HAPO

Question 1

What is the title of the HAPO Study?

Answer 1

Hyperglycaemia and Adverse Pregnancy Outcomes

Question 2

Who were the authors of HAPO?

Answer 2

HAPO Cooperative Research Group

Question 3

When, and in which journal was the HAPO Study published?

Answer 3

2008

NEJM

Question 4

What were the primary outcomes in the HAPO Study?

Answer 4

BW > 90th centile for gestational age
Primary CS delivery
Clinically diagnosed neonatal hypoglycaemia
Cord blood serum C-peptide level > 90th centile

Question 5

What were the secondary outcomes in the HAPO Study?

Answer 5

Delivery before 37/40
Shoulder dystocia or birth injury
Need for intensive neonatal care
Hyperbilirubinaemia
Preeclampsia

Question 6

What was the conclusion of the HAPO Study?

Answer 6

There are strong, continuous associations of maternal glucose levels below those diagnostic of diabetes with increased BW and increased cord-blood serum C-peptide levels

Question 7

What was the setting of the HAPO trial?

Answer 7

15 centres, 9 countries

2000-2006

Question 8

What the inclusion criteria for the HAPO trial?

Answer 8

All pregnant women at a given centre

Question 9

What were the exclusion criteria of the HAPO trial?

Answer 9

Age <18
Plan to undergo delivery at another hospital
Uncertain LMP and no USS between 6-24/40
Inability to complete OGTT within 32/40
Multiple pregnancy
Conception by OI or IVF
Glucose testing before recruitment
Diagnosis of DM during the current pregnancy and requiring treatment with medication
HIV, Hep B or C
Previous participation in HAPO
Participation in another study that could interfere with HAPO
Inability to converse in the languages used on centre forms without the aid of an interpreter

Question 10

How many women were recruited into the HAPO study?

Answer 10

25,505