Steroid pharmacology - french

Question 1

Cortisol has both mineralocorticoid and glucocorticoid effects (50/50). It is the natural endogenous glucocorticoid. What is another name for it?

Answer 1

Hydrocortisone

Question 2

What are three pharmacologic glucocorticoids?

Answer 2

Prednisone, triamcinolone, dexamethasone

Question 3

Rate the relative potencies of cortisol (hydrocortisone), prednisone, triamcinolone, dexamethasone in terms of salt retention effect (greatest to least)

Answer 3

Cortisol > prednisone > triamcinolone = dexamethasone = 0

Question 4

Rate the relative potencies of cortisol (hydrocortisone), prednisone, triamcinolone, dexamethasone in terms of anti-inflammatory potency (greatest to least)

Answer 4

Dexamethasone&raquo_space;> triamcinolone > prednisone > cortisol

Question 5

Rate the duration of action of cortisol (hydrocortisone), prednisone, triamcinolone, dexamethasone (greatest to least)

Answer 5

Dexamethasone > prednisone = triamcinolone > cortisol

Dex = 24-36
cortisol = 8-12
prednisone = 12-24
triamciclone = 15-24

Question 6

What is the ratio between the mineralocorticoid effect of aldosterone vs. cortisol (Na retention)?

Answer 6

3000:1

Question 7

What is the pharmaceutical mineralocorticoid mentioned in the notes?

Answer 7

Fludrocortisone

Question 8

What is the Na retention effect of fludrocortisone relative to cortisol?

Answer 8

125-250:1 (Aldosterone is 3000)

Question 9

Which two corticosteroids must be converted from an 11-ketoglucocorticoid to an 11-hydroxycorticoid (the active form)? Name the inactive and inactive forms of each. There are two.

Answer 9

Cortisone—->Cortisol

Prednisone–>Prednisolone