Diabetes classes

Question 1

Target Hba1C

Answer 1

48mmol/mol

Question 2

When stopping VRII when do you give sc insulin

Answer 2

30 mins before stopping IV

Question 3

Sitagliptin class and MOA

Answer 3

DDP4 inhibitor
Increases incretins > increases insulin secretion

(DD4 breaks down incretins)

Question 4

Diabetic drugs of choice in pregnancy

Answer 4

Metformin +/- insulin

Question 5

Canigaflozin class and MOA

Answer 5

SGLT2 Inhibitor

Works in the kidneys to increase the renal excretion of glucose

Question 6

SGLT2 warnings

Answer 6

Risk of DKA

Question 7

Class of liraglutide

Answer 7

GLP1 AGonist (like exenatide
Activates GLP1 > increases insulin secretion + supresses glucagon + delays gastric emptying

Question 8

Target BP in diabetes

Answer 8

140/80 or 130/80 with target organ damae

Question 9

Contraindicated drugs in diabetes

Answer 9

Thiazides and betablockers

Question 10

Is aspirin used for primary prophylaxis?

Answer 10

non

Question 11

1st, 2nd, 3rd line nephropathy

Answer 11

duloxetine
gabapentin
pregabalin (expensive)
- alphabetical order

Question 12

Class and MOA of repaglinide & Nateglinide

When to take?

Answer 12

Meglitinides
Stimulate insulin secretion

Short acting therefore take shortly before meals

Question 13

Class and MOA of Acarbose?

Answer 13

Alpha-glucosidase inhibitors prolong the absorption of carbohydrates and thus help to prevent postprandial glucose surges.

Question 14

Class and MOA of pioglitasone?

Answer 14

Thiazolindone

Thiazolidinediones reduce insulin resistance in the periphery (ie, they sensitize muscle and fat to the actions of insulin) by activation of PPAR

Question 15

Caution with pioglitazone? (2)

Answer 15

Bladder cancer and cardiovascular safety