Myledosplastic disorders and acute myloid leukemia

Question 1

what is acute myloid leukemia

Answer 1

• heterogeneous clonal malignancy
• characterized by immatuce myleoid cell proliferation (more blasts) and bone marrow failure
• mostly over 65s

Question 2

Whar is cytopenia

Answer 2

low blood count

Question 3

what is panctopenia

Answer 3

low haem, platelets, and neutrophls

Question 4

what would a peripheral blood film show in AML

Answer 4

• dysplasia
• hypogranular neutrophils

Question 5

aetiology for AML

Answer 5

• Previous expo to chemo
• genetic mutationsx

Question 6

what does histology of AML show

Answer 6

auer rods

Question 7

what are the investigations for AML

Answer 7

• FBC
• blood film
• haematinics
• bone marrow aspirite

Question 8

Presenting symptoms AML

Answer 8

• anemia
• neutropenia (infection)
• thrombocytompenia -(bleeding + bruising)

Question 9

Describe morphology of AML

Answer 9

• normal minimum 20% blasts
• can be lower than 10 for genetic

Question 10

Describe morphology of MDS

Answer 10

• 10% dysplasia in cells
• blasts from 0-19%

Question 11

Demographics AML

Answer 11

• Old age (80s)
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Question 12

Treatment of AML

Answer 12

• Chemo
• allogenic bone marrow transplant (cures)
• to treat the neutropenia -antibiotics
• anemia - transfusion
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Question 13

Give some differential diagnosies for AML

Answer 13

• ALL
• Severe sepsis -