Stroke, Headache, and HTN Flashcards

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1
Q

Stroke symptoms

A

Symptoms vary: location, severity, type dependent

  • Weakness/numbness face/limbs, one side
  • Confusion, difficulty speaking/understanding
  • Agitation, seizure
  • Vision changes – one/both eyes, visual field cut
  • Difficulty walking, ataxia, loss of coordination
  • Dizziness, vertigo, loss of balance
  • Atraumatic loss of consciousness
  • Sudden, severe headache
  • Visual changes can be stroke!!! If someone cant see out of one eye, this may be a stroke
  • Hemorrhageic are the ones associated with HA! Ischemic strokes are not
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2
Q

Risk Factors for stroke

A
  • TIA or previous CVA – your risk of stroke is phenomenally higher!
  • HTN
  • DM
  • Atrial Fibrillation
  • EtOH, IVDU, stimulants
  • Atherosclerosis
  • High cholesterol
  • Sickle Cell
  • Obesity/inactivity
  • Tobacco
  • Increasing age
    • Young people too!!
  • Heredity
    • Family Hx of CVA
  • Ethnicity
    • African Americans
    • Hispanic Americans
  • Gender
    • Men > Women
    • Women > for SAH
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3
Q

Critical hx for stroke

A
  • When did symptoms begin?
    • Treatment is time dependent
    • When were you/they last normal?
  • Sudden or gradual onset?
  • What are the symptoms, exactly?
  • Symptoms persistent or transient?
  • On anticoagulation??
  • PMHx, prior function, meds, risk factors
  • Trauma? Syncope? N/V?
  • Headache??
  • Ask contraindications for tPA, thrombolytics
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4
Q

Ischemic CVA

A
  • ~85% of all strokes
  • Thrombotic
    • Atherosclerosis, gradual vessel occlusion
    • Sx onset may be gradual, stuttering
    • May have hx TIA
  • Embolic
    • Sudden occlusion; sudden, fixed deficit
    • A fib, cardiac thrombus, endocarditis
  • Early on – no headache
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5
Q

Hemorrhagic CVA

A
  • ~15% of all strokes
  • Intracerebral Hemorrhage
  • Subarachnoid Hemorrhage
  • Causes – vessel ruptures due to:
    • HTN
    • Cocaine, Meth, stimulants
    • Aneurysm bursts open
    • Arteriovenous Malformation (AVM)
    • Trauma while on anticoagulation
  • Headache, ALOC are cardinal sx’s
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6
Q

Brain review

A

-Left is dominant hemisphere:
All right-handed
80% left-handed

-Right is dominant in 20% lefties

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7
Q

Stroke syndromes

A

Anterior circulation CVA

  • Carotid artery origin
    • Anterior Cerebral Artery
    • Middle Cerebral Artery

Posterior circulation CVA

  • Vertebral artery origin
    • Posterior Cerebral Artery
    • Vertebrobasilar stroke
    • Cerebellar stroke

Lacunar strokes

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8
Q

Anterior circulation CVA - anterior cerebral artery

A
  • Motor: Contralateral weakness
    • Leg, foot > arm
  • Sensory: Contralateral deficit
    • Leg sx’s > arm sx’s
  • Loss of frontal lobe control
    • Personality change
    • Perseveration – repeat yourself over and over again
    • Incontinence
    • Gait disturbances
    • Apraxia – can’t perform tasks or follow commands even though they know the task and wish to follow the command. Several specific types – you cannot execute something you understand
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9
Q

anterior circulation CVA - middle cerebral artery

A
  • Most common – bad if big/central
  • Motor: Contralateral weakness
    • Face/arms > legs
    • Facial droop
  • Sensory: Contralateral deficit
    • Arms > legs
  • Dominant hemisphere: aphasia
  • Non-dominant: neglect
  • Eyes turned toward side of stroke
  • Homonymous hemianopsia – look at next slide for example
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10
Q

Posterior circulation CVA - Posterior cerebral artery

A
  • Occipital cortex affected
  • Vision loss, cortical blindness
    • Normal eye, eye reflexes
    • May go un-noticed by patient
    • Homonymous hemianopsia
  • Ipsilateral CN 3 palsy
  • Minimal motor findings
    • Contralateral
  • Cortical blindness – when the person has a normal looking eye and reflexes but they cant see!
  • This visual change may go completely unnoticed by the pt
  • homonymus hemanopsia - see half of vision on same side on each eye
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11
Q

posterior circulation CVA - vertebrobasilar CVA

A
  • Ipsilateral eye, cranial nerve defects
  • Contralateral motor defects
  • Vertigo/ataxia, nausea/vomiting – this is the central cause of vertigo! This is what we are looking for with vertigo!
  • Tinnitus/deafness, nystagmus
  • LOC or ALOC, coma
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12
Q

posterior circulation CVA - basilar artery/pontine

A

-“locked-in” syndrome - can move the eyes but cant move any other muscle or body part
-Extensive motor deficit
Consciousness, eye movements spared

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13
Q

posterior circulation CVA - cerebellar strokes

A
  • Central vertigo, vertical nystagmus
  • Cranial nerve deficits
  • Abnormal finger->nose, RRAM, etc
  • Ataxia
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14
Q

lacunar infarcts

A
  • HTN, DM
  • Small vessels that perforate the deep, subcortical areas
  • “pure” motor or sensory sx’s
  • “clumsy hand” syndrome
  • Persistent sx’s need w/u: CT, MRI
  • Old, minor lacunar infarcts often seen incidentally on CT
  • You will see these on CTs incidentally
  • Whats the difference between TIA and lacunar stroke? Location (lacunar strokes are very deep inside the brain), the hallmark of TIAs is that it doesn’t leave a residual, so you cant see it on CT
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15
Q

NIHSS (national institutes of health stroke scale (abbreviated))

A
  • By EMS and on arrival to ED – ALL stroke pt’s
  • Provides info on:
  • Location
  • Severity
  • Prognosis
    • Initial score <15 better
    • Initial score >20 not so good
  • A must in communication with consultants
  • Influences Tx decisions: tPA, transfer, etc
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16
Q

ED workup of stroke

A
  • Recognition first, ABCDE’s, D-stick
  • IV, O2, monitor, EKG, CBC (platelets), CMP PT/INR, troponin, utox, upreg
  • NIHSS score
  • CT brain non-con: then CTA (angiography) brain/neck if significant sx’s and ischemic
  • Non-contrast may be normal for hours if ischemic
  • Ischemic? No gross blood?
    • Call Neurology/Stroke Team: tPA or are they candidate for interventional procedure?
  • Hemorrhagic? Gross blood on CT?
    • Call Neurosurgery
  • D is for disability
  • D-stick – it is one of the only things you need before giving tPA
  • D-stick is dextrose or glucose stick
  • CT is important!!! FIRST THING TO GET IS WITHOUT CONTRAST!! Is it ischemic or hemorrhagic?
  • While the pt is in the CT, it is looked at – if it is ischemic (CT is negative for blood but sxs are significant), you get CTA of brain and neck
17
Q

treatment of ischemic stroke

A

PRESERVE THE PENUMBRA

  • Blood pressure control
    • Avoid acute drop in BP. Raise BP if very low
    • Tx BP if >220/120, MAP goal
    • Labetolol, Nicardipine - easy to titrate IV
    • Goal: situation/tPA or not/end-organ issues
  • Aspirin
    • To prevent recurrent event
    • OK before thrombolytics
  • Thrombolytics
    • Maximize flow to penumbra
    • Save brain tissue
    • BP must be <185/110 for tPA

*Thrombectomy, advanced CT/MRI

  • MAP = SBP + (2 X DBP) ÷ 3
  • Normal MAP 70-110
  • MAP can be higher in acute ischemic stroke (up to 120)
  • Need at least MAP of 60 to perfuse coronary arteries
  • TIME IS BRAIN
18
Q

thrombolytics in ischemic stroke

A

tPA (Ateplase)

  • <3-4.5hrs post sx onset
  • Goal = door to tPA <60min (Stroke Center <30min)
  • May improve outcome
  • Hemorrhage risk
  • Function, not life-saving

Who might benefit:

  • Any adult over 18
  • Anterior circulation stroke
  • Moderate neuro deficit
  • Known time of onset
  • CT: no hemorrhage

Do NOT give it:

  • ANY blood on CT, SAH
  • Seizure at onset
  • Hx hemorrhagic CVA
  • Known tumor, AVN
  • Very minor strokes
  • Recent trauma, LP, arterial puncture*, surgery, GI bleed
  • Can’t control BP
  • On coumadin*, recent heparin, <1k platelets
19
Q

Carotid Dissection

A
  • Sudden onset ischemic stroke after trauma, neck manipulation, minor trauma
  • Spontaneous: family hx, genetic, CAD
  • HA, neck/face pain, partial Horner’s Syndrome, Cranial Nerve abnormalities
  • Young w/ CVA or CN issues
  • Diagnosis: CT angio of neck, MRI
20
Q

Sickle cell

A
  • > 20% (1 in 5) of patients with sickle cell disease have ischemic CVA’s by the age of 45
  • Most common cause of stroke in children
  • Think about ICB/SAH too
  • Horner’s Syndrome = ptosis, miosis, anhydrosis
  • Miosis = pupil constriction
  • Mydriasis = pupil dilation
21
Q

Treatment of hemorrhagic CVA

A
  • ABCDE’s
  • Control BP carefully
  • Neurosurgical consult
  • Multi-detector CT angiography/MRI
    • After initial ED dx
22
Q

Stroke Mimics

A
  • Hypoglycemia – get a d-stick right away
  • Seizure
    • Prolonged post-ictal state, Todd’s paralysis
  • Complicated migraine
  • Sepsis
  • Toxic/metabolic/neurologic conditions
    • OD, Wernicke’s, peripheral neuropathy, demyelinating conditions, Lyme’s, etc
  • Brain tumor or spinal cord tumor/met
  • Isolated cranial nerve abnormalities
    • Bell’s Palsy, 6th nerve palsy
  • Functional (psych) disturbance

-Todd’s paralysis – prolonged partial or complete paralysis, usually unilateral, after a generalized seizure. Can last up to 36-48hrs

23
Q

Transient Ischemic Attack

A

-Ischemia causing neuro deficit without infarct (official definition)
-Stroke-like symptoms lasting < 24 hours and usually 1-2hrs which completely resolve
-Risks same as CVA
TIA = risk for future CVA
-Risk of CVA measured in 2, 7, 30, 90 days
-Big risks, large vessel Dz, significant sx’s - all increase CVA risk
-ABCD2 score helps predict future stroke risk
-Age, BP, clinical features of TIA, duration, diabetes
-> or = 4: higher risk stroke in 2 days; higher score = greater risk
-Careful Hx and PE: thorough neuro exam, risk + sx pattern

24
Q

Treatment of transient ischemic attack

A
  • CT brain non-con first
    • Should be normal if TIA
  • O2, IV, monitor + d-stick
  • Labs, EKG, PT/INR, troponin
  • Aspirin (if no blood on CT)
  • Workup also includes:
    • Duplex US of carotids
    • Echocardiography
    • MRI brain
    • CTA or MRA of neck vessels
  • Admit/Observation unit:
    • TIA w/ mod/high ABCD2, high risk pt
    • “stuttering” or “crescendo” TIA
  • Neurology consult
  • Consider antiplatlet tx, anticoagulation for: moderate/high ABCD2 score, stuttering or crescendo TIA
25
Q

Red flags: hx in headache

A
  • “worst”, “different”
  • Sudden onset
  • New
  • Exertional
  • Fever
  • Stiff neck
  • Vision loss/eye sx’s
  • ALOC
  • Focal deficit on exam
  • Trauma/fall
  • Coumadin
  • Etoh
  • Syncope
  • HIV, cancer
  • Sickle cell disease
  • Multiple patients from same location
26
Q

what is the ED ddx for HA

A

-Subarachnoid Hemorrhage
-Hemorrhagic CVA
-Subdural/Epidural Hematoma
-Meningitis
-Idiopathic (Benign) Intracranial Hypertension
-Hydrocephalus
-Glaucoma
-Giant Cell (Temporal) Arteritis – older people – have temporal pain and often also have lymphoma
-Cavernous Sinus Thrombosis – usually follows a dental infection
-Carbon Monoxide
-Tumor, mets
-Abscess, encephalitis
Etc…
-Migraine, tension, cluster, others after the above

-Cavernous Sinus Thrombosis: septic thrombosis, usually a complication of face/periorbital/sinus/dental infection. HA, CN abnormalities, fever, unilateral eye sx’s that progress bilaterally are hallmarks. Fulminant process, very sick pt. CT with contrast followed by MRI with contrast. ICU admit, big antibiotics, ophthalmology and general and/or neurosurgery consults.

27
Q

important points on the physical exam for HA

A

-Mental status, temperature and blood pressure
Eye exam, including fundoscopy
-Neuro exam: CN, strength, sensory, gait, cerebellar
-Neck: Meningeal Signs
-HEENT: periorbital/dental/facial infection? Older pt’s palpate the temporal artery!
-Rash
-After the Hx and PE cross the unlikely Dx’s off the list. Tx/test for most likely – be able to “tell the story” of each and why it is off or on your list

28
Q

Red flags: who gets a CT scan

A

-Sudden, “worst HA”, especially if onset during exertion
-HA plus fever, stiff neck
-HA plus vomiting and no hx same sx’s in past
-HA plus neuro findings (CN, focal findings)
New HA after/with facial, sinus, dental infection
-HA in young, obese female, +/-papilledema
-HA plus seizure or syncope
-HA plus trauma, fall or EtOH
>50, new HA (likely not new migraine Dx after age 50)
-New HA plus cancer, HIV, pregnancy, coumadin

29
Q

Who needs a lumbar puncture

A
  • Sudden, worst HA
  • HA plus fever, stiff neck
  • ALOC plus HA
  • HA in young, obese female
  • New HA in HIV pt
  • Looking for infection, blood, increased intracranial pressure
  • CT generally precedes lumbar puncture
  • No LP if midline shift, blood or mass on CT (herniation…)

-You are immunocompetent if CD4 > 200

30
Q

tx of HA in the ED

A
  • If no Red Flags on Hx/PE:
  • Labs: D-stick, Upreg. Special: ESR, PT/INR
  • Treatment – migraine or non-specific HA
    • IV hydration – esp w/ vomiting
    • NSAID, anti-emetic, antihistamine IM/IV (NSAIDS: oral; IM/IV Ketorolac, Anti-emetics – Metoclopramide, Compazine or Phenergan IM/IV, Antihistamines – Benadryl IM/IV)
  • Steroids – Dexamethasone 8-10mg IM/IV
  • Serotonin blockers: DHE, triptans – migraine specific
  • Avoid narcotics!
  • Home if:
    • Pain less/gone
    • Can take po’s/walk
    • No new neuro deficit or change in VS
  • Give return precautions, should not drive self home
  • Rx oral NSAID, anti-emetic and/or triptan: Dx specific
31
Q

HTN in the ED

A
  • Really, really common
  • High? Check it yourself, both arms, correct sized cuff
  • BP readings change during an ED visit!
  • Most important questions:
    • Is this an accurate reading?
    • How rapidly did it get this high?
    • Does the patient have symptoms?
    • Is there evidence of end-organ damage?
  • Most important concept:
    • Autoregulation in HTN sets perfusion pressures high - chronically
    • Precipitous drop in BP = less perfusion
    • If slow onset, pt stable – treat slowly
32
Q

HTN red flags

A

-is HTN causing the red flag or is the red flag causing the HTN

  • Headache: sudden or severe or new HA w/ HTN
  • Neuro complaints: weakness, confusion, ataxia: CVA, encephalopathy
  • Visual changes: CVA, optic ischemia, papilledema
  • Chest pain: ACS; TAD (pulses equal?)
  • SOB, DOE, edema: L/R pump failure: new CHF?
  • Abdominal/Back pain: AAA
  • Urine changes – foamy, blood? Think new renal failure
  • Syncope: CVA, SAH
  • Seizure: CVA, hemorrhage, Tox
  • On meds – still HTN – consider secondary causes or under-tx
  • Pregnancy – preeclampsia, eclampsia
  • Hyperthyroid, Tox
  • End-organ damage usually involves kidney, heart, brain

Secondary causes of HTN: CPR squared: 2 C’s, 2 P’s, 2 R’s

  • C’s: Cushing’s, Coarctation of the aorta
  • P’s: Hyperparathyroidism, pheochromocytoma
  • R’s: Renal parynchemal dz (glomerular, polycystic), renal vascular dz
  • Others: Diabetic nephropathy, sleep apnea, obesity, thyroid, stimulants
33
Q

Managing HTN in ED

A

New Dx of HTN – persistent readings >160/100

  • No prior dx/tx but no sx’s, appears well
  • Repeat BP after pain control
  • Initiate work up, secure f/u
  • Begin meds: if SBP >180, high risk for cardiac event w/in 1yr
  • Discharge home, educate

Hypertension – poorly controlled

  • Long-standing dx, no sx’s, appears well
  • Out of meds common, no secure follow-up
  • Testing as outpt if secure f/u
  • Give meds in ED, refill meds
  • BP must respond to tx
  • Discharge home, educate
  • New HTN Testing: CBC, CMP, UA, Upreg, Tox screen, EKG, CXR; Urine microalbumin, TSH, Lipids (as outpt?)
  • New HTN tx: Amlodipine, HCTZ, ACEI, etc…start with one w/ close f/u**
  • Recheck BP while labs are cooking after tx in ED
34
Q

when HTN is a problem

A

Hypertensive Urgency

  • DPB 120-140mmHg or persistent systolic BP >180
  • Usually “poorly controlled” HTN – not sudden
  • In HTN urgency, NO signs/sx’s of end-organ damage
  • They are at imminent risk
  • Order labs, UA, EKG, CXR
  • Oral tx in ED while waiting for labs/diagnostics
  • Home with Rx if BP responds and still NO signs/sx’s
  • Secure f/u
  • Educate
  • Their numbers are very high but they have NO signs of end organ damage
35
Q

the HTN crisis

A

Hypertensive Emergency (Malignant HTN)

  • DBP >130 or persistent sys BP >180 w/ signs/sx’s
  • Hx HTN; rapid, acute elevation
  • End-organ dysfunction is evident – flash pulmonary edema is common
    • Symptoms: chest pain, SOB, ALOC, etc
    • Lab/Diagnostics
  • Reduce BP in the ED – goal is 25% reduction of MAP over 30-60min. (IV: Labetolol, Nicardipine, Nitrates)
  • Tx end-organ damage
  • Admit all
  • MAP = [(2 x diastolic)+systolic] / 3
  • Normal range = 70-110
  • MAP <60 risks underperfusion of organs