Steroids

Question 1

Prednisolone sodium succinate

Answer 1

fast-acting steroid, inject IV or IM + oral formulations

Question 2

dexamethasone

Answer 2

fast acting, IV, IM, oral

Question 3

methylprednisolone acetate

Answer 3

slow absorption, long-acting steroid IM/SC/intra-articular

Question 4

prednisolone acetate

Answer 4

slow absorption, IM/SC/intra-articular

Question 5

isoflupredone acetate

Answer 5

cattle, horses, pigs. some mineralocorticoid effect
- side effect: hypokalemia with repeated doses
IM/SC/intra-articular

Question 6

glucocorticoids

Answer 6

high volume of distribution must be metabolized to its active form

Question 7

glucocorticoid effects on HPA axis

Answer 7

steroids suppress the hypothalamo-pituitary adrenal axis

- important for weaning patient off steroids

Question 8

glucocorticoid biological effect

Answer 8

increase blood glucose, increase gluconeogenesis

Question 9

glucocorticoid immune effect

Answer 9

reduce inflammation at low-moderate dose
suppress immune system at high doses
stress leukogram

Question 10

what enzyme does glucocorticoids inhibit?

Answer 10

phopholipase C

Question 11

adverse effects of glucocorticoids

Answer 11

hyperadrenocorticism, hyperglycemia, diabetes in cats , delayed wound healing, muscle atrophy