STIs

Question 17

What cause urethritis, cervicitis, and PID

Answer 17

chlamydia trachoma and neisseria gonorrhea

Question 18

describe the morphology and replication of neisseria gonorrhea

Answer 18

it is a diplococci

it is a facultative intracellular

Question 19

describe the morphology and replication of C. trachomatis

Answer 19

no peptidoglycan

obligate intracellular

Question 20

how many stages of syphilis are there

Answer 20

3

Question 21

What is the manifestation of primary syphilis

Answer 21

there is a chancre at the inoculation site and many bacteria

chancre is hard, firm, cartilaginous almost, it is raised AND it is painless

Question 22

What is the manifestation of secondary syphilis

Answer 22

• rash (on palms and feet soles)
• mucosal lesions
• lymphadenopathy
• fever

Many widespread bacteria

Question 23

What is the manifestation of tertiary syphilis

Answer 23

1. asymptomatic
2. latency
3. neurosyphilis
4. cardiovascular syphilis
5. gumma

widespread syphilis

Question 24

Diagnostic testing for syphilis

Answer 24

darkfield looks for spirochetes (greater thatn 95% sensitivity for looking at chancres)

Question 25

Characteristics of the non-treponemal test

Answer 25

It is not great for primary, but very sensitive for secondary and tertiary syphilis. This will wane with time

Question 26

characteristics of the treponemal test

Answer 26

this is positive for life. not very good at primary, but very good for secondary and tertiary

Question 27

What is a vector

Answer 27

It is an arthropod that transmits an infection

Question 28

What is a reservoir

Answer 28

a non-human host for the infection

Question 29

What is the species of Lyme Disease

Answer 29

B. burgdorferi

Question 30

What s characteristic of the localized B. burgdorferi infection

Answer 30

starts in days. An erythema migrans is found at a localized area of the skin. This is made by clinical diagnosis

Question 31

Disseminated B. burgdorferi

Answer 31

spreads over weeks. Found at the skin (multiple EM), CNS (meningitis and neuritis), and heart (arrythmia).

dx: ELISA or western.

Question 32

Persistent B. burgdorferi

Answer 32

Time-course = months. mostly swelling of single assymetrical joints (knees are common)

dx: Western or ELISA

Question 33

What is Rocky Mountain Spotted Fever

Answer 33

R. Ricketsii infection

Question 34

What is the tick for R. Ricketsii

Answer 34

Dermacentor tick

Question 35

What does R. Ricketsii infect and how does it do it

Answer 35

vascular endothelium. It does it by manipulating actin polymerization

Question 36

Give the flowchart of how this R. Ricketsii leads the way to dusky death

Answer 36

inflammation and endothelial damage–> increased permeability and coagulation –> thrombosis, hemorrhage, edema –> organ damage, shock

Question 37

Describe the presentation of R. Ricketsii

Answer 37

Onset: headache, myalgias

Rash: will come 2-6 days after exposure. starts with macule –> petechial rash. Includes palms and soles.

Organ damage: CNS, GI, Liver, Kidneys,

Question 38

Describe the presentation of ehrlichiosis

Answer 38

Fever, headache, myalgias

thrombocytopenia and leukopenia

obligate intracellular bacteria in the cells of the hematopoietic system

Question 39

What are the two species that make up ehrlichiosis

Answer 39

anaplasma phagocytophilum

ehrlichia chaffeensis

Question 40

What is the disease name and tick associated with anaplasma phagocytophilum

Answer 40

granulocytic anaplasmosis. The tick is ixodes

Question 41

What is the disease name and tick associated with ehrlichia chaffeensis

Answer 41

monocytic ehrlichiosis. tick is amblyomma americanum tick