonton

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12
Q

Cortisol Test

A

measured usually in the morning in the blood or urine

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13
Q

adrenal insufficiency

A

weakness, fatigues, weight loss, hypoglycaemia

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14
Q

adrenal excess

A

weight fain, redistribution of fat, hypertension, hair growth

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15
Q

Addisons disease

A

Too much ACTH, and little cortisol (adrenals can’t produce)

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16
Q

Cushing disease

A

pituitary ademoma releases ACTH and stimulates lots of cortisol

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17
Q

Cushings syndrome

A

adrenal adenoma
low ACTH and high cortisol
Or drug induced therefore decreased ACTH and cortisol

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18
Q

Cholesterol test

A

Measures total cholesterol in all lipoprotein types
>5.2mmol/L

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19
Q

HDL test

A

check for healthy fats

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20
Q

Apoprotein B

A

> 1.05

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21
Q

Non-HDL test

A

Total cholesterol- HDL

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22
Q

LDL test

A

has estimation formula

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23
Q

Troponin 1 test

A

Looks for heart enzymes and therefore damage
<18 ng/L

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24
Q

Troponin T test

A

Looks for heart enzymes and therefore damage
<14 ng/L

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25
Creatine kinase
Present in many tissues and can be a sign of damage. Has different tags
26
Creatine kinase BB
Creatine kinase from the brain
27
Creatine kinase MM
Creatine kinase from cardiac and skeletal muscles. can increased by exercise, trauma or rhadomyolysis
28
Creatine kinase MB
Creatine kinase from only cardiac muscle can be used to check for damage
29
Thrombocytopenia
Low platelet count from drugs, liver disease or bone marrow issues
30
Thrombocytosis
high platelets, cancers, bone marrow issues, splenectomy, trauma
31
Prothrombin time (PT)
Measures clot time when mixed with Ca+ and thromboplastin. Is produced by liver and is K-dependent Used to calculate the INR and extrinsic pathway clotting
32
INR calc
PTpatient/PTcontrol (control set by WHO)
33
High INR
means patient doesn't clot therefore more bleeding
34
Low INR
means patient clots too fast
35
Partial thromboplastin time
used to monitor unfractionated heparin intrinsic coagulation
36
activated partial thromboplastin time
has activator to increase speed of reaction
37
CBC +/- differential
CBC accounts for all blood factors, differential adds WBC report
38
Hgb
Hemoglobin test provides rough estimate of O2 carrying capacity
39
Hit
hematocrit test provides Volume of RBC as whole blood percentage (40-50%_
40
(MCV)
Mean corpuscular volume test Gives the average size of RBC normocytic, microcytic, macrocytic
41
(MCH)
mean corpuscular hemoglobin test Gives average weight of Hgb per RBC. Is calculated by Hgb/RBC count . can be misleading as size/amount of RBC has to be considered
42
MCHC
mean corpuscular hemoglobin concentration test gives average conc. of Hgb in each RBC. calculated by Hgb/Hct it is little more accurate than MCH
43
RDW
RBC distribution width, is the cell size distribution
44
Ferritin test
This is the storage iron form in the GI Low levels can lead to microcytic hypo chromic anemia
45
microcytic hypochromic anemia
Can be from ferritin deficiency and has Low MCV and MCHC
46
macrocytic normochromic anemia
From B12 deficiency from low stomach acid or diet issues
47
Folic acid
In diet and follows B12 levels leads to macrocytic normochromic anemia
48
ESR
erythrocyte sedimentation rate (Westergren test). tests if inflammation is present if sedimentation takes longer due to inflamm soup
49
reticulocyte count
measures immature RBC which reflects EPO activity, monitoring anemia and response to therapy
50
C-reactive protein
Tests for inflammation, infection and arthritis increase these >100mg/L is severe inflammation
51
Neutrophils segmented
increased by heart attack or medications causing stress response (steroids, epinephrine) decreased by B12 or folic acid deficiency or some drugs
52
Neutrophils Band
immature WBC can increase to >10% if fighting infection
53
lymphocytes test
increased by viral or bacterial infection decreased by immune decreasing drugs and conditions
54
Monocytes test
Elevated due to bacterial infection. can become foam cells when cleaning out BV and start plaque formation
55
Eosinophils test
elevated by parasites or allergic response, can also see increase from ACE inhibitors and antibiotics
56
Basophil test
DON;t know what they do
57
Albumin test
Produced by the liver so good marker of liver function. loss of albumin can lead to edema
58
Clotting factors test
k-dependent factors produced in liver and good marker for liver function, Use INR to measure amount
59
ALT test
alanine aminotransferase, produced in the body but more specific for liver injury
60
AST test
aspartate aminotransferase, produced in the body and liver, sign of organ damage
61
ALT and AST change ratings
<5X mild 5-10x moderate >10x is severe increase
62
ALP test
alkaline phosphatase, transporter at has levels increased due to skeletal disease or biliary obstruction.
63
GTT test
gamma-glutamyl transpeptidase, secondary test to confirm source of ALP increase. if it is elevated it shows hepatobiliary disease, normal indicates muscle or GI issues causing ALP increase
64
Cholestasis
blockage of the biliary ducts. causes increase on ALP and GTT. If ALP in <4x ULN then this is likely. if below check GTT if it is also elevated then cholestasis is likely, if not skeletal or GI is more likely
65
Bilirubin test
Increased by hemolytic anemia, antimalarials, benzos, sulfonamides Counts both conjugated and unconjugated bilirubin
66
LDH test
lactic acid dehydrogenase, made in almost every cell. increase indicates cell damage (liver, lung, lymphoma)
67
Amylase test
elevation could point to inflammation or block of salivary gland
68
Lipase test
elevation could be from pancreas issues, gallbladder blockage
69
BUN
blood urea nitrogen end product of protein metabolism, increase from diet or kidney issues