Stroke and things

Question 1

Dig target levels + when to take dose

Answer 1

1.5-2

Take levels 6 hours post dose

Question 2

Amiodarone and digoxin - what is the interaction and mod of action

Answer 2

Amiodarone increases digoxin concentrations by inhibiting the P-glycoprotein (P-gp) mediated efflux transporter on the apical surface of the intestinal enterocyte, biliary canalicular membrane and the renal tubular cells that facilitates the elimination of digoxin from the body.

Question 3

stroke BP target

Answer 3

<130/80 mmHg

Question 4

Grades of hypertension

Answer 4

Grade 1 - 140/90
Grade 20 - 160/100
Grade 3 - 180 / 110

Question 5

Should people with grade one be offered antihypertensive treatment?

Answer 5

If:
◦ target organ damage
◦ established cardiovascular disease
◦ renal disease
◦ diabetes
◦ a 10-year cardiovascular risk equivalent to 20% or greater