Pituitary Pharmacology - French

Question 1

Drugs for growth hormone deficiency

Answer 1

Somatotropin - GH analog
Mecasermin - (IGF-1 recombinant analog for Laron's)
GHRH analogs (not bold)

Question 2

Drugs for growth hormone excess

Answer 2

Octreotide, Lanreotide (somatostatin analogs)

[Cabergoline, Bromocriptine (Dopamine agonists)
Pegvisomant (GH receptor antagonist)]

*Acromegaly is treated with Cabegoline due to oral administration

Question 3

Drugs for hyperprolactinemia

Answer 3

Cabergoline, Bromocriptine (Dopamine agonists)

Question 4

Drugs for central diabetes insipidus

Answer 4

Chlorpropamide, Desmopressin (ADH analogs)

Question 5

Drugs for Nephrogenic diabetes insipidus

Answer 5

Hydrochlorothiazide (THiazide diuretics)

Indomethacin (NSAID)

Question 6

Drugs for SIADH

Answer 6

Demeclocycline (inhibits ADH effect on distal tubule)

Tolvaptan, Conivaptan (ADH V2 receptor antagonists)

Question 7

Drugs inducing DI

Answer 7

Lithium, demeclocycline

Question 8

Drugs inducing SIADH

Answer 8

SSRIs, haloperidol, TCADs

Question 9

Somatotropin

Answer 9

GH analog

Question 10

Mecasermin

Answer 10

(IGF-1 recombinant analog for Laron’s)

Question 11

Octreotide

Answer 11

Somatostatin analog

Question 12

Lanreotide

Answer 12

Somatostatin analog

Question 13

Cabergoline

Answer 13

Dopamine agonist

Question 14

Bromocriptine

Answer 14

Dopamine agonist

Question 15

Pegvisomant

Answer 15

GH receptor antagonist

is a mutated GH molecule with polymers attached to extend its half-life. Binds to receptor, blocking GH access, but does activate signaling transduction. Single daily dose administered subcutaneously.

Question 16

Chlorpropamide

Answer 16

ADH analog

Question 17

Desmopressin

Answer 17

ADH analog

Question 18

HCTZ

Answer 18

Drug for nephrogenic DI (diuretic). THis is a paradoxical response, not known why HCTZ has the exact opposite effect of usual in patients with nephrogenic DI.

Question 19

Indomethacin

Answer 19

Drug for nephrogenic DI (NSAID). INhibition of prostaglandins causes less filtration and blocks the DI (hypothetical).

Question 20

Demeclocycline

Answer 20

Drug for SIADH (inhibits ADH effect on distal tubule)

Question 21

Tolvaptan

Answer 21

Drug for SIADH (ADH V2 receptor antagonists)

Question 22

Conivaptan

Answer 22

Drug for SIADH (ADH V2 receptor antagonists)

Question 23

Lithium

Answer 23

Induces DI

Question 24

Demeclocycline

Answer 24

Treats SIADH by blocking action of ADH

Induces DI

Question 25

SSRI

Answer 25

Induces SIADH

Question 26

Haloperidol

Answer 26

Induces SIADH

Question 27

TCAD

Answer 27

induces SIADH