Stomach Flashcards

1
Q

What is the surface epithelium of the mucosa of the stomach

A

Simple columnar

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2
Q

What type of cells are found in the mucosa of the stomach

A

Surface

Regenerative cells

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3
Q

What is the function of surface mucous

A

Produce- thick visible mucus

Secrete- bicarbonate ions

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4
Q

what is the lamina propia like in the stomach

A

Loose, vascular CT, present in small amounts between glands

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5
Q

What is the muscularis mucosae of the mucosa in the stomach like

A
  1. Inner circular
  2. Outer longitudinal
  3. Outermost circular/ oblique

WELL DEVELOPED

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6
Q

What is the Submucosa of the stomach like

A

Highly vascular

Location of AVA= arteriovenous anastomosis TQ

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7
Q

What is the function of the AVA

A

To shut down activity and secretion FAST in the stomach

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8
Q

Where is the AVA found?

A

Submucosa

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9
Q

Where is the Meissners plexus located in the stomach

A

Next to the inner circular layer of muscle in the Submucosa

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10
Q

What is the function of submucosal Meissners plexus

A

To influence the mucosa

I.E.- secretion, blood flow, any limited muscle contractions

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11
Q

What is the muscularis externa located in the stomach

A

Between cardiac region and greater curvature, all smooth muscle

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12
Q

What are the three layers of muscularis externa

A
  1. Innermost oblique- sometimes
  2. Middle circular- well developed
  3. Outer longitudinal- THIN

TQQQQQQQQ

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13
Q

Where is the myenteric (Auerbachs) plexus located in the stomach

A

Between the circular and longitudinal layers of muscle

Function is to stimulate the muscularis externa

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14
Q

Where is the serosa located in the stomach

A

THE ENTIRE STOMACH

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15
Q

THe cardiac region of the stomach is special because it

A

HAS NO CHIEF CELLS

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16
Q

What type of cells are in the cardiac region of stomach

A

Primarily surface mucous, some neck mucous, and few DNES and parietal cells

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17
Q

Where does the gastric region at

A

Gastric glands extend from gastric pit to MM

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18
Q

What cell produces intrinsic factor

A

Parietal

19
Q

What cell produces thick visible mucus

A

Surface mucus

20
Q

What cell produces pepsinogen

A

Chief

21
Q

What cell produces HCL

A

Parietal

22
Q

What cell produces gastrin

A

DNES

23
Q

What cell produces gastric lipase

A

Chief

24
Q

Which layer within the ME is not always present

A

Oblique

25
Q

What is the surface epithelium of the stomach

A

Simple columnar

26
Q

Isthmus cells produce what

A

Thick, visible mucus that traps bicarbonate ions. Alkaline

27
Q

What is the function of isthmus cells

A

To protect mucosa from auto-digestion and the rougher components of chyme

28
Q

What are DNES cells

A

Enteroendocrine cells

29
Q

What is a type D DNES cell do

A

Produces somatostatin, inhibits release of hormones by nearby DNES cells and HCL release

30
Q

Type EC DNES cells produce

A

Serotonin and substance P: increases gut motility

31
Q

What do type G DNES cells do

A

Produce gastrin, stimulates HCL and pepsinogen secretion, gastric motility, and regenerative cells in body of stomach

TQQQQQQQQQ

32
Q

What do neck cells do

A

Neck mucous cells- produce a soluble, less alkaline mucus. FUnction- to lubricate gastric contents

33
Q

What do regenerative cells do

A

Replace all cell types!

34
Q

What do parietal (oxyntic) cells do

A

Add odd columnar cells with intracellular canaliculi

Produce strong HCL, made a .8ph and buffer to 1-2ph

Intrinsic factor

35
Q

Intrinsic factor is necessary for

A

Vitamin B12 absorption

36
Q

What is chronic gastritis can lead to pernicious anemia

A

Low number of parietal cells can lead to low amounts of intrinisic factor which will decrease vitamin B12 absorption which is necessary for RBC maturation

37
Q

What chief cells produce

A

Pepsinogen to break down proteins

Some gastric lipase to break down fats

38
Q

What cells live at the Base of the stomach

A

Chief

Parietal

DNES

39
Q

What cells live at the neck

A

Neck mucus cells

Regenerative cells

Parietal

40
Q

What cells live at the isthmus

A

Surface mucous

DNES

41
Q

What cells are in the pyloric region of the stomach

A

Primarily surface mucus, DNES and parietal cells

Some neck mucous cells that also produce some lysozyme

42
Q

What is the pyloric sphincter

A

The anatomical sphincter between the pylorus of the stomach and the duodenum

43
Q

What are the characteristics of an anatomical sphincter

A
  1. Well developed inner circular layer of muscle in ME

2. Inner circular layer in ME can be independently controlled

44
Q

What are the two causes of peptic ulcer disease

A
  1. Damage to mucus coat
  2. Too much HCL and pepsin

Helicobacter pylori