Steroids For Late Preterm Birth Flashcards
When was the Steroids for Late PTB Trial published?
2016
What were the inclusion criteria for the Steroids for Late PTB Trial?
Singleton pregnancy
34+0 - 36+5/40
High risk for delivery during the late preterm period
What were the exclusion criteria for the Steroids for Late PTB Trial
High probability of delivering within 12 hours
Rupture of membranes with more than 1:10 contractions or cervical dilation >3cm
Chorioamnionitis
Cervical dilatation > 8cm
Abnormal CTG
Previously received antenatal glucocorticoids
What were the two treatment arms of the Steroids for Late PTB Trial?
2 injections of betamethasone 24 hours apart
OR
2 injections of placebo 24 hours apart
Blinded
Randomised
What was the primary outcome in the Steroids for Late PTB Trial?
Neonatal composite of treatment in the first 72 hours (use of CPAP or high-flow nasal cannula, supplemental O2, ECMO or mechanical ventilation)
OR stillbirth / neonatal death within 72 hours of delivery
What were the two main findings of the Steroids for Late PTB Trial?
Primary outcome occurred less in the betamethasone group
- Betamethasone significantly reduced the rate of neonatal respiratory complications
Neonatal hypoglycaemia was more common in the betamethasone group
What was the effect of Steroids on Neonatal composite outcome in the first 72 hours?
Was it statistically significant?
Decreased
Betamethasone 11.6% and Placebo 14.4%
RR 0.80
Statistically significant
NNT = 35
What was the effect of Steroids on Severe respiratory complications?
Was it statistically significant?
Decreased with Betamethasone
Statistically significant
What was the effect of Steroids on Chorioamnionitis and neonatal sepsis?
Was it statistically significant?
No difference
What was the effect of Steroids on Neonatal hypoglycaemia?
Was it statistically significant?
Increased Betamethasone 24% Placebo 15% RR 1.6 Yes, statistically significant
How many women were recruited into the Steroids for Late PTB Trial?
2831 women
