stress Flashcards
stress
any significant disturbance in homeostasis
stressor
stimulus/agent that causes stress, or change in homeostasis; anything that changes overall arousal whether positive or negative
stress response
physiological, behavioral, or psychological response to stressor with a goal of re-establishing homeostasis
how stress is measured in animals
- restraint
- forced swim
- cold exposure
- dominance hierarchies **both alpha and sub stressed, magnitude of stress depends on species
- predator
- fear conditioning
- chronic variable stress
Canon: emergency theory of adrenal function
epinephrine released in response to stressor from adrenal medulla as a means of adapting to that stress
epinephrine and fight or flight response
automatic and endocrine responses that prepare an individual to fight or flight from a real or perceived attack, harm, or threats to survival
sympathetic NS anatomy
- thoracic lumbar
- short PRE ganglion neurons, long POST ganglion neurons
- short pre ganglion neurons synapse onto sympathetic chain ganglion
parasympathetic NS anatomy
- cranial and sacral
- long pre ganglion neurons, short post ganglion neurons
HPA axis
CRH–> ACTH–> cortisol (neg feedback on AP and Hypo)–> effects on metabolism (feed back on stressor to bring back body to homeostasis)
effects of cortisol
- maintain blood pressure
- regulate cardiovascular function
- increase blood glucose (decrease insulin)–> want to use, not store energy
- regulate metabolism
- decrease immune response (energy intensive)
- decrease inflammation
adaptive nature of stress response
-increase immediate available energy increase oxygen decrease blood flow to areas not necessary for movement inhibit energetically taxing processes decrease pain perception enhance sensory functioning and memory
pathological signs of stress
peptic ulcers
adrenal hypertrophy
atrophy of thymus, spleen, lymph nodes
negative effects on cognition and memory
chronic stress and dendritic morphology
decrease in DS length, dendritic spine density, and change in shape
HOWEVER can be reversed with rest and recovery (removal of stressor)
cortisol and impairment of feedback pathway in hippocampus
chronic stress–> excessive release of cortisol–> damage of hippocampal neurons that feed onto the hypothalamus (can’t tell hypothalamus to turn of secretion of RH)–> unchecked CRH, ACTH, and cortisol–> more cortisol–> more destruction…
in healthy person, cortisol feeds back on hypo and AP to shut off RH and tropic hormones
psychosocial elements of chronic stress
- sense of control
- predictability
- frustration outlets
- social supports
- social rank (rats sub> alpha; dogs and mongooses a>s)
- social stability
- early life experiences