Stem cell Transplantation

Question 1

what is a of Haematopoietic Stem Cell Transplant

Answer 1

*hematopoietic stem cells of any donor/source are given with intention of repopulating/replacing the hematopoietic system in total or in part

Question 2

what are the types of stem cell transplants

Answer 2

• Allogenic
• Autologous

Question 3

Describe allogenic haemopoitic stem cell transplants

Answer 3

• stem cells from donor
• rejection/graft vs host defence
• takes longer for immune system to recover (opportunistic infections very common
• b

Question 4

Describe Autologous haemopoiteic stem cell transplants

Answer 4

• graft stencils from self (not donor)
• cells frozen in lab befoe conditioning therapy
• no rejection due to self cells
• for myeloma and lymohoma
• no graft vs malignancy effect
• does not treat the cancer

Question 5

are haeopoitetic stem cells transplants first line treatment

Answer 5

no

Question 6

what determines a haemopoitetic stemm cell match

Answer 6

matching at HLA loci
6 main: HLA loci, A,B,B DP,DQ,DR)

Question 7

Which conditions do you preform autologous transplants for

Answer 7

myeloma
mantle cell lymphoma
lymphomas

Question 8

Which conditions do you preform allogenic transplants for

Answer 8

• acute and chronic leukemia
• Aplastic Anaemia
• sickle cell
• thallasemia