Proteins of cytoskeleton Flashcards
Formin
- actin subunit protein
2. nucleates assembly. stays at (+) end
Thymosin
actin protein subunit that prevents filament assembly
Profilin
actin protein that increases growth at (+) end
ARP Complex
actin related protein, nucleates and stays at (-) end.
used by listeria to propel through cytosol
Cofilin
actin filament protein. binds ADP-actin—> increase disassembly
Gelsolin
cuts sections of actin filaments and binds at the resulting (+) end
Capping Protein
prevent assembly/disassembly at the (+) end
Tropomyosin
increases stability of filament
What proteins induce bundling of the filaments with different forms?
fimbrin, alpha actinin, filamin, spectrin, ERM
Staminin
tubulin dimer protein
prevents subunit assembly into polymer
gamma-TuRC
tubulin dimer protein
nucelates assembly and stays at (-) end
TIPS
associate with (+) end and links microtubule to other structure
Kinesin 13
microtubule protein catastrophe at (+) end
Katanin
microtubule protein
sever microtubule
MAPS
stabilize microtubule, by side binding
XMAP215
stabilize (+) end and enhance microtubule growth
Tau, MAP2
cause bundling of microtubule
plectin
link microtubule to intermediate filaments
Where do microtubule nucleate from?
microtubule organizing centers, that originate by random collision of alpha, beta, gamme subunits
What is the function of centrioles?
organize the centrosome matrix to provide proper cell strucutre during duplication
The nucleation site of microtubules is (+) or (-)?
(-). the positive region will grow out of the MTOC
