Low grade lymphoma Flashcards
1
Q
what is a lymphoproliferative disease
A
neoplastic/clonal proliferation of lymphoid cells
2
Q
how do we broadly class lymphoma
A
- lymphoma split into non hodgking and hodgking
- non hodgking further split into aggressive and indolent
3
Q
why are B-cells and B-cell lymphoma
are more common than other types of lymphoma?
A
B cell dominance
4
Q
what are the characteristics of indolent lymohoma
A
- slow growing
- advanced at presentation
- incurable
5
Q
whats the median survival of indiolent lymphomas
A
9-12 yrs
6
Q
in indolent lymphoma patients what are the usual causes of death
A
- from lympoma itself
- can ‘upgrade’ to high grade lymphoma
-richters transformation from CLL
7
Q
Describe aetiologuy of lymphoma
A
- most cases is unknown
- primary imunodeficiency: wiscot-aldrich-syndrome
- secondary immunodeficiency: HIV
- infection: EBV, H.pylori
- autoimmune disorders
8
Q
how would you investigate a lymphoma
A
- lymph node biopsy (reed sternberg ceclls in hodgkings)
- CT: staging
- FBC in nonhodgkings for possuble anermia
9
Q
Treatment for indolent NHL
A
- possibly nothing if non symptomstic
- Radio:
- chemo
- immunotherapies: BiTE and CAR-T
