STIs

Question 1

3 symptoms of ghonorrhoea

Answer 1

urethritis, endocarditis, opthalmic D in newborn

Question 2

How do you diagnose ghonorrhoea

Answer 2

NAA test on urine, urethral swab / speculum exam

Question 3

How do you diagnose chlamydia

Answer 3

PCR, culture is gold standard, serology, antigen detection

Question 4

Describe the life cycle of chlamydia

Answer 4

Extracellular bodies are phagocytosed, reorganised into reticulate bodies, these then multiply and mature inside the cell (RB–> EB) before being released again

Question 5

Symptoms + causes of PID

Answer 5

abdo pain, fever, vag discharge. can be caused by chlamydia or ghonorrhoea

Question 6

Symptoms of classes of Syphilis

Answer 6

1y - ulcer and lymphadenopathy, 2y- skin lesions, meningitis, multisystem. Latent - neurosyphilis, CV, gummaton (can affect any organ)

Question 7

How would you diagnose syphilis

Answer 7

DFM microscopy, SEROLOY = treponemal - specific. non treponemal - not specific, EIA

Question 8

3 factors that increase the chances of HIV transmission

Answer 8

genital ulcers, STDs, high viral loads

Question 9

Name 4 antiretrovirals

Answer 9

NRTI, PI, NNRTI, fusion inhibitor

Question 10

UK first line treatment for AIDS

Answer 10

2 NRTI + 1 NNRTI

Question 11

Side effects of antiretrovirals

Answer 11

GI upset, rash, disturbed LFTs, mitochondrial toxicity,

Question 12

Which viral infection does ghonnorea amplify

Answer 12

hiv

Question 13

why is treating ghonorea not straightforward

Answer 13

resistant to penicilin, tetracycline, fluoquine

Question 14

what serotype of chlymida results in..

1) Oculogenital disease
2) cervicitis, Proctitis
3) Ocular trachoma

Answer 14

1. D-K
2. L1 L2 L3
3. A, B, Ba, C

Question 15

what can PID cause

what does it stand for

Answer 15

infertility

pelvic inflammatory disease

Question 16

two types of syphilis and how theyre classes

Answer 16

acquired - early had 2 years

congenital - early diagnosed 2

Question 17

how common is latent syphilis

Answer 17

30% get if left untreated

Question 18

chance of getting HIV from..
anal
vag
needle
breast feeding
peiperipatum
ceserian

Answer 18

1-3
0.3
0.3
20
10

Question 19

HIV and the lung, name some infections and neoplasms that are common

Answer 19

fungal infections, tb, bacteria e.g. pneumonia

kaposis sarcoma, lymphoma, Ca of the lung

Question 20

name some CNS symptoms common with HIV

Answer 20

headache - meningitis
cognition- AIDS demenita depression
conscious level - encephalitis, Toxoplasmosis, lymphoma
neuropathy - HIV VZV
myopathy - drugs
Myelopathy - vasculat myelopathy, cmv, zvz

Question 21

name 3 non infectious and 3 infectious cns lesions associated with HIV

Answer 21

1 - tumor, 1y CNS lymphoma, infarct

2- bacterial brain absess, tuberculoma, toxoplasmosis