Stem cell therapy Flashcards
Pluripotent stem cells can give
rise to neural stem cells.
True or False?
True (can give rise to any kind of cell, all three germ layers)
ESCs and iPSCs are equivalent for
transplantations as part of stem cell
therapies.
True or False?
False, the tumor risk is too high
Umbilical cord blood
derived stem cells can be
used for clinical
applications directly
True or False?
False, secondary answer: It is possible but too small concentration and little blood in cord
Induced pluripotent stem cells pose no
concern of immune rejection.
True or False?
False, there is graft versus host disease risk (GVHD)
Guided differentiation of induced pluripotent stem
cells into blood cells in a lab setting can be used
for clinical applications.
True or False?
False, only blood cells are viable, nothing else works atm
What are stem cells?
They can self-renew
They can differentiate into
specialized mature cells
Originate from blastula
Totipotent stem cells?
Can give rise to an organism e.g. zygote
toti = whole
Pluripotent stem cell?
Can give rise to all three germ layers (mesoderm, endoderm and ectoderm)
Multipotent stem cell?
Adult stem cells e.g. a neural stem cell or a hematopoietic stem cell
Which cells are most valuable for research and clinical application?
Pluri and multipotent stem cells
Can SC therapy be used for Parkinsons disease?
Yes, hES cell-based dopamine nerve cell product
Can SC therapy be used for CVD disease?
Yes, iPSC-derived cardiomyocytes
(iPSC-CM) can be used to
remuscularize the damaged region of the
heart in patients that have suffered a
myocardial infarction
What are some of the safety limitations for SC therapy?
Teratomas
Insertional Mutagenesis
Genomic Integrity
Risk of Immunogenicity
Limitation: Are SC a scarce resource
Yes
Limitation: Are stem cells complicated to produce?
Yes, they Complicated manufacturing/ differentiation procedure
