STEP 2 - UWORLD part 2 Flashcards
normally aldo does what
acts on the DCT/CD to reabsorb Na and secrete K/H into urine
common infections in cushings
nocardia, PCP, fungal
primary vs secondary hyperparathyroidism
primary - hypercalcemia
secondary - hypocalcemia
MC presentation of hyperparathyoidism
asymptomatic hypercalcemia
MCC of secondary hyperparathyroidism
CKD
increased phos, low ca, low vitamin d
tertiary hyperparathyroidism
how to stimulate PTH normally
if you have elevated phos, low ca, and low calcitriol
CKD and increased PTH
restrict dietary phos, Ca based phos binder, vitamin D
labs in primary hyperparathyroidism
increased Ca and hypercalciuria
increased or NL PTH
hypophosphatemia
multifocal subperiostal bone reabsorption in distal phalanges on radiograph
primary hyperparathyroidism
> 50000 WBC on joint tap
septic joint
cloudy jiont tap, >2000WBC, 50% PMNs and +/- crystals
inflammed joint
antismooth muscle antibody
Lupus
11 things you need to have lupus (only need 4 of them)
Malar
Discoid
Serositis
Oral ulcer
Arthritis
Photosensitivity
Blood decreaed Hgb and pH Renal failure ANA+ Immunologic Neuro
decreased C3/C4 in someone with a malar rash and fever
SLE
SLE tx
hydroxychloroquine
steroids during a flare
IV cyclophosphomide at beginning of nephritis
mycophenelate for nephritis after
MCC of drug indiced SLE
hydralazine
dsDNA
lupus nephritis
do you need to bx a suspected lupus nephritis
yes
first test for lupus
ANA
what joints does RA go for
RAlly small ones but never DIP
Arthritis that covers >3 joints, spares the DIP joints, morning stiffness lasts for >60 mins
RA
cholesterol nodules on fingers
RA
periarticular osteopenia on radiograph
RA
alternatives to MTX in RA
leflunimide unless pregnant then hydroxychloroquine
RA + splenomegaly + neutropenia
Felty’s
hands and face are tight, pt has GERDq
CREST (limited scleroderma)
tight face + GERD + constrictive pericarditis + renal problems
diffuse scleroderma
treatment for calcinosis and raynauds parts of CREST
CCBs
treatment for esophageal part of CREST
PPI
treatment for sclerodactyly part of CREST
penicillamine
never give what in renal crisis in scleroderma
steroids!
anticentromere
CREST
antiscl70/topoisomerase
sceleroderma
dry eyes, dry mouth (cavities), parotid swelling
sjogrens
Ro/La
sjogrens (check ANA/RF first)
myosities types
inclusion body - t-cell
polymyositis - t-cell
dermatomyositis - complex deposition
heliotrope rash
gottron’s papules
shawl sign
myosities
increased CK, EMG positive
myosities - bx will show which one
Anti Mi/Anti Jo
myosities
tx for renal problems in scleroderma
ACE
tx for poly/dermatomyositis
steroids
positive birefringeance with rhomboid shaped crystals
pseudogout
negative birefringeance with needle shaped crystals
gout
use which drugs in gout/pseudogout flare/prophylaxis
cochicine (unless CKD)
NSAIDs (unless bleeding)
steroids (if the other two are contraindicated)
when is probenicid used
when a person has gout and NO risk factors
prevent tumor lysis
IVF + allopurinol
fix tumor lysis
rasburicase
keep uric acid below what in gout
<6
Septic knee, suspect MSSA vs MRSA
nafcillin vs vanc/linezolid
shock with decreased breath sounds and trach deviation
hemothorax
hyperprolatinemia can also give what s/e in antipsychotics
sexual dys
unilateral cavernous hemangioma on trigeminal nerve and tramline intercranial calcifications with seizures
sturge-weber
depression symptoms within 3 months of a life change (school starts, breakup, move)
adjustment disorder
treatment for adjustment disorder
psychotherapy
diagnose lichen sclerosis
punch bx
treatment for lichen scleorisis
topical corticosteroid - clobestol
pH of BV
5-6.5
thin, loose skin, thin umbilical cord, wide anterior fontanelle, also meconium staining
fetal growth restriction
mouth blisters with large flaccid bullous lesions
pemphigus vulgaris - vulgar flaccid lesions
pemphigus vulgaris - which abs
autoantibodies against desmoglein
tx for polymyalgia rheumatica
steroids - no other diagnostic step is necessary
when is supplemetnal iron needed in an infant
prematurity
materal iron def
cows milk before 1 year
all exclusively breast fed infants need what supplemented
vitamin D
increased alk phos out of proportion to LFTs
biliary obs or intrahepatic cholestasis
conjugated bili increase + increased alk phos + painless jaundice + weight loss
cholangiocarcinoma or pancreatic carcinoma
hypovolemia (renin and Na)
renin increases and urine sodium decreases becuase the body is trying to hold onto water so it also holds Na
low volume bloody diarrhea with low fever in HIV pt with CD4 ct <5
CMV
microsporidium vs cryptosporidium in HIV
micro - watery diarrhea without fever
crypto - severe watery diarrhea with low fever
treat >1cm or symptomatic prolactinoma with what
dopamine agonists - cabergoline
acyclovir IV can cause what if not pretreated
crystaline nephropathy if not hydrated
decreased LV preload, CO, systemic BP
increaed HR
CVP and PCWP are decreaesd because of intravascular blood volume
hypovolemic shock
tx for tertiary hyperparathyroidism
remove the parathyroids
labs seen in cushings
hypoK, hypercalciuria, met alk
HLA in hashimotos
HLADR3/5
which imagining helps diagnose primary hyperaldo
adrenal CT
adrenal CT helps distinguish what in primary hyperaldo
Conn (adenoma) and idopathic
are germinal centers normal in thyroid tissue
no, this is graves disease
pale colloid with scalloped edges in the thyroid
graves disease
toxic strains of cholera
01 and 0139
hypotension , salt wasting, and ambiguous female genitalia at birth
21-OH CAH
Hurthle cells are associated with what
Hashimotos thyroiditis
deeply eosinophilic tissue in thyroid
Hurthle cell metaplasia from hashimotos
MC heart problem in cushings
diastolic failure
MC drug used in cushings to treat symptoms
ketoconazole (blocks steroid synthesis)
secondary adrenal insufficiency presents with
profound hypoglycemia and low testosterone
in exogenous thyroid hormone use what will happen to RAUI scan
decreased uptake
nodular lymphatic growth pattern without normal germinal centers
NHL
hyperthyroid treatment in pregnancy
PTU in first trimester, Methimazole thereafter
congenital, extravascular, Coombs-negative hemolytic anemia should also be tested for
pyruvate kinase deficiency
RPGN with anti GBM abs
type 1
RPGN with immune complex abs
type 2
RPGN with no immune complex deposition
type 3
type of RPGN of goodpastures syndrome
type 1
type of RPGN involved in PSGN, lupus nephritis, HSP or IgA nephropathy
type 2
type of RPGN in wegners granulomatosis or microscopic polyangitis
type 3
elevated labs in AIN
eosinophilia and creatinine
what is seen in the CSF of AIDS dementia
B2 microglobulin
pt with rbc casts, increased ESR/CRP and positive C-ANCA
Wegners granulomatosis (granulomatosis with polyangitis)
Pleural fluid protein / serum protein ratio of 0.3, pleural fluid LDH / serum LDH ratio of 0.5, and a pleural fluid LDH of 150 U/L would indicate what etiology in a pt with new onset SOB, and orthopnea
CHF
pt with tremors and confusion, low blood glucose (<50), and is at normal baseline when glucose is normal - triad?
whipples triad
increased insulin with decreased c-peptide
serreptitous hypoglycemia - theyre faking it
Non-suppression of serum insulin levels in the setting of hypoglycemia
insulin secreting tumor
Whipple’s triad suggests what etiology of hypoglycemia
insulinoma
if pt cannot have surgical removal of insulinoma - treatment?
diazoxazide
elevated c-peptide in someone with hypoglycemia
sulfonyurea tox or insulinoma
what syndrome are insulinomas assoc with
MEN1
treatment for hypoglycemia from sulfonyurea OD
octreotide
hypopartahytoidism results in what defi
hypocalcemia
hypocalcemia, hyperphosphatemia and low serum PTH
hypoparathyroidism
> 6/<1mg mag can impair what hormone
PTH
somatostatin inhibits what
GH
which hormone conserves water
ADH by increasing water reabsorption at the collecting duct
MEN2a and 2b ALWAYS get what
medullary thyroid ca
PTH is secreted in response to
hypocalcemia
what effect does calciton have
tones down the calcium - opposes PTH by inhibiting bone reabsorption
PTH function in the kidneys
increase DCT reabsorption of Ca to increase serum calcium levels
increase Vitmain D
decrease phosphate reabsorption
stimulates bones to produce RANK-L and G-CSF which causes osteoclast proliferation
PTH
which hormone regulates T4 levels
TBG
which tyroid casues short lived metabolic effects
T3, shorter half life
woman <40 with unpalpable pulses
takayasus
antibodies to desmoglein (desmosomes) and nikolsky + and ruptures easily
pemphigus vulgaris - vulgar, it’s life threatning, there’s blisters in the mouth and is super gross
bx of blister showing thin walled blister with cells askew and IF throughout the whole slide
pemphigus vulgaris
treatment for vulgaris
steroids
round blisters in older person with -nikosky sign with no mouth lesions
pemphigoid (O for ROUND blisters)