Step 1 immunology pharm

Question 1

Cyclosporin

Answer 1

MOA: inhibits caclcineurin, prevents IL-2 release, inhibiting T cells.

Question 2

Tacrolimus

Answer 2

MOA: binds FK binding protein, inhibits calcineurin and secreiton of IL-2. decreases T lymphocytes

Question 3

sirolimus

Answer 3

MOA: inhibits mTOR (mammillian target of rapamyacin), inhibits T-proliferation to IL-2

Question 4

What do you give post kidney transplant

Answer 4

CSS, Cyclosporin, sirolimus, Steroids (cortico)

Question 5

Azathioprine

Answer 5

MOA: precurosor of 6-mercaptopurine. interferes with NA metabolism. Toxic to lymphocytes

Question 6

Muromonab

Answer 6

monoclonal antibody to CD3 on T cells. Blocks T-cell signal transduction

Question 7

antibody target and use: digoxin immune Fab

Answer 7

Digoxin

Question 8

antibody target and use: Infliximab

Answer 8

TNF-a

Question 9

antibody target and use: Adilimumab

Answer 9

TNF-a

Question 10

antibody target and use: abciximab

Answer 10

Tlycoprotein IIb/IIIA

Question 11

antibody target and use: trastuzumab

Answer 11

HER2

Question 12

antibody target and use: Rituximab

Answer 12

CD20

Question 13

antibody target and use: omalizumab

Answer 13

IgE

Question 14

recombinant agent and use: aldesleukin

Answer 14

IL-2

Question 15

recombinant agent and use: filgrastim

Answer 15

Granulocyte colony stimulating factor

Question 16

recombinant agent and use: sargramostim

Answer 16

GCSF

Question 17

recombinant agent and use: IFN-a

Answer 17

HBV,HCV, kaposis sarcoma, leukemia, malignant melanoma

Question 18

recombinant agent and use: IFN-b

Answer 18

MS

Question 19

recombinant agent and use: IFN-g

Answer 19

chronic granulomatous disease

Question 20

recombinant agent and use: oprelvekin

Answer 20

IL-11

Question 21

Daclizumab?

Answer 21

Blocks IL-2 receptor