Steotic Liver Disease Flashcards
Fat accumulation in the form of TGs within the liver
MASLD
A fat accumulation of >___% of the weight of the liver is needed for diagnosis
5
What are 2 risk factors for MASLD?
- Obesity
- Insulin resistance
The progression of MASH generally occurs when?
Over time if lifestyle modification is ineffective
MASH and MASLD combined are now the ____ cause of liver disease
1
What drug class is used to manage MASLD/MASH?
Statins
What 2 drugs are used to treat MASLD/MASH?
- Atorvastatin
- Pravastatin
What lifestyle modification can be utilized to manage MASLD/MASH?
Weight loss of 10%
What are the 2 types of drug induced liver disease?
- Intrinsic
- Idiopathic
What type of drug induced liver disease is dose dependent?
Intrinsic
What type of drug induced liver disease is usually caused by an allergic reaction?
Idiopathic
What 3 physical findings are used for a diagnosis of exclusion?
- Rash
- Fever
- Signs of chronic liver disease
What is the most common cause of drug induced liver injury?
Acetaminophen
What does acetaminophen have a direct toxic effect on?
Hepatocytes
What metabolite is the hepatotoxic metabolite?
NAPQI