Skin and Soft Tissue Infections Flashcards
what are the infections of staph aureus
impetigo, bullous impetigo & SSSS, folliculitis, carbuncle and furuncle
What are the infections of Strep pyogenes
impetigo, erysipelas, cellulitis, necrotizing fasciitis
what is the manifestation of toxic shock syndrome
high fever
hypotension with sunburn-like or maculopapular rash
palms and soles of feet desquamate
organ failure
How does TSS progress
there is subsequent desquamation of rash on palsm and soles of feet
What is the cause of it
Staph aureus is much more prevalent than strep pyogenes
What is the toxin name and what is it
It is called TSST-1 and it creates a massive T-cell response
what are the 3 types of botulinism
adult (foodborne), adult (wound), infantile
how does foodborne adult botulin enter and manifest
there is ingestion of the toxin that then leads to flaccid paralysis
how does the wound botulin enter and manifest
the bacterium get into the wound and then there is flaccid paralysis
How does botulism enter and manifest in an infant
The bacterium get into the GI tract and then actually will flourish. This leads to flaccid paralysis.
how does tetanus enter and manifest
the tetanus bacterium get into the wound and then cause rigid paralysis and autonomic dysfunction
How do the clostridial toxins work?
They are A-B toxins. The A domain are proteases that cleave neuronal molecules that are needed for synaptic vesicle fusion and neurotransmitter release
what do the botulism toxins do?
They will prevent acetylcholine release from motor neurons this causes reduced muscle contraction.
What do the tetanus toxins do?
the will prevent release of GABA, an inhibitory neuron. This leads to less inhibition of motor neurons and causes increased muscle contraction
What are the soft tissue infection that are definitely Staph aureus
bullous impetigo SSSS folliculitis carbuncle furuncle
