Step 1 ANS drugs Flashcards

1
Q

bethanechol uses

A

postoperative/neurogenic ileus, urinary retention

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2
Q

bethanechol mechanism

A

cholinomimetic

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3
Q

carbachol uses

A

glaucoma, pupillary contraction, IOP relief

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4
Q

carbachol mechanism

A

direct cholinomimetic

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5
Q

pilocarpine mechanism

A

direct cholinomimetic

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6
Q

pilocarpine uses

A

glaucoma (in emergencies, especially narrow angle), potent stimulator of sweat, tears, saliva

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7
Q

methacholine mechanism

A

direct cholinomimetic

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8
Q

methacholine use

A

challenge test for asthma

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9
Q

neostigime mechanism

A

cholinesterase inhibitor

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10
Q

neostigime uses

A

myasthenia gravis, postoperative blockade reversal, urinary retention

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11
Q

pyridostigime mechanism

A

cholinesterase inhibitor

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12
Q

pyridostigmine uses

A

myasthenia gravis (doesn’t penetrate CNS)

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13
Q

edrophonium mechanism

A

cholinesterase inhibitor

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14
Q

edrophonium use

A

short acting, diagnosis of MG

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15
Q

physostigime uses

A

glaucoma, atropine overdose

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16
Q

physostimine mechanism

A

cholinesterase inhibitor

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17
Q

echothiophate mechanism

A

cholinesterase inhibitor

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18
Q

echolthiophate use

A

glaucoma

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19
Q

cholinomimetic toxicity

A

brochospasm (exacerbate COPD, asthma), peptic ulcers

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20
Q

antidote to cholinesterase poisoning

A

atropine and pralidoxime

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21
Q

tropicamide use

A

eye dilation

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22
Q

muscarinic antagonists

A

atropine, homatropine, tropicamide, scopolamine, ipratropium, oxybutynin, glycopurrolate, methscopolamine, pirenzepine, propantheline

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23
Q

scopolamine use

A

motion sickness

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24
Q

ipratropium use

A

asthma, COPD

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25
oyxbutinin use
reduce urgency in cystitis; reduce bladder spasms
26
methscopolamine, pirenzepine use
peptic ulcer treatment (reduces secretions)
27
atropine toxicity
dry as a bone, hot as hair, blind as a bat, red as a beet, mad as a hatter, can cause acute angle closure glaucoma, urinary retention in med with BPH, hyperthermia in infants (sympathetic and blocks sweat glands)
28
hexamethonium mechanism
nicotinic antagonist
29
hexamethonium use
experimental (ganglion blocker--prevents reflex bradycardia)
30
hexamethonium toxicity
severe orthostatic hypotension, blurred vision, constipation, sexual dysfunction
31
pancuronium, tubocurarine mechanism
nictotinic antagonists
32
epinephrine mechanism
sympathetomimetic (beta more than alpha)
33
epinephrine uses
cardiac arrest, anaphylasis, glaucoma (not narrow angle), hypotention
34
norepinephrine mechanism
sympathetomimetic. (alpha more than beta)
35
norepinephrine uses
hypotension (but decreases renal perfusion)
36
isoproterenol mechanism
sympathetomimetic (beta only)
37
isoproternol uses
rarely for AV block
38
dopamine mechanism
sympathomimetic (dopamine receptors most, then beta then alpha), at high levels, inotropic and chronotropic
39
dopamine uses
shock (increases renal perfusion), heart failure
40
dobutamine
sympathetomimetic (beta1 more than beta 2); inotropic but not chronotropic
41
dobutamine uses
heart failure, cardiac stress testing
42
phenylephrine mechanism
sympathetomimetic; alpha selective (alpha 1 more than alpha 2)
43
phenylephrine uses
pupillary dilation, vasoconstriction, nasal decongestion
44
metaproterenol mechanism
sympathetomimetic, selective beta 2
45
albuterol mechanism
selective beta 2 agonist
46
metaproterenol use
asthma (acute)
47
albuterol use
asthma (acute)
48
salmeterol mechanism
selective beta 2 agonist
49
salmeterol use
long term asthma treatment
50
terbutaline mechanism
selective beta 2 agonist
51
terbutaline use
reduce premature uterine contractions
52
ritodrine mechanism
beta 2 agonist
53
ritodrine use
reduce premature uterine contractions
54
amphetamine mechanism
indirect sympathetomimetic, releases stored catecholamines
55
amphetamine uses
narcolepsy, obesity, ADD
56
ephedrine mechanism
indirects sympathetomimetic, releases stored catecholamines
57
ephedrine use
nasal decongestio, urinary incontinence, hypotension
58
cocaine mechanism
NE reuptake inhibitor
59
cocaine use
vasoconstriction and local anesthesia
60
clonidine mechanism
alpha 2 agonist, decrease adrenergic outflow
61
clonidine uses
hypertension, especially in renal disease because doesn't decrease flow to kidney
62
alpha methyldopa mechanism
central alpha 2 agonist, decreases adrenergic outflow
63
methyldopa use
hypertension, especially in pregnancy
64
phenoyxbenzamine mechanism
irreversible alpha blocker
65
phentolamine mechanism
reversible alpha blocker
66
phentolamine and phenoxybenzamine uses
pheochromocytoma before surgery
67
phenoxybenzamine, phentolamine toxicity
orthostatic hypotension, reflex tachycardia
68
prazosin, terazosin, doxazosin mechanism
alpha 1 selective blockers
69
zosin uses
hypertension, urinary retention in BPH
70
zosin toxicity
1st dose orthostatic hypertension. dizziness, headache
71
mirtazapine mechanism
selective alpha 2 blocker
72
mirtazapine use
depression
73
mirtazapine toxicity
increase appetite, serum cholesterol; sedation
74
non-selective beta blockers
propanolol, timolol, nadolol, pindolol
75
selective beta 1 blockers
acebutolol, betaxolol, esmolol, atenolol, metoprolol
76
nonselective alpha and beta blockers
carvedilol, labetalol
77
partial beta agonists
pindolol, acebutolol
78
beta blocker toxicity
impotence, asthma exacerbation, bradycardia, AV block, CHF, sedation, sleep alterations
79
propanolol additions effect
decreases peripheral conversion of T4 to T3