Structure related proteins Flashcards

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1
Q

Formin

A
  1. nucleation factor of actin protofilament (foreman)

2. (+) asociation

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2
Q

Thymosin

A
  1. prevent actin protofilament assembly by binding to the free monomers
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3
Q

Profilin

A
  1. binds to actin monomers and increase protofilament elongation
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4
Q

Arp Complex

A
  1. consist of ARP2/3, binds to existing protofilament.

2. elongates at 70 degrees from minus end of existing structures

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5
Q

Cofilin

A

Binds to ADP-actin monomer and increases disassembly

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6
Q

Tropomyosin

A

binds to protofilament and adds stability

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7
Q

Fimbrin

A

provides cross-linking to form filopodia

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8
Q

alpha-actinin

A

attach actin to the Z-line, required for muscle contraction

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9
Q

filamin

A

helps to maintain the angle of actin protofilaments at 70 degrees

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10
Q

ERM

A

stabilize protofilament in the cell cortex with respect to cell mitosis

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11
Q

Gamma-TuRc

A

nucleates assembly of microtubule (-)

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12
Q

Kinesin-13

A
  1. aids in catastrophe of microtubules. increasing the free concentration of alpha-beta subunits
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13
Q

XMAP215:

A

stabilizes the (+) and therefore increases polymerization

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14
Q

MAPs

A

stabilize microtubule by binding to the side

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15
Q

MAP2

A

causes loose bundle formation so myosin can penetrate in between. Has a long outward projeciton, and microtubule binding site

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16
Q

Tau

A

consist of microtubule bundling protein. association packs microtubules tightly together. 2 microtubule binding domains and short outward projection

17
Q

Plectin

A

helps link microtubule tips to other molecules or proteins