ACHOIS Trial Flashcards
What is the title of the ACHOIS trial?
Effect of Treatment of Gestational Diabetes Mellitus on Pregnancy Outcomes
Who were the authors of the ACHOIS Trial?
Crowther, Hiller, Moss, McPhee, Jeffries
When, and in which journal was the ACHOIS Trial published?
2005
NEJM
What were the two groups in the ACHOIS Trial
Routine care vs
Dietary advice, BSL monitoring, insulin therapy as needed
What were the inclusion criteria for the ACHOIS Trial?
Between 24-34/40 Attended between 16-30/40 Attended ANC at the collaborating hospitals Diagnosis of GDM Singleton or twin pregnancy
What were the primary outcomes in the ACHOIS Trial?
Jaundice requiring phototherapy
IOL
CS birth
Serious perinatal complications (death, shoulder dystocia, bone fracture, nerve palsy)
Admission to the neonatal nursery
Maternal anxiety, depression and health status
In the intervention group of the ACHOIS trial, what was the impact on serious perinatal complications?
Significantly lower rate
1% vs 4%
NNT 34
In the intervention group of the ACHOIS trial, what was the impact on admission to neonatal nursery?
Increased
RR 1.15
In the intervention group of the ACHOIS trial, what was the impact on IOL?
Increased rate of IOL
RR 1.31
In the intervention group of the ACHOIS trial, what was the impact on CS rate?
Similar CS rate
In the intervention group of the ACHOIS trial, what was the impact on rates of depression?
Lower rates of depression
In the intervention group of the ACHOIS trial, what was the impact on rate of shoulder dystocia?
No change
In the intervention group of the ACHOIS trial, what was the impact on mean birth weights, LGA and macrosomia
All reduced, and statistically significant
In the intervention group of the ACHOIS trial, what was the impact on the number of women diagnosed with PET?
Fewer
What was the conclusion of the ACHOIS Trial?
Treatment of GDM reduces serious perinatal mortality and may also improve the woman’s health-related quality of life
