Steotic Liver Disease Flashcards

1
Q

Fat accumulation in the form of TGs within the liver

A

MASLD

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2
Q

A fat accumulation of >___% of the weight of the liver is needed for diagnosis

A

5

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3
Q

What are 2 risk factors for MASLD?

A
  1. Obesity
  2. Insulin resistance
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4
Q

The progression of MASH generally occurs when?

A

Over time if lifestyle modification is ineffective

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5
Q

MASH and MASLD combined are now the ____ cause of liver disease

A

1

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6
Q

What drug class is used to manage MASLD/MASH?

A

Statins

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7
Q

What 2 drugs are used to treat MASLD/MASH?

A
  1. Atorvastatin
  2. Pravastatin
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8
Q

What lifestyle modification can be utilized to manage MASLD/MASH?

A

Weight loss of 10%

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9
Q

What are the 2 types of drug induced liver disease?

A
  1. Intrinsic
  2. Idiopathic
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10
Q

What type of drug induced liver disease is dose dependent?

A

Intrinsic

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11
Q

What type of drug induced liver disease is usually caused by an allergic reaction?

A

Idiopathic

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12
Q

What 3 physical findings are used for a diagnosis of exclusion?

A
  1. Rash
  2. Fever
  3. Signs of chronic liver disease
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13
Q

What is the most common cause of drug induced liver injury?

A

Acetaminophen

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14
Q

What does acetaminophen have a direct toxic effect on?

A

Hepatocytes

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15
Q

What metabolite is the hepatotoxic metabolite?

A

NAPQI

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16
Q

What is the antidote for a Tylenol overdose?

A

N-acetylcysteine

17
Q

What 4 drugs are considered Idiopathic?

A
  1. Augmentin
  2. NSAIDs
  3. Phenytoin
  4. Nitrofurantoin
18
Q

What 4 drugs are considered intrinsic?

A
  1. Isoniazid
  2. Valproate
  3. Azothioprine
  4. Amiodarone
19
Q

What organ does amiodarone not effect?

A

Kidneys

20
Q

What drug class is 2nd to Tylenol in drug related hepatotoxicity?

A

Herbals and dietary supplements

21
Q

What are anabolic steroids associated with?

A

Prolonged jaundice

22
Q

Inherited disorder due to high rates of blood transfusions

A

Hemochromatosis

23
Q

When is hemochromatosis asymptomatic until?

A

90% of the liver has iron deposition

24
Q

What 2 ways can you manage hemochromatosis?

A
  1. Weekly phlebotomy
  2. In sickle cell disease: iron chelation therapy
25
Q

What metal accumulates with Wilson’s disease?

A

Copper

26
Q

What is a sign of Wilson’s disease?

A

Kayser-Fleischer rings

27
Q

How would you treat Wilson’s disease?

A
  1. Copper chelation therapy
  2. Penicillamine or trientine
28
Q

Fulminant liver failure has an acute onset of _______ and impaired ________?

A

Encephalopathy; synthetic function

29
Q

What is the most common precipitating factor of fulminant liver failure?

A

APAP Toxicity

30
Q

What is fulminant liver failure not usually caused by?

A

Alcohol

31
Q

How would you treat fulminant liver failure?

A

Remove the offending cause

32
Q

What is listing on the transplant list dependent on?

A

MELD score

33
Q

What are 2 contraindications for a liver transplant?

A
  1. Life threatening systemic disease
  2. Active drug and alcohol abuse
34
Q

What are 4 relative contraindications for a liver transplant?

A
  1. HIV
  2. > 70
  3. Portal vein thrombosis
  4. Severe hypoxia
35
Q

If you get a liver from a living donor, what part of the liver is donated?

A

Left lobe