Streptococcus pneumoniae Flashcards
1
Q
leading cause of
A
pneumonia
meningitis
otitis media
2
Q
colonize in
A
nasopharynx
3
Q
pathogenesis
A
- pneumococcal polysaccharides capsule interferes with phagocyte recognition and engulfment
- pneumolysin (reuire autolysin) stimulate cytokines, disrupt the cilia of human respiratory endothelial cells and facilitate S. pneumonia to alveoli and spread beyond into the bloodstream. It suppresses host inflammatory and immune functions
- neuraminidase cleaves sialic acid that is present in host mucin (a type of glycoprotein)
4
Q
hemolysis
A
alpha hemolysis, green in blood agar
5
Q
treatment
A
penicillin and cephalosporins (ceftriaxone and cefotaxime)
6
Q
pneumonia symptoms
A
shaking chill and fever
productive cough, sputum pink to rusty
pleuritic chest pain
