stiner- oxygen transport Flashcards
The aqueous soln containing formed elements and lacks cells is
plasma
what is serum?
plasma faction without clotting factors
cellular fraction called what?
hematocrit (45%)
function of blood?
transport- oxygen, nutrients
distribution- nutrients, removes waste
some components involved in defense- plasma, serum
3 major cell components of blood
erythrocytes
leukocytes
thrombocytes
plasma function
- mainly water
- caries albumin, Carbon dioxide, hormones
RBC…derived? functoin
red bone marrow
carry oxygen, remove CO2
no organelles or nuclei
WBC function
protect the body by fighting diseases
platelets…derived from what? function
megakaryocytes
blood coagulation
plasma proteins 2 main catagories
- proteins synthesized by the liver
2. immunoglobins synthesized by bone marrow
which protein accounts for 50% of plasma proteins
albumin
albumin
highly polar
responsible for transporting hydrophobic fatty acids, bilirubin, and drugs
Transferrin
is a plasma glycoprotein that transports iron through the blood to the liver, spleen, and bone marrow.
Ferritin
is the major iron storage protein found in almost all cells of the body.
Hemosiderin
is a derivative of ferritin and is found in the liver, spleen, and bone marrow. It is insoluble in aqueous solutions, and forms aggregates that slowly release iron when deficiency occurs.
Ceruloplasmin
is the major transport protein for copper, an essential trace element.
IgA
is found widely in secretions and presents an antiseptic barrier, which protects mucosal surfaces
IgD
is a surface receptor for antigen in B lymphocytes
IgE
IgE is present only in trace amounts and acts to bind antigen and promote a release of vasoactive amines from mast cells
IgG
IgG is the most common immunoglobulin; freely crosses the placenta
IgM
IgM is confined to the intravascular space and helps eliminate circulating antigens and microorganisms
Measurement of _____ concentration in plasma is an essential test in diagnosis and monitoring of infection and sepsis
CRP
_______ transfer is essential for energy metabolism
Oxygen
Globins increase the ___________ of the otherwise poorly soluble hydrophobic heme group
aqueous solubility
complex found in heme
porphyin/iron complex
75% of iron attached to heme proteins in what state
Fe 2+
other 15% of iron is where?
stored in liver, spleen, bone marrow
stored formed of inron is what
ferritin, hemosiderin
iron predominately reabsorbed where?
in the duodenum
hemoglobin strucutre
Tetrahedral array of 2 identical a-globulins and 2 identical b-globulins
4 heme groups
