Hormones mini deck - Eriksen

Question 1

Name the # of carbons in estrogens

Answer 1

18

Question 2

Name the # of carbons in androgens

Answer 2

19

Question 3

Name the # of carbons in progestins

Answer 3

21

Question 4

Name the # of carbons in glucocorticoids (cortisol) and mineralocorticoids (Aldosterone)

Answer 4

21

Question 5

Cholesterol has how many carbons?

Answer 5

27. All derived from acetyl CoA

Question 6

What is the initial and rate-limiting step in hormone synthesis (with cholesterol as a starting product) that results in the pregenelone precursor?

Answer 6

20, 22 desmolase. This is a rate-limiting enzyme in the mitochondrial membrane.

AKA cholesterol desmolase

Question 7

Leydig cell:_____::Sertoli:Granulosa

Notable characteristics

Answer 7

Leydig/Theca

LH receptors (produce)
Make androgens
Cannot make estrogens (no aromatase)

Mnemonic: Leydig = Lh = Lack aromatase

Question 8

Leydig/Theca cells are more concerned with____.

Sertoli/Granulosa are more concerned with ____.

Answer 8

Leydig/Theca = hormone production
Sertoli/Granulosa = nurse cells (direct contact w/sex cells)

Question 9

Leydig cell:Theca::_____:Granulosa

Notable characteristics

Answer 9

Sertoli/Granulosa.

FSH receptors
Make Inhibin
Convert androgens to estrogens via aromatase.

Mnemonic: Sertoli = fSh = Sperm

Question 10

DHEA comes from the ____

Answer 10

adrenal

Question 11

Androstenedione comes from the ___.

Answer 11

gonads

Question 12

___ is the most potent androgen but it doesn’t

really circulate. It remains in the peripheral tissues.

Answer 12

Dihydrotestosterone

Question 13

E1 is made in the?

Answer 13

Adipose.

One–> Round, like fat people.

Question 14

E2 is made in the?

Answer 14

Ovaries. E2, 2 ovaries.

Question 15

E3 is made in the?

Answer 15

placenta. E3–> 3 trimesters

Question 16

Can the gonads make cholesterol?

Answer 16

Yes.

Question 17

What are the extragonadal sources of sex steroids?

Answer 17

Fat and adrenals.