PK/PD Flashcards
Determines what the drug does to the body..
Pharmacodynamics
What the body does to the drug… fate of the drug…
Pharmacokinetics
The relationship between concentration and response and response duration is covered under?
PD
With ex/in vivo and in vitro, animal models (limitations)
ADME
absorption
distribution
metabolism
excretion
A proportionality factor that relates the amount if drug in the body to the concentration of the drug measured (V=dose/conc)
Distribution - volume of distribution (V)
A constant determining the body’s ability to clear a specific volume completely of drug e.i. the volume of plasma cleared of drug per unit time (e.g. mL/h)
Elimination - clearance (CL)
… The time required for the concentration to fall to 50% of the initial value assuming a 1-compartments model and linear elimination
Half-life t1/2
The fraction of givenn dose that unchanged reaches the systemic circulation
Bioavailability (F)
The rate at which unchanged drug proceeds from site of adminstration to site of measurement within the body
absorption rate (ka)
Main ADME differenced between biologics and SOMS?
SOMs:
Route: orally| intestinal uptake | LogP/solubility dependent distribution iver enzymes P450 dosage daily-weekly | kidney/bile excretion
Biologics:
Route: IV, SC, IM| uptake in blood stream | FcRn binding, lymphatic system distribution | peptidase catabolism | dosage weekly-monthly | reentering of aa
What advantages dose biologics have against SOMs regarding drug clearance/elimination?
Abs can be recycled to the plasma with FcRn. The Ab should have a pH dependent dissociation from antigen in the endosome
What disadvantage does biologics have compared to SOMs
They are big > 1kDa (SOMs < 1 kDa)
Inherently unstable
The mode of action MoA is not fully understood by some biologics and therefore… is required for setting dose regime
MABEL
