STDs Flashcards
etiology of chlamydia
- chlamydiaceae trachomatis
- obligate intracellular w/ gram negative like cell wall
MC infected w/ chlamydia
AA females 15-24 yo
different serotypes of chlamydia
- A, B, C: trachoma (eye)
- D-K: mucosal surfaces
- L1, L2, L3: lymphogranuloma venerum (LGV)
lymphogranuloma venerum (LGV)
- small, often asx genital skin lesion then regional lymphadenopathy in groin/pelvis
- Lesions heal with scarring, can have persistent sinus tracts
- Severe proctitis if aq. via anal sex
- Same dx testing as general
- Tx: Doxy 100 mg PO BID X 21 days or erythromycin 500 mg PO QID X 21 days
Transmission of chlamydia
- Mucosal contact: vag, oral, anal sex
- Highly contagious (partner infection rate >50%)
- Can pass sexual (genital) or vertical (perinatal)
- Perinatal: neonatal conjunctivitis or pneumonia
- Increases risk of acquiring HIV d/t mucosal inflammation
- Sig asymptomatic carriers
- Reinfection common
Chlamydia screening
yearly if sexually active and <25 yo
S/S of chlamydia in women
- Cervicitis: clear to thick yellow discharge and abnl vag bleeding
- Urethritis: dysuria-pyuria (but no wbc), abd pain, fever
(80% asymptomatic)
S/S of chlamydia in men
- > 50% asx
- Urethritis MC: clear, yellowish, white discharge. Dried secretions at urethral meatus
- Proctitis, dysuria, urinary freq or urgency
- Complications: epididymitis and reactive arthritis
PE of chlamydia
- Female: thick, mucopurulent discharge in cervical os
- Male: mucoid/watery urethral discharge
Labs for chlamydia
Nucleic acid amplification tests (NAATs) PCR DNA probe
- urine or bodily fluid
- MC used, very accurate
Culture/gram stain
- Culture swab from site of infection
- Tx empirically, can take 24-48 hrs for results
ELISA
- looks for antigens to pathogen
- less accurate than culture but second most specific
Tx of chlamydia
- Azithromycin: 1 g once (not for QT prolongation, meds for arrhythmia)
Special points to note about chlamydia
- Must report to health dept
- If exposed or you think positive, treat!
- Treat all sex partners if have had sexual contact during 60 days preceding onset of sx/dx
- Abstain from sex 7 days after last day of tx
- Check for gonorrhea – 40%F and 20%M co infected
- Retesting recommended 3 mos after therapy d/t high rates reinfection
- MSM screened annually for urethral or rectal infection
- MSM + HIV or risky behavior = 3 month screening
PID associated with chlamydia
- from ascending infection
- Chronic abd pain d/t adhesions of ovaries and fallopian tubes
- Inc chance of ectopic preg X7-10
- Untreated = fertility
- Fitz-Hugh-Curtis sx: (inflammation of liver capsule, RUQ pain, abnl LFTs)
- Reactive arthritis
Reiter syndrome / reactive arthritis d/t chlamydia
- 2 to immune-mediated response to chlamydia
- Sx: asymmetric polyarthritis, urethritis, conjunctivitis
- RF/HLA-B27 negative
- “can’t see, can’t pee, can’t climb a tree”
etiology of gonorrhea
- neisseria gonorrhoeae
- gram neg. diplococci
- incubation 1-14 days or 2-5 days
MC infected w/ gonorrhea
15-24 yo F
transmission of gonorrhea
- Mucosal contact during vaginal, oral, anal sex
- can affect any part of body/organs/mucous membranes
- Easy transmission: single encounter with infected partner = infection 50-70% of the time!
screening of gonorrhea
Annual if sexually active & <25 yo
S/S of gonorrhea in female
- most asx
- urethritis
- cervicitis
- thin, purulent**, mild odor discharge
S/S of gonorrhea in male
- most sx urethritis: burning on urination, purulent/mucopurulent discharge
- Acute epididymitis: unilateral testicle pain/swelling, prostatitis, cystitis
other sx associated w/ gonorrhea
- Rectal: often asx. Rectal pain, pruritis, tenesmus, rectal discharge. Bloody diarrhea. Rectal infection
- Oropharyngeal: often asx, can cause mild-severe dysphagia and discomfort
- Eye: most often unilateral if 2 to self-inoculation, purulent discharge, conjunctivitis, can = blindness
Labs for gonorrhea
same as chlamydia
tx of gonorrhea
Dual therapy:
- Rocephin 250 mg IM once + Azithromycin 1 gm PO once
- Alt: cefixime + azithromycin
- pain relief for epididymitis, PID, DGI
special points to note about gonorrhea
- Must report to health department
- If exposed or you think positive, treat!
- Screen if asx but partner known infection
- Untreated can lead to accessory gland infection (Bartholin, skene)
- PID
- Fitz-Hugh-Curtis sx (inflammation of liver capsule, RUQ pain, abnl LFTs)
- Test of cure not necessary with dual treatment, is recommended if used alt meds
Disseminated Gonorrhea Infection (DGI)
- d/t untreated gonorrhea that spreads to blood
- arthritis, tenosynovitis, dermatitis + any of the following:
• Fever
• Skin change: rash on torso, limb, palm, sole. Abscess formation
• Joint: polyarthralgia, purulent arthritis (knee MC)
• CNS: meningeal sx, decreased mental status
• Cardiac: murmur, tachy, endocarditis, embolic lesions
Tx of DGI
Ceftriaxone 1 g IM and Azithromycin 1 g PO daily X 7 days
Etiology of trichomonas
- T. vaginalis
- oval shaped, flagellated protozoa (swimming football)
- Incubation days to weeks
screening for trchomonas
Screen all positive pts for other STIs
Transmission of trichomonas
- F
- M
- Women: vagina, cervix, urethra, bladder, Bartholin and Skene glands
- Men: anterior urethra and prostate
S/S of trich in women
- 70% sx
- copious, frothy, watery, yellow-green vag discharge
- dysuria
- vag irritation
- Vulvar edema
- +/- abd pain
- Strawberry cervix**
Labs for trich
- Wet mount prep: visualize T. vaginalis on slide
- Culture
- NAAT
- DNA probe
Tx of trich
- Metronidzaole 2 g PO Once (avoid etoh)
Alternatives: - Metro 500 mg PO BID X 7 days
- Tinidazole 2 g PO once
Special points to note about trich
- Complications: PID
- Pregnancy: 30% more likely to deliver preterm or low birth weight infant. Avoid metronidazole in first trimester (teratogenic risk)
- Recommend retest sexually active women 3 months after treatment
- Up to 53% women with HIV also have t. vaginalis. Screen at initial HIV visit, cure rate better with Metro 500 mg BID x 7 days
etiology of syphilis
- Treponema pallidum
- spirochete bacterium (corkscrew-shaped)
- Must use dark field microscopy
transmission of syphilis
- Dz progresses in stages
- Congenital transmission = congenital syphilis
- MSM are majority of new cases, higher rates of abx resistance
- Enters body via abrasions on skin/mucous membranes during sexual contact OR transplacentally during pregnancy
- Disseminates via circulatory system (incl. lymph)
- CNS invasion may occur in any stage
primary syphilis infection
- Ulcer or chancre on penis or vagina
• Painless, indurated, clean base. Can have multiple lesions
• Highly infectious but heals spontaneously within 3-6 weeks - Most contagious stage (primary and secondary)
secondary syphilis infection
- Secondary lesions several weeks after primary chancre, may persist weeks to months
- Mucocutaneous
- Manifestations
• Skin rash – nickel/dime sized, generalized over body, palms/soles
• Lymphadenopathy 50-80%
• Malaise, alopecia
• Condylomata lata*** - Serologic tests usually highest titer
Tertiary (late) syphilis infection
- approx. 30% untreated progress within 1-20 years
- Rare bc of abx
- Mannifestations:
• Gummatous lesions***
• Cardiovascular syphilis
Latent syphilis infection
- Host suppresses infection, no lesions clinically apparent
- Only evidence is positive serologic test
- Occurs between 1 and 2 stage, between 2 relapses, after 2 stage
- Early latent < 1 year duration
- Late latent ≥ 1 year duration
Neurosyphilis infection
- Invasion of CNS
- Can occur at any stage, may occur decades after infection
- Can be asx
- Tabes dorsalis