Stem Cells Flashcards
1
Q
What does the inner cell mass (ICM) differentiate into?
A
Endoderm
Mesoderm
Ectoderm
2
Q
At what day(s) is the embryo then considered a blastocyst?
A
Day 5-6
3
Q
Can cells reverse to a pluripotent stem cell after differentiation?
A
Yes! Called induced pluripotent stem cells (iPs)
4
Q
What do megakaryocytes produce?
A
Platelets
5
Q
How do megakaryocytes generate platelets?
A
SDF1 and FGF4 chemokines promote megakaryocyte adhesion
Endothelial cells are sinusoidal: Proplatelets are extended into the vasculature through gaps
Shear forces cause the distal tip of the proplatelet to bleb off into circulation -> fully realized platelet
6
Q
The poorer a country is, the _____ likely people are to donate blood.
A
LESS
7
Q
High F leads to _____ severe sickle cell disease
A
less severe
