Cell Cycle

Question 1

What adult cell types do not divide?

Answer 1

Nerve cells

Striated muscle

Question 2

What happens in the G2 phase of the cell cycle?

Answer 2

Preparation for cell division

Question 3

What happens in the G1 phase of the cell cycle?

Answer 3

Growth and metabolism

Question 4

What is the order of the cell cycle after mitosis?

Answer 4

G0 -> G1 -> S -> G2 -> M

Question 5

What happens in prophase/prometaphase?

Answer 5

Chromosomes appear as two thin threads

Microtubules attach at centromere

Question 6

Which cell cycle phases does cyclin A cover?

Answer 6

S and G2

Question 7

Which cell cycle phases does cyclin B cover?

Answer 7

G2 and M

Question 8

Which cell cycle phases does cyclin D cover?

Answer 8

G1 into S

Question 9

Which cell cycle phases does cyclin E cover?

Answer 9

Mostly S

Question 10

Which cyclins does Cdk2 bind?

Answer 10

E or A

Question 11

Which cyclins do Cdk4 and Cdk6 bind?

Answer 11

D

Question 12

Which cyclin does Cdc2 bind?

Answer 12

B

Question 13

What can inhibit the cyclin-Cdk complexes?

Answer 13

CKI - Cycling Kinase Inhibitor

Question 14

Elevated ____ can inhibit cell cycle progression, while elevated ____ promote the cell cycle

Answer 14

CKI inhibits

Cyclins promote

Question 15

What does p27 do?

Answer 15

Binds to Ck2-Cyclin E/A to inactivate

Question 16

What levels change in breast, colon, and prostate cancer?

Answer 16

Cyclin D is upregulated, p27 is downregulated

Question 17

What is mutated/deleted in bladder and pancreas cancer?

Answer 17

CKI p16

Question 18

How does Rb affect the cell cycle and cell proliferation?

Answer 18

Rb binds to E2F unless phosphorylated by Cdk4-D or Cdk6-D1/2/3.

When phosphorylated, E2F is free to to bind to S phase gene promoters and activate them allowing S phase progression

Question 19

What does E2F do?

Answer 19

Activates genes involved in DNA synthesis (S phase)