Proteins of cytoskeleton

Question 1

Formin

Answer 1

1. actin subunit protein

2. nucleates assembly. stays at (+) end

Question 2

Thymosin

Answer 2

actin protein subunit that prevents filament assembly

Question 3

Profilin

Answer 3

actin protein that increases growth at (+) end

Question 4

ARP Complex

Answer 4

actin related protein, nucleates and stays at (-) end.

used by listeria to propel through cytosol

Question 5

Cofilin

Answer 5

actin filament protein. binds ADP-actin—> increase disassembly

Question 6

Gelsolin

Answer 6

cuts sections of actin filaments and binds at the resulting (+) end

Question 7

Capping Protein

Answer 7

prevent assembly/disassembly at the (+) end

Question 8

Tropomyosin

Answer 8

increases stability of filament

Question 9

What proteins induce bundling of the filaments with different forms?

Answer 9

fimbrin, alpha actinin, filamin, spectrin, ERM

Question 10

Staminin

Answer 10

tubulin dimer protein

prevents subunit assembly into polymer

Question 11

gamma-TuRC

Answer 11

tubulin dimer protein

nucelates assembly and stays at (-) end

Question 12

TIPS

Answer 12

associate with (+) end and links microtubule to other structure

Question 13

Kinesin 13

Answer 13

microtubule protein
catastrophe at (+) end

Question 14

Katanin

Answer 14

microtubule protein

sever microtubule

Question 15

MAPS

Answer 15

stabilize microtubule, by side binding

Question 16

XMAP215

Answer 16

stabilize (+) end and enhance microtubule growth

Question 17

Tau, MAP2

Answer 17

cause bundling of microtubule

Question 18

plectin

Answer 18

link microtubule to intermediate filaments

Question 19

Where do microtubule nucleate from?

Answer 19

microtubule organizing centers, that originate by random collision of alpha, beta, gamme subunits

Question 20

What is the function of centrioles?

Answer 20

organize the centrosome matrix to provide proper cell strucutre during duplication

Question 21

The nucleation site of microtubules is (+) or (-)?

Answer 21

(-). the positive region will grow out of the MTOC