Immunotoxicity Flashcards
What is immunotoxicity?
Immunotoxicity is an adverse or inappropriate change in the structure and function of the immune system after exposure to a foreign substance.
ADAs?
Antibody drug antibodies
What route of adminstration is best for multiple dose?
IV not SC because of more immune cells present in the skin to fight foreign species
What types of immunogenicities are there?
Immunosuppressive
Autoimmunity
Hypersensitivity (1-4)
Infusion reaction
Type I hypersensitivity is related to?
Anaphylaxis
Type II hypersensitivity is related to?
Trombocytopenia
Type III hypersensitivity is related to?
Serum sickness
Type IV hypersensitivity is related to?
Allergy, DRESS, SJS, TEN and AGEP
Infusion reactions can manifest as?
Anaplylaxis, anaphylactoid reactions, cytokine release syndrom
How can immunosuppression be induced?
IFN-a treatment → blocking hemtological bone marrow colony-forming units leading to myelosuppression
What is autoimmunity associated with?
drug-induced lupus DIL
How is Type I hypersensitivity mediated
IgE immediate reaction 2-30 min
How is Type II hypersensitivity mediated
IgG and IgM cytotoxic reactions 5-8h
How is Type III hypersensitivity mediated
(IgG and IgM) Immune complex-mediated reaction 2-8h
How is Type IV hypersensitivity mediated
(T) cell-mediated 24-72h