Stomach Flashcards
What is the surface epithelium of the mucosa of the stomach
Simple columnar
What type of cells are found in the mucosa of the stomach
Surface
Regenerative cells
What is the function of surface mucous
Produce- thick visible mucus
Secrete- bicarbonate ions
what is the lamina propia like in the stomach
Loose, vascular CT, present in small amounts between glands
What is the muscularis mucosae of the mucosa in the stomach like
- Inner circular
- Outer longitudinal
- Outermost circular/ oblique
WELL DEVELOPED
What is the Submucosa of the stomach like
Highly vascular
Location of AVA= arteriovenous anastomosis TQ
What is the function of the AVA
To shut down activity and secretion FAST in the stomach
Where is the AVA found?
Submucosa
Where is the Meissners plexus located in the stomach
Next to the inner circular layer of muscle in the Submucosa
What is the function of submucosal Meissners plexus
To influence the mucosa
I.E.- secretion, blood flow, any limited muscle contractions
What is the muscularis externa located in the stomach
Between cardiac region and greater curvature, all smooth muscle
What are the three layers of muscularis externa
- Innermost oblique- sometimes
- Middle circular- well developed
- Outer longitudinal- THIN
TQQQQQQQQ
Where is the myenteric (Auerbachs) plexus located in the stomach
Between the circular and longitudinal layers of muscle
Function is to stimulate the muscularis externa
Where is the serosa located in the stomach
THE ENTIRE STOMACH
THe cardiac region of the stomach is special because it
HAS NO CHIEF CELLS
What type of cells are in the cardiac region of stomach
Primarily surface mucous, some neck mucous, and few DNES and parietal cells
Where does the gastric region at
Gastric glands extend from gastric pit to MM
What cell produces intrinsic factor
Parietal
What cell produces thick visible mucus
Surface mucus
What cell produces pepsinogen
Chief
What cell produces HCL
Parietal
What cell produces gastrin
DNES
What cell produces gastric lipase
Chief
Which layer within the ME is not always present
Oblique
What is the surface epithelium of the stomach
Simple columnar
Isthmus cells produce what
Thick, visible mucus that traps bicarbonate ions. Alkaline
What is the function of isthmus cells
To protect mucosa from auto-digestion and the rougher components of chyme
What are DNES cells
Enteroendocrine cells
What is a type D DNES cell do
Produces somatostatin, inhibits release of hormones by nearby DNES cells and HCL release
Type EC DNES cells produce
Serotonin and substance P: increases gut motility
What do type G DNES cells do
Produce gastrin, stimulates HCL and pepsinogen secretion, gastric motility, and regenerative cells in body of stomach
TQQQQQQQQQ
What do neck cells do
Neck mucous cells- produce a soluble, less alkaline mucus. FUnction- to lubricate gastric contents
What do regenerative cells do
Replace all cell types!
What do parietal (oxyntic) cells do
Add odd columnar cells with intracellular canaliculi
Produce strong HCL, made a .8ph and buffer to 1-2ph
Intrinsic factor
Intrinsic factor is necessary for
Vitamin B12 absorption
What is chronic gastritis can lead to pernicious anemia
Low number of parietal cells can lead to low amounts of intrinisic factor which will decrease vitamin B12 absorption which is necessary for RBC maturation
What chief cells produce
Pepsinogen to break down proteins
Some gastric lipase to break down fats
What cells live at the Base of the stomach
Chief
Parietal
DNES
What cells live at the neck
Neck mucus cells
Regenerative cells
Parietal
What cells live at the isthmus
Surface mucous
DNES
What cells are in the pyloric region of the stomach
Primarily surface mucus, DNES and parietal cells
Some neck mucous cells that also produce some lysozyme
What is the pyloric sphincter
The anatomical sphincter between the pylorus of the stomach and the duodenum
What are the characteristics of an anatomical sphincter
- Well developed inner circular layer of muscle in ME
2. Inner circular layer in ME can be independently controlled
What are the two causes of peptic ulcer disease
- Damage to mucus coat
- Too much HCL and pepsin
Helicobacter pylori