stroke Flashcards

(49 cards)

1
Q

how is stroke defined

A

rapid onset cerebral deficit lasting >24h or leading to death with no other cause apparent other than a vascular one

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2
Q

what is the definition of TIA

A

brief episode of neurological deficit temporary focal cerebral or retinal ischaemia without infarction. seconds to minutes with complete recovery

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3
Q

what are the types of stroke

A

ischaemic, haemorrhagic, other (dissection, venous, vasculitis)

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4
Q

what leads to ischaemic stroke

A

thrombotic, large artery stenosis, small vessel disease, cardioembolic, hypoperfusion

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5
Q

what causes haemorrhagic stroke

A

intracranial haemorrhage and subarach haem

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6
Q

what is the most modifiable risk factor for stroke

A

hypertension

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7
Q

features of TIA (anterior system)

A

amaurosis fugax, hemiparesis, aphasia, hemisensory loss, hemianopic visual loss

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8
Q

features of TIA (posterior system)

A

diplopia, vertigo, vomiting; ataxia, choking and dysarthria, hemisensory loss, visual loss, tetraparesis, LOC

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9
Q

what is amaurosis fugax

A

suddent transient visual loss in one eye- emboli in retinal artery. shows internal carotid stenosis

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10
Q

differential diagnosis TIA

A

hypoglycaemia, migraine with aura, focal epilepsy, hyperventilation, retinal bleeds

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11
Q

tests in TIA

A

FBC, ESR, U&Es, glucose, lipids, CXR, ECG, carotid doppler and angio, CT or MRI

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12
Q

which circulation carries a higher risk for stroke and MI

A

anterior circulation

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13
Q

what is the ABCD2 score used for

A

stratify risk of stroke in the first 2 days after TIA

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14
Q

what is the ABCD2

A

Age >60; BP >140 systolic and or >90 diastolic; Clinical features- unilateral weakness (2), isolated speech disturbance (1), other (0); duration of symptoms in mins >60 (2), 10-59 (1),

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15
Q

what is high risk on the ABCD2 score

A

6 high risk

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16
Q

treatment of TIA

A

control cardio risk factors; antiplatelets- clopidogrel, aspirin, dipyridamole; warfarin in cardiac emboli; carotid endarterectomy if >70% stenosis do surgery within 2 weeks. endovascular carotid stenting is an alternative

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17
Q

what is the ischaemic penumbra

A

swollen area around the infarcted region which doesnt function but is structurally intact and can regain function

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18
Q

what features are seen in stroke

A

contralateral hemiplegia or hemiparesis with facial weakness, weak limbs at first flaccid and areflexic, conciousness usually preserved

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19
Q

causes of stroke

A

small vessel occlusion, atherothromboembolism, CNS bleeds

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20
Q

other causes of stroke to consider especially in younger patients

A

sudden drop in bp >40mmHg boundary zone/watershed stroke eg in sepsis; dissection; vasculitis; SAH

21
Q

features of cerebral infarction

A

contralat sensory loss or hemiplegia, dysphasia, homonymous hemianopia

22
Q

features of brainstem infarction

A

quadriplegia, disturbances gaze and vision, locked in syndrome, coma, psuedobulbar palsy, lateral medullary syndrome

23
Q

what is lateral medullary syndrome

A

posterior inferior cerebellar artery (PICA) or one vertebral artery. Wallenberg syndrome. acute vertigo with cerebellar signs

24
Q

features of lacunar infarct

A

small infarcts seen on MRI often asymptomatic. minor strokes- ataxic hemiparesis, pure motor, pure sensory, sensorimotor, dysarthria/clumsy hand

25
what is Webers syndrome
ipsilateral 3rd nerve palsy with contralat hemiparesis, unilateral infarct in the midbrain
26
hemi/tetraparesis
corticospinal tracts
27
sensory loss
medial lemniscus/spinothalamic tracts
28
diplopia
oculomotor
29
facial numbness
5th nerve
30
facial weakness
7th nerve
31
nystagmus/vertigo
vestibular connections
32
coma/altered conciousness
reticular formation
33
left MCA
right weakness, involve face arm > leg with dysphagia
34
right MCA
left weakness face and arm > leg with visual and or sensory neglect
35
lateral medulla- posterior inferior cerebral artery
ipsilateral horners syndrome, Xth palsy, facial sensory loss, limb ataxi
36
posterior cerebral arery
homonymous hemianopia
37
internal capsule
motor, sensory, sensorimotor loss. face=arm=leg. dysarthria
38
carotid artery dissection
ipsilateral horners syndrome- compression of sympathetic plexus around the carotid artery
39
stroke general management at first
airways, O2, monitor BP, look for source of emboli
40
brain imaging in stroke
non contrast CT shows haemorrhage immediately so can be used to rule out; diffusion weighted MRI shows infarction straight away
41
signs that it is likely to be a haemorrhagic stroke
decr GCS, signs incr ICP, severe headache, meningism, progressive symptoms
42
if CT excludes haemorrhage
thrombolytic therapy immediately, if contraindicated then aspirin 300mg/day
43
if CT shows haemorrhage
give no drugs that can interfere with clotting, neurosurgery
44
when can thrombolysis be used
45
what is the thrombolysis agent and dose
recombinant tissue plasminogen activator (tPA)- alteplase. 0.9mg/kg. 10% total dose in first minute bolus then remainder over 60 mins
46
CI to thrombolysis
have to be >18. major infarct/haem; mild/non disabling deficit; recent birth, trauma, surgery, artery/venous puncture at uncompressible site; past CNS bleed; AVM/aneurysm; severe liver disease; anticoags or INR
47
medication after stroke
clopidogrel monotherapy, aspirin or dipyridamole used if clopidogrel CI. warfarin 2 weeks after stroke if due to AF (antiplatelets until then)
48
complications after stroke
aspiration pneumonia, pressure sores, contractures, constipation, depression
49
signs lateral medullary syndrome
vertigo, vomiting, dysphagia, nystagmus, ipsilat ataxia, soft palate paralysis, ipsilat horners, crossed pattern sensory loss- analgesia to pin prick on ipsilateral face and contralateral trunk